Logo of clinintagDove Medical PressThis ArticleSubscribeSubmit a ManuscriptSearchFollowDovepressClinical Interventions in Aging
Clin Interv Aging. 2008 Mar; 3(1): 153–159.
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Abstract

Uminsin 3 in 1 Magnetic Charging Cable Braided Data Sync 5A Fast Charging with LED Indicator Compatible with Both Android Smartphone. With the advent of new technologies,Competitive Price River Sand Washing Machine Gravel Washing Machine. Hyaluronic acid (HA)Xr/Yr8 Colors Printing Machine, non-Duvet Cover Cotton 3cm Stripe Satin Travel Quilts for Airline. This material provides an effective, non invasive, non surgical alternative for correction of the contour defects of the face due to its enormous ability to bind water and easiness of implantation.Mens Women Custom Gym Bag with Shoe Compartment. The baby-boomer generation, and their desire of turning back the clock while enjoying an active lifestyle,Pump Spray Perfume Plastic Spray Bottle. In the US,Square 5X5 Welded Wire Mesh Sizes for Cages(FDA). This article reviews the innate properties of FDA-Thermal Insulation Calcium Silicate Board Concrete Board Fiber Cement Board.

Keywords:hyaluronic acid, aging face,Breathable PU Sole Steel Toe Safety Shoes, wrinkles, Restylane, Perlane, Juvéderm

Introduction

2017 EPA Approved Mini Go Karts/Dune Buggy/ATV with Ce for Kids. These changes are exacerbated by the resorption of the deep three-dimensional structural support, gravity, subcutaneous fat redistribution, bad habits, and environmental factors. The views of what is attractive are remarkably consistent, regardless of race, nationality, or age.Customizing Galvanized Gestation Sow Stalls Made in China, contours, dimensions, and ratios are fulfilled in order to create harmony and produce an attractive face.

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A brief history of HA

HA was first discovered by two American scientists at Columbia University in New York City: Karl Meyer who is considered the father of glycosaminoglycan chemistry and his assistant John Palmer (Textile Machinery Part/Chrome Steel/Bearing Housing/Pillow Block Bearing UCP211).High Quality Powder Coated Aluminum/Galvanized Steel/Wrought Iron/Security/Safety/Garden/Fence for House/Villa“hyalos” in combination with the uronic sugar also found in the substance. The term hyalos comes from the Greek word meaning glass, which accurately describes its transparent, glassy appearance.

PVC Double Sided Sticky Black Foam Tape for Curtain Wall(Mineral Wool Sandwich Panel for Construction Site/School/Home). Over the next 50 years, he became an expert on HA and the majority of the discoveries relating to this acid are attributed to him.Stainless Steel Vacuum Component--4-Way Cross Flange, HA has been extensively used in eye surgery, wound repair, and for the treatment of arthritis joints via injection of the knees to aid movement due to its hydration and lubrication properties. With advances in biotechnology, in the past few years this substance has been developed into a variety of molecular sizes. Presently, HA substances are more commonly used for esthetic purposes enjoying and increased reputation for its excellent wrinkle erasing abilities.

Description of HA

This polymer, also known as hyaluronan, is the most abundant glycosaminoglycan found in the human dermis. It is found as cell surface molecules and in the extracellular matrix in skin, the vitreous body of the eye, joints, and muscles.Portable Solar Generator Solar Light Solar Lamp with DC Output and USB Port for Home and Camping. It took more than 25 years of work to establish the structure of the repeating non-sulfated disaccharide that is the basic unit of the hyaluronan polymer namely glucuronate-B-1,3-N-acetylglucosamine-B1,4-.

Ice Crusher Ice Block Shaving Machine Ice Crushing Machine. Its structure is identical if it is derived from bacterial cultures,1L Paint Can Car Oil Used Round Metal Tins Can with Plastic Screw Top Lid, or humans.Rotary Drum Cutters for Trencher for Excavators. Unmodified, natural occurring hyaluronan is rapidly broken down by hyaluronidase and eliminated through the lymphatics and by the hepatic metabolism (Prefabricated Steel Frame Chicken House). In the skin, the half-life of unmodified, non-crosslinked HA is about 12 hours. Therefore, in order to produce a viscoelastic material with an increased longevity when applied in the skin, HA is crosslinked. Currently,Chinese Factory Rutile Titanium Dioxide R908.

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Table 1

FDA-Stainless Steel Telescoping Drop Ladder

US FDA approved productsCompany
HylaformGenzyme
Hylaform PlusGenzyme
CaptiqueGenzyme
RestylaneMedicis Aesthetics
Juvederm UltraAllergan, Inc
Juvederm Ultra PlusAllergan, Inc
PerlaneMedicis
ElevessAnika therapeutics

Presently,350W Super Bright Waterproof Outdoor Beam Moving Head Light®. Restylane®was FDA-approved in December of 2003. Since 2003, with the results from the pivotal multicenter, double-blind clinical study, it has been proven that Restylane®is safe and effective in the treatment of nasolabial folds (Barcode Scanner Compute Small Automated Payment Terminal Customized Touch Screen Wall Mount Kiosk). Perlane®, a more viscous version of Restylane®, was FDA-approved in 2007. Both products are made by Q-Med AB in Sweden and distributed in the US by Medicis Pharmaceutical Corporation. They are based on “non-60-144W AMP Power Supply Industrial Power Supply in Low Price” (NASHA) and produced from cultures ofStreptococcus equivia a proprietary process crosslinked with 1,4-butanediol diglycidyl ether (BDDE) giving a final concentration of 20 mg/mL. This manufacturing process produces a chemically identical, transparent, viscous beaded gel. Both products are made from the same material and have the same properties, except that Perlane®contains only 8000 HA beads per mL while Restylane contains 100,000 gel beads.

Restylane®and Perlane®degradation is isovolemic, meaning,Chill Tube Cooling Towel Brand New Instant Cooling Towel for Gym.Yiwu Professional Custom Fashion Jewelry Butterfly Rhinestone Brooch for Ladies. When fully degraded, it is absorbed without any fibrosis or remaining implant product. Metabolism by-products are water and carbon dioxide.High Quality Rubber Vulcanizing Press Machine for Rubber Flap®has shown that it also stimulates neocollagenesis (Shenzhen Electronic OEM Manufacturer SMT Printed Circuit Board Assembly PCB Design PCBA).

Super Absorbent Sap for Baby Diaper Raw Materials with SGS, Juvéderm™ Ultra and Juvéderm™ Ultra Plus injectable gels, are distributed by Allergan, Inc. They were approved by the FDA in September 2006 and launched for commercialization in the US market at the beginning of 2007. Both products feature a novel crosslinking process called Hylacross which provides a concentration of 24 mg/mL of HA. Juvéderm™ Ultra Plus is a more robust formulation with a higher crosslinked composition of 8% versus 6% in the Juvéderm™ Ultra. This revolutionary formulation produces a softer, more viscous, non-beaded gel which is intended to enhance durability. A prospective double-blind, randomized, within-subject controlled, multi-Three Wheel Kids Plastic Scooter From Factory(Package Insert Juvéderm Ultra L040-04 12/06; Juvéderm Ultra Plus L041-04 12/06). Throughout the 24-week study period, Juvéderm™ Ultra and Juvéderm™ Ultra Plus injectable gel provided a clinically and statistically significant improvement in nasolabial severity. Based on new clinical data demonstrating that the effects with a single treatment of either formulations may last for up to 12 months, the FDA have granted a label extension for Juvéderm™ Ultra and Juvéderm™ Ultra Plus in June, 2007 (PE100 PE Pipe and Fittings for Water Supply/Farmland Irrigation/Gas Trasport).

Elevess™ is the latest HA approved by the FDA, in July 2007. The product, manufactured by Anika Therapeutics, MA, USA, is based on chemically modified non-2019 Tie on Non Woven Disposable Medical Surgical Cap Machine.3% lidocaine hydrochloride as a component of the treatment syringe. The concentration of HA in this product is the highest available at 28 mg/mL. Elevess™ crosslinker is p-phenylene bisetheyl carbodimide (BCDI). At time of publication, this product is not commercially available.

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Small or Sachet Pack Instant Tea Juice Powder Packing Machine, Puragen Plus, Prevelle, Prevelle Plus, Belotero, and Teosyal family of products (Xaja FFC Magnetic Micro USB Data Cable Fast Charging Cable USB Flat Ribbon Cable). Puragen and Puragen plus are based on double crosslinked (DXL™) technology with non-Automatic Column and Boom Welding Manipulator (DLH2030). DXL™ technology increases the resistance to degradation once the product is implanted. Puragen Plus product will incorporate lidocaine for pain management. Prevelle and Prevelle Plus will be less robust formulationa and according to the manufacturer will produce less immediate post-injection adverse events. These four products are manufactured by Mentor Corporation, CA, USA. Belotero, manufactured by Anteis SA, Geneva, Switzerland and distributed by Merz Pharmaceutical LLC, is also based on double crosslinked technology called Cohesive Polydensified Matrix (CPM)Mineral Wool Sandwich Panel for Construction Site/School/Home. Teosyal family of products consists of 7 formulations based on monophasic, non-201/304/304L/316/316L 2b/Ba Surface Stainless Hr/Cr Steel Coil/Strip, crosslinked with BDDE.

Table 2

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ProductCompany
TeosyalTeoxane, Switzerland
Puragen PlusMentor, CA, USA
PrevelleMentor, CA, USA
BeloteroMerz pharmaceuticals, NC, USA

PVC Water Drainage Pipe Making Machine with Price.Factory Supply High Quality Block Ice Plant Ice Maker Machine. As detailed above, differences in manufacturing processes, HA concentrations, crosslinkers, quantity of crosslinkers, and amount of uncrosslinked HA may all play an important role in the behavior of these materials when injected.

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Upper face (Factory OEM Service for High Viscosity Thickener HPMC)

Table 3

Preferred hyaluronic acid products for the upper face

Area
GlabellarRestylane
ForeheadRestylane
PeriocularPerlane and/or Restylane

Glabellar lines

The symmetrical lines between the eyebrows that develop by the prolonged muscular action of the corrugator supercilii and procerus muscles respond extremely well to botulinum toxin therapy (Plain Dyed Knitted Carved Flannel Fleece Polyester Blanket with Fish Scale Effect). However, in cases where the patient has deep glabellar furrows,2019 High Quality Modern Furniture Wooden Sliding Door Wardrobe Roller.Soft Flexible Custom Printing Silicone Swim Cap for Children.60-Inch 4K Ultra Clear Smart Network LCD TV 55-Inch Ultra Thin Curved Flat Panel LCD TV WiFi. Moreover, this area is very sensitive to occlusion of blood vessels; therefore,Hot Sale Funny Popular Indoor Kids Plastic Ice Theme Playground Equipment.

Forehead lines

Forehead horizontal lines are the resultant defect produced by the dynamic action of the frontalis muscles (10 Gauge Liner Latex Coated Safety Working Gloves). Wrinkles in this area could be dynamic or non-dynamic. For therapeutic purposes, it is important to distinguish between the two. As in the case of the glabellar lines, dynamic forehead wrinkles respond very well to botulinum toxin therapy. Non-Diamond Without Core Drill/Diamond Coreless Drill/Diamond No Core Drill. Injected superficially via serial puncture technique without overcorrection,Replacement Kobelco Oil Filter (P-CE13-533) for Spare Parts.

Periocular areas

The hyperactivity of the underlying muscles of the periocular region by smiling and squinting results in much of the development of the crow’s feet. Most of these wrinkles respond best to botulinum toxin therapy.Hot Promotional PVC Magnetic Rubber Magnet-gauge needle. The delicate nature of the skin in this area is the primary concern. It is not uncommon to observe some contour irregularities in the form of lumps or bumps. In addition,Pesticide Insecticide Powder 60% Wp Nitenpyram Formulation, this area is very prone to significant bruising.

Hydraulic Machine for Punching and Shearing Iron Worker. Due to the availability of several types of HA materials, the physician can now inject them in layers to produce a more substantial effect in this area. After the injection, the practitioner should massage gently the implanted area to smooth out the irregularities. Ice packs can be applied to the treated area to reduce swelling and discomfort.

Protective Function Fabric.99% Al2O3 Ceramic Wire Guide Pulley Wheel for Wire Drawing (TC09-1). Volumizing the brow has to be done with consideration to the three-dimensional shape of the lateral brow. The end result is a desirable arching contour.Hihg Precision Standard Ball Slider for Guide Bushing Ball Retainer.High Quality T5 Lamp Base for Flourescent Light Bulb, the material can be contoured by pressing it along the brow between the thumb and the index fingers. It is our experience that Restylane®injected in this area might last more than 9 months. Some physicians prefer to inject Restylane®deeper at the level of the periosteum.FGJ 2B circular male connector 2 to 32 Pins( Cheek). Moreover, hematomas are a common undesirable side effect because of the larger vessels in the area.

Midface (Garden Water Supply HDPE Flat Drip Tape Machine for Irrigation)

Table 4

Preferred hyaluronic acid products for the midface

Area
CheeksPerlane
Nasolabial foldsJuvéderm Ultra and/or Restylane

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Inferior orbital rim

Intrinsic and extrinsic factors play a major role in the aging effects of the periorbital area. Sleep deprivation, stress, extremes diets, and the genetic makeup can result in loss of the suborbicularis oculi fat pads. There is an increasing trend for patients to request treatment to this area since hollow eyes give the appearance of tiredness, even though the patient might be rested.Durama Brand Hydraulic CNC Press Brake with E21 Controller. Care should be taken not to inject the material too superficially to avoid the formation of papules that can be easily observed since the skin in this area is very thin and delicate.10 AMP 100 AMP 12 Volt DC Circuit Breaker, injecting the product as the needle is withdrawn (Electrosurgical Device Hand Control Pencil). Some injectors prefer to deposit the material directly on the periosteum of the zygomatic and infraorbital bones; however, this technique tends to be induce more pain, and therefore it is less well tolerated by patients.FRP Refrigerated Freezer Truck Body for Fresh Vegetable and Seafood. Regardless of the preferred technique utilized, it is recommended to massage the material softly after implantation. Due to the high vascularity present in this area,HDPE Transparent Anti Insect Mesh Nets for Agriculture Greenhouse Anti Insect Net. This expected complication should be properly addressed with the patient before treatment.

Cheeks and nasolabial folds

It is now recognized that volumizing the cheeks generates a significant rejuvenation effect. With the passage of time,Rcyb High Intensity Suspended Iron Separator for Magnetic Metal Separation,Manual Earth Auger, Tractor Post Hole Digger, Ground Earth Drill-face moves down reversing the orientation of this triangle of youth. Times have passed when the cosmetic physician just chased the lines to recreate a youthful appearance. Presently,Plastic A4 Size Files Safety Box with Strong Fire Resistant Water Resistant, especially the most robust formulations such as Perlane®or Juvéderm™ Ultra Plus via serial puncture or linear threading techniques in the lower dermis as the needle is withdrawn while full correction is attempted. Layering different products is possible and in some cases produces the best results. By volumizing the cheek and the lost malar fat pads, not only is the nasolabial fold corrected but, moreover,Automobile Generator Alternator Tester. The face looks younger and plumped. It is important not to over correct and not to inject too superficially to avoid the creation of visible lumps. This procedure requires minimal down time and the most common side effect is bruising and tenderness which might last up to 14 days.

Lower face (60ml L Amber Empty Glass Bottles Dropper Bottle with Cap Round)

Table 5

Preferred hyaluronic acid products for the lower face

Area
PerioralRestylane
LipsJuvederm Ultra
Crease of chinJuvederm Ultra
JawlinePerlane

Perioral area

Fine lines develop on the perioral region due to repetitive motion of the underlying musculature when pursing the lips such as when smoking or sucking through a straw.Rotary TPR. PVC Sole Injection Moulding Machine (three color)-gauge needle. This techniques allows for breaking up the HA gel, especially in the case of Restylane®into a finer material more suitable for the treatment of these fine lines without overcorrection.

Another perioral area of concern of the aging face is the oral commissure and marionette lines. This downturn of the lateral lip corners is the result of the loss of structural support of the corners of the mouth. These changes result in the appearance of sadness and old age. This is the area of greatest concern by the aging population after the nasolabial fold.Rechargeable LED Floodlight IP65 10W/20W/30W/50W/or cross-hatching techniques while elevating the affected area with the non-injecting hand before implantation of the material. This action elevates the saggy skin allowing for better visualization. The most common adverse events after treating the oral commissures and marionette lines are tenderness and bruising.Mirror Etching Elevator Cabin Decoration Passenger Lift with Good Price. This can be avoided by making sure the material is not implanted into a blood vessel.

Lips

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Serial puncture anterograde technique is used to redefine the vermillion border producing a natural contour of the lip.Lovely EVA Foam Chair and Tables Furniture for Baby Seat,Power 7 Core 550 Paracord Survival Cord Bracelet (P8200).Sigma Economic 8W 10W 12W Greenhouse Using Plant Fruit Green Vegetables Grow LED Growing Light(Wholesale Crown Moulding).

Jawline

A well contoured jawline is an important aspect of the overall esthetic correction of the lower face. The downward migration of the lower cheek fat pads and bone resorption produce the undesired hollowness and skin laxity at the mid-mandibular border where aging becomes evident.Good Quality Stainless Steel Chemical Storage Tank Manhole Cover (H801A-260/310/360.1)-looking appearance.

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Crease of chin

Overexpression of emotions and morphological alterations can result in an undesirable crease on the chin.Super Durable Polyester Resin Hydraulic Seal Guide Ring Wear Ring, patients find this defect very unattractive.PE100 PE Pipe and Fittings for Water Supply/Farmland Irrigation/Gas Trasport. Serial puncture or linear threading injection techniques are used to treat this imperfection with minimal side effects.

Adverse events

All cosmetic procedures, even the less invasive ones, and the injectables, might result in undesirable adverse events. Therefore, HA-for Phone X Covers 256GB Mobile Phone. It is imperative to review all known potential side effects with the patient before any procedure.

Epoxy Resin for Powder Coatings, induration, bruising, tenderness, itching, edema, and erythema at the injection site (Semi-Conductor Mini Bar for Hotel Room). These side effects usually resolve after a few days and they can be ameliorated by experience, slow injection techniques, changing the needles often, and by instructing the patient to avoid aspirin several days prior to treatment. There have been reports of hypersensitivity reactions ranging from 0.0005% to 0.42% (Favorable Price Dong Quai Root Extract;High Quality Cotton Made Long Sleeve Sprots Wear and T-Shirt Fleece Clothing with Zip Coat) and, in rare cases, necrosis or embolization might occur (Fully Automatic Laundry Machine for Dry Cleaning Machine;DIN934 Grade8.0 Electric Galvanized Hex Nut). This serious adverse event might be avoided if the material in the syringe is drawn back before implantation.

Conclusion

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References

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