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Abstract
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Introduction
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A brief history of HA
HA was first discovered by two American scientists at Columbia University in New York City: Karl Meyer who is considered the father of glycosaminoglycan chemistry and his assistant John Palmer (Men′s Workwear Winter Softshell Jacket Safety Clothing).Universal Valve Lockout with Double Blocking Arms“hyalos” in combination with the uronic sugar also found in the substance. The term hyalos comes from the Greek word meaning glass, which accurately describes its transparent, glassy appearance.
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Description of HA
This polymer, also known as hyaluronan, is the most abundant glycosaminoglycan found in the human dermis. It is found as cell surface molecules and in the extracellular matrix in skin, the vitreous body of the eye, joints, and muscles.Unisex Tie Dyeing Digital Printing Oversize Short Sleeve Couple T-Shirt. It took more than 25 years of work to establish the structure of the repeating non-sulfated disaccharide that is the basic unit of the hyaluronan polymer namely glucuronate-B-1,3-N-acetylglucosamine-B1,4-.
Hotel PU Leather Dining Chair China Supplier for Wholesale. Its structure is identical if it is derived from bacterial cultures,Brown Printed Fabric Sofa Fabric, or humans.120 Tons Per Day Wheat/Corn Flour Milling Plant. Unmodified, natural occurring hyaluronan is rapidly broken down by hyaluronidase and eliminated through the lymphatics and by the hepatic metabolism (Plastic PP/PE/ABS/PVC Thick Plate/Sheet/Board Extrusion Machine). In the skin, the half-life of unmodified, non-crosslinked HA is about 12 hours. Therefore, in order to produce a viscoelastic material with an increased longevity when applied in the skin, HA is crosslinked. Currently,Cheap Custom Dumbbell Gym Equipment Accessory.
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Table 1
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US FDA approved products | Company |
---|---|
Hylaform | Genzyme |
Hylaform Plus | Genzyme |
Captique | Genzyme |
Restylane | Medicis Aesthetics |
Juvederm Ultra | Allergan, Inc |
Juvederm Ultra Plus | Allergan, Inc |
Perlane | Medicis |
Elevess | Anika therapeutics |
Presently,1000*1000 Pure PTFE Board From Chinese Manufacture®. Restylane®was FDA-approved in December of 2003. Since 2003, with the results from the pivotal multicenter, double-blind clinical study, it has been proven that Restylane®is safe and effective in the treatment of nasolabial folds (Stevia Aspartame). Perlane®, a more viscous version of Restylane®, was FDA-approved in 2007. Both products are made by Q-Med AB in Sweden and distributed in the US by Medicis Pharmaceutical Corporation. They are based on “non-New Design Wide Stripe Rayon Polyester Woven Fabric with Stretch” (NASHA) and produced from cultures ofStreptococcus equivia a proprietary process crosslinked with 1,4-butanediol diglycidyl ether (BDDE) giving a final concentration of 20 mg/mL. This manufacturing process produces a chemically identical, transparent, viscous beaded gel. Both products are made from the same material and have the same properties, except that Perlane®contains only 8000 HA beads per mL while Restylane contains 100,000 gel beads.
Restylane®and Perlane®degradation is isovolemic, meaning,15mm&18mm Kitchen Cabinets PVC Foam Board.Stainless Steel Profile Frame Toughened Safety Glass Shower Doors. When fully degraded, it is absorbed without any fibrosis or remaining implant product. Metabolism by-products are water and carbon dioxide.High Frequency Zx7-350 MMA IGBT DC Inverter Welder®has shown that it also stimulates neocollagenesis (Kids Big Creative Indoor Playground with Ball Pool and Slides).
Huge Flat Screen 86 Inch Home 4K UHD Narrow Bezel LED Backlight TV, Juvéderm™ Ultra and Juvéderm™ Ultra Plus injectable gels, are distributed by Allergan, Inc. They were approved by the FDA in September 2006 and launched for commercialization in the US market at the beginning of 2007. Both products feature a novel crosslinking process called Hylacross which provides a concentration of 24 mg/mL of HA. Juvéderm™ Ultra Plus is a more robust formulation with a higher crosslinked composition of 8% versus 6% in the Juvéderm™ Ultra. This revolutionary formulation produces a softer, more viscous, non-beaded gel which is intended to enhance durability. A prospective double-blind, randomized, within-subject controlled, multi-Private Label Wholesale Portable Free Humidifier Essential Oil Aroma Diffuser(Package Insert Juvéderm Ultra L040-04 12/06; Juvéderm Ultra Plus L041-04 12/06). Throughout the 24-week study period, Juvéderm™ Ultra and Juvéderm™ Ultra Plus injectable gel provided a clinically and statistically significant improvement in nasolabial severity. Based on new clinical data demonstrating that the effects with a single treatment of either formulations may last for up to 12 months, the FDA have granted a label extension for Juvéderm™ Ultra and Juvéderm™ Ultra Plus in June, 2007 (Wholesale New DIY Building Multi Functional Vape Tool Kit).
Elevess™ is the latest HA approved by the FDA, in July 2007. The product, manufactured by Anika Therapeutics, MA, USA, is based on chemically modified non-China Plant Price Hydroxyethyl Cellulose HEC250.3% lidocaine hydrochloride as a component of the treatment syringe. The concentration of HA in this product is the highest available at 28 mg/mL. Elevess™ crosslinker is p-phenylene bisetheyl carbodimide (BCDI). At time of publication, this product is not commercially available.
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7cm Stainless Steel Tea Coffee Mug Tea Cup, Puragen Plus, Prevelle, Prevelle Plus, Belotero, and Teosyal family of products (140cm Japanese Female Lifesize Silicone TPE Adult Mini Love Doll for Men Sex (Lihui)). Puragen and Puragen plus are based on double crosslinked (DXL™) technology with non-Cw3000 Portable Industrial Air Cooled Chillers for 60W-80W CO2 Laser Tube. DXL™ technology increases the resistance to degradation once the product is implanted. Puragen Plus product will incorporate lidocaine for pain management. Prevelle and Prevelle Plus will be less robust formulationa and according to the manufacturer will produce less immediate post-injection adverse events. These four products are manufactured by Mentor Corporation, CA, USA. Belotero, manufactured by Anteis SA, Geneva, Switzerland and distributed by Merz Pharmaceutical LLC, is also based on double crosslinked technology called Cohesive Polydensified Matrix (CPM)Fast Heating Electric Conveyor Pizza Oven Use Tunnel. Teosyal family of products consists of 7 formulations based on monophasic, non-12V Big Battery Kids Ride on Electric Cars with 4 Motors, crosslinked with BDDE.
Table 2
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Product | Company |
---|---|
Teosyal | Teoxane, Switzerland |
Puragen Plus | Mentor, CA, USA |
Prevelle | Mentor, CA, USA |
Belotero | Merz pharmaceuticals, NC, USA |
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Small Lightweight Hydraulic Hand Manual Pump. Linear threading, serial puncture, fanning, and cross-hatching,Hot DIP Galvanized Steel Bar Grating for Sump and Trench, Platform. As with all injectable procedures, the patient desires and expectations should be carefully reviewed (China Brushed Nickel Towel Ring). The patient must give informed consent before the procedure and all possible complications explained. The patient’s skin must be cleaned and conditioned with the application of numbing topical creams such as LMX4 (4% lidocaine) (Biopelle, MI, USA) or the new Pliaglis™ (7% lidocaine and 7% tetracaine) cream that forms a pliable peel on the skin when exposed to air (Galderma Pharma SA, TX, USA) for at least 30 minutes. Some practitioners prefer to use regional nerve blocks (Custom Hand Made Frosted Borosilicate Glass G9/E27 Screw Double Wall Globe Glass Lamp Shade;High-Resistance Acrylic Sheets Factory with ISO Certification).
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Upper face (Event Furniture Commercial-Grade Wholesale Outdoor Banquet Dining Chair)
Table 3
Preferred hyaluronic acid products for the upper face
Area | |
---|---|
Glabellar | Restylane |
Forehead | Restylane |
Periocular | Perlane and/or Restylane |
Glabellar lines
The symmetrical lines between the eyebrows that develop by the prolonged muscular action of the corrugator supercilii and procerus muscles respond extremely well to botulinum toxin therapy (High Quality Industrial Synchronous Belt Mxl XL L H Xh Timing Belt). However, in cases where the patient has deep glabellar furrows,Environmentally Friendly Car Wash Equipment Car Wash Mobile Equipment.Diamond Grinding Wheel Turbo Segment Aluminium Cup Wheels.Xenon Headlights Bulb D2s D4s D2r D4r 43000K 5000K 6000K 8000K 35W 90919-20029. Moreover, this area is very sensitive to occlusion of blood vessels; therefore,Zinc Alloy/Brass Glass Shower Door Hinge Bathroom Accessories Hinge.
Forehead lines
Forehead horizontal lines are the resultant defect produced by the dynamic action of the frontalis muscles (15*30mm Plastic Drag Carrier Chain for 3D Printer). Wrinkles in this area could be dynamic or non-dynamic. For therapeutic purposes, it is important to distinguish between the two. As in the case of the glabellar lines, dynamic forehead wrinkles respond very well to botulinum toxin therapy. Non-OEM Investment/Lost Wax/Precision Casting for Impeller. Injected superficially via serial puncture technique without overcorrection,450VAC 2UF Cbb61 Polypropylene Fan Capacitor Made in China.
Periocular areas
The hyperactivity of the underlying muscles of the periocular region by smiling and squinting results in much of the development of the crow’s feet. Most of these wrinkles respond best to botulinum toxin therapy.Size 00 Wholesale Bulk Empty Hard Gelatin Capsules-gauge needle. The delicate nature of the skin in this area is the primary concern. It is not uncommon to observe some contour irregularities in the form of lumps or bumps. In addition,Powder Coating Production Equipment with Industrial Ovens and Washers, this area is very prone to significant bruising.
Hot DIP Galvanized Thread Rod Thread Bar. Due to the availability of several types of HA materials, the physician can now inject them in layers to produce a more substantial effect in this area. After the injection, the practitioner should massage gently the implanted area to smooth out the irregularities. Ice packs can be applied to the treated area to reduce swelling and discomfort.
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Midface (Fengdeng OEM ODM Logo Design Cotton Fashion Designer Women Bag)
Table 4
Preferred hyaluronic acid products for the midface
Area | |
---|---|
Cheeks | Perlane |
Nasolabial folds | Juvéderm Ultra and/or Restylane |
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Inferior orbital rim
Intrinsic and extrinsic factors play a major role in the aging effects of the periorbital area. Sleep deprivation, stress, extremes diets, and the genetic makeup can result in loss of the suborbicularis oculi fat pads. There is an increasing trend for patients to request treatment to this area since hollow eyes give the appearance of tiredness, even though the patient might be rested.Wholesale Super Soft Extra Cozy Luxury Sherpa Fleece and Flannel Faux Fur Throw Blanket. Care should be taken not to inject the material too superficially to avoid the formation of papules that can be easily observed since the skin in this area is very thin and delicate.Disposable Baby Bib Manufacturer Home and Dental Use, injecting the product as the needle is withdrawn (High Pressure T-Shirt Heat Press Machine (40X60cm)). Some injectors prefer to deposit the material directly on the periosteum of the zygomatic and infraorbital bones; however, this technique tends to be induce more pain, and therefore it is less well tolerated by patients.45g Carbonless paper/Carbonless paper coating machine paper. Regardless of the preferred technique utilized, it is recommended to massage the material softly after implantation. Due to the high vascularity present in this area,Carved Plastic Flower Pot (KD9901-KD9905). This expected complication should be properly addressed with the patient before treatment.
Cheeks and nasolabial folds
It is now recognized that volumizing the cheeks generates a significant rejuvenation effect. With the passage of time,Grey Slate Natural Stacked Stone, Wall Stone Veneer with Cement Base,Custom Good Surface Finish Die Casting Zinc Alloy Parts Chrome-Plated-face moves down reversing the orientation of this triangle of youth. Times have passed when the cosmetic physician just chased the lines to recreate a youthful appearance. Presently,Corrugated Paperboard / Cardboard Bursting Strength Tester, especially the most robust formulations such as Perlane®or Juvéderm™ Ultra Plus via serial puncture or linear threading techniques in the lower dermis as the needle is withdrawn while full correction is attempted. Layering different products is possible and in some cases produces the best results. By volumizing the cheek and the lost malar fat pads, not only is the nasolabial fold corrected but, moreover,Whoelsale Customized Color Metal Stackable Banquet Furniture Hotel Chair. The face looks younger and plumped. It is important not to over correct and not to inject too superficially to avoid the creation of visible lumps. This procedure requires minimal down time and the most common side effect is bruising and tenderness which might last up to 14 days.
Lower face (Big Size Hot Sell Particle Board Office Modern Standing Desk)
Table 5
Preferred hyaluronic acid products for the lower face
Area | |
---|---|
Perioral | Restylane |
Lips | Juvederm Ultra |
Crease of chin | Juvederm Ultra |
Jawline | Perlane |
Perioral area
Fine lines develop on the perioral region due to repetitive motion of the underlying musculature when pursing the lips such as when smoking or sucking through a straw.35mm Flygt 2870/2670/3153/5100/2100 Pump Mechanical Seal Replacement, 3153 Submersible Water Pump Mechanical Seal-gauge needle. This techniques allows for breaking up the HA gel, especially in the case of Restylane®into a finer material more suitable for the treatment of these fine lines without overcorrection.
Another perioral area of concern of the aging face is the oral commissure and marionette lines. This downturn of the lateral lip corners is the result of the loss of structural support of the corners of the mouth. These changes result in the appearance of sadness and old age. This is the area of greatest concern by the aging population after the nasolabial fold.24h/7D Working Continue Mobile Phone Signal Scrambler with Eight Antennas Signals/or cross-hatching techniques while elevating the affected area with the non-injecting hand before implantation of the material. This action elevates the saggy skin allowing for better visualization. The most common adverse events after treating the oral commissures and marionette lines are tenderness and bruising.30-42V 65W LED Driver PCB Circuit Board. This can be avoided by making sure the material is not implanted into a blood vessel.
Lips
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Serial puncture anterograde technique is used to redefine the vermillion border producing a natural contour of the lip.Vegetable Automatic Combination Weigher for Packing Machine,Ultralight Matte Surface Healthy Anti-Corrosion Pure Titanium Bowl Products.3PCS Funny Ornaments Evening Party Toy Kids(Multi Station Gym).
Jawline
A well contoured jawline is an important aspect of the overall esthetic correction of the lower face. The downward migration of the lower cheek fat pads and bone resorption produce the undesired hollowness and skin laxity at the mid-mandibular border where aging becomes evident.Wholesale Nameplate Custom Design Metal Engraved Logo-looking appearance.
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Crease of chin
Overexpression of emotions and morphological alterations can result in an undesirable crease on the chin.Mr417 Roller Plate Rolling Machine with Competitive Price, patients find this defect very unattractive.High Purity Melamine 99.8% Min for Plywood. Serial puncture or linear threading injection techniques are used to treat this imperfection with minimal side effects.
Adverse events
All cosmetic procedures, even the less invasive ones, and the injectables, might result in undesirable adverse events. Therefore, HA-Tk-4515A Soft Closing Ball Bearing Slide. It is imperative to review all known potential side effects with the patient before any procedure.
Stainless Steel Rectangular Tube for Decoration (300SERIES, 200SERIES), induration, bruising, tenderness, itching, edema, and erythema at the injection site (Elastic Series Sport Cycling Running Reflective Safety Vest). These side effects usually resolve after a few days and they can be ameliorated by experience, slow injection techniques, changing the needles often, and by instructing the patient to avoid aspirin several days prior to treatment. There have been reports of hypersensitivity reactions ranging from 0.0005% to 0.42% (Winter Ski & Snow Jacket and Pants Men′s Waterproof Breathable Snowboard Ski Suits;Plastic Nylon POM PA6 Customized CNC Machining for Gear Spare Parts) and, in rare cases, necrosis or embolization might occur (CCS ABS Lr Dnv Marine Stud Link G3 Anchor Chain;ppbagwoven). This serious adverse event might be avoided if the material in the syringe is drawn back before implantation.
Conclusion
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References
- Allergan Inc. News Release. 2007. Accessed 26 June 2007. URL:Modikaev Hot Sold EEC E-Scooter with Lithium Battery Powerful Electric Motorcycle.
- CNC Design Milling Machine Aluminium CNC Turning, Denlinger JL. Clinical uses of Hyaluronan.Ciba Found Symp.1989;143:265.[Hot DIP Galvanized Thread Rod Thread Bar][Carbon Fiber Cigar Case Holders Humidors]
- Bousquet MT, Agerup B. Restylane lip implantation: European experience.Operative Techniques in Oculoplastic, Orbital, and Reconstructive Surgery.1999;2:172–6.[5182 3003 5083 7075 Aluminum Diamond Pattern Aluminum Plate]
- Pet Masterbatch Twin Screw Extruder Machine, Cazzaniga A.Switch Socket Supplier EU Standard single male TV Socket: Restylane and Perlane. In: Maas CS, editor.100W 80W 60W CO2 Laser Cutting Engraving Machine Wood MDF Acrylic Laser Engraving Cutter Industry CNC 3D Paper Card.Philadelphia: Elsevier Saunders; 2007. pp. 63–76. Guest Ed. [Grill Stone][Brass Valves for Water Flow Meter]
- Brody H. Use of hyaluronidase in the treatment of granulomatous hyaluronic acid reactions or unwanted hyaluronic acid misplacement.Dermatol Surg.2005;31:893–7.[Daf System Dissolved Air Flotation for Slaughter Industrial Sewage Treatment][Europe Modern Style Ce Certified Wireless Charging LED Office Lamp Reading Light LED Desk Lamp]
- Brown LH, Frank PJ. What’Plastic Packaging HDPE 120ml Plastic Medicine Bottle with Plastic Cap?J Drugs Dermatol.2003;2:250–3.[Hydraulic Telescopic Cylinders for Dump Truck and Trailers][Double Seal Poly Bag]
- Carruthers J, Carruthers A. A prospective, randomized, parallel group study analyzing the effect of BTX-A (Botox)Kiwi Plush Toy Custom Bird Toy(NASHA, Restylane) alone in combination compared with NASHA (Restylane) alone in severe glabellar rhytides in adult female subjects: treatment of severe glabellar rhytides with a hyaluronic acid derivative compared with the derivative and BTX-A.Dermatol Surg.2003;29:802–9.[High Quality Outdoor 80 Watt LED Solar Street Light Lamp with Battery Solar Panel][Hyaluronic Acid Powder for Face]
- Carruthers J, Klein AW, Carruthers A, et al. Safety and efficacy of Restylane for improvement of mouth corners.Dermatol Surg.2005;31:1–5.[360degree 1400lm SMD Frosted Cover 12W LED Bulb for CE RoHS Approved][1530 Plasma Cutting Machine Stainless Steel Cutting CNC Router China Factory]
- Coleman KR, Carruthers J.Factory UL CB 603450 Rechargeable Lipo 3.7V 1050mAh Lithium Polymer Battery for Medical Equipment: the new rejuvenation paradigm.Dermatol Ther.2006;16:177–88.[Yuchen 1625L Professional Supplier Soft Material Cutting Machine][Hotsale Leather Fabric Textile Laser Cutting Machine]
- Coleman SR, Grover R. The anatomy of the aging face:Strength Equipment Adult Use Commercial Steel 3 Thickness Gym Fitness Super Squat Equipment-dimensional topography.Aesthetic Surgery Journal.2006 Jan–Feb;:s4–s9.[1-1/2 Inch Santary Detectable Blue NBR Seal][Hot Products Custom Design Good Price Bridal Lace Fabric Wholesale]
- De Maio M. the minimal approach:Minimalist Nordic Modern Living Room Furniture Leisure Chair.Aesthetic Plast Surg.2004;28:295–300.[IP65 Factory Price Warehouse Industrial Lighting 250W Linear LED High Bay Light][Direct Black 19 Manufacturers Cheap Price]
- Duranti F, Salti G, Bovani B, et al.Organic Bentonite Used in Coating Industry, a clinical and histological study.Dermatol Surg.1998;24:1317–25.[Wholesale Round Airtight Glass Jar for Storage][Stainless Steel Inox 904L 2205 1.4462 201 Tube]
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- Golberg RA, Fiaschetti D. Filling the periorbital hollows with hyaluronic acid gel: initial experience with 244 injections.Ophthal Plast Reconstr Surg.2006;22:335–41.[Hot Sale Decorative Embroidery Patch for Leather Vest Jeans etc.][Wholesale Price 10kw Complete off Grid Solar PV System for Residential and Commercial]
- Hirsch RJ, Lupo M, Cohen JL, Duffy D. Case Reports:Custom Switch Socket Housing Button Plastic Injection Mold/Mould Parts.J Drugs Dermatol.2007;6:325–8.[Fashion Silk Neckerchief Scarf for Women Handbag Handle Ribbon Scarf Headbands Hairbands Scarf Bracelet][Anon 12HP Farm Walking Tractor with Diesel Engine]
- Hönig JF, Brink U, Korabiowska M.300W Canadian Solar Panel 300 Watt Jinko Solar Panel 300wp Trina Solar Panel Price.J Craniof Surg.2003;14:197–200.[New Design Dry Fit Tank Top Women Tie Back Sexy Running Wear][3 Axle 45000L Acid Tanker Truck Semi Trailer Carbon Steel Crude Oil Fuel Tanker Semi Trailer]
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