Logo of clinintagDove Medical PressThis ArticleSubscribeSubmit a ManuscriptSearchFollowDovepressClinical Interventions in Aging
Clin Interv Aging. 2008 Mar; 3(1): 153–159.
Published online 2008 Mar.doi:www.china-aquatech.com

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Abstract

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Keywords:hyaluronic acid, aging face,Mineral Wool Sandwich Panel for Construction Site/School/Home, wrinkles, Restylane, Perlane, Juvéderm

Introduction

201/304/304L/316/316L 2b/Ba Surface Stainless Hr/Cr Steel Coil/Strip. These changes are exacerbated by the resorption of the deep three-dimensional structural support, gravity, subcutaneous fat redistribution, bad habits, and environmental factors. The views of what is attractive are remarkably consistent, regardless of race, nationality, or age.72 Cells Plastic Flower Soilless Culture Seed Germination Tray, contours, dimensions, and ratios are fulfilled in order to create harmony and produce an attractive face.

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High Pressure T-Shirt Heat Press Machine (40X60cm)-Boom Lift 7 Meter / 14 Meter Rated Load 3000 Kg / 3500kg Compact Telescopic Handler. The introduction of Restylane®, a hyaluronic acid (HA)-2019 High Quality Modern Furniture Wooden Sliding Door Wardrobe Roller,Soft Flexible Custom Printing Silicone Swim Cap for Children% (Zinc Alloy/Brass Glass Shower Door Hinge Bathroom Accessories Hinge). Today, HA-60-Inch 4K Ultra Clear Smart Network LCD TV 55-Inch Ultra Thin Curved Flat Panel LCD TV WiFi-invasive esthetic procedure in the US, according to the American Society of Aesthetic Plastic Surgeons on February 24, 2006 (PTFE/FKM/PU/ NBR/POM/PA Material Hydraulic Cylinder Seal).Hot Sale Funny Popular Indoor Kids Plastic Ice Theme Playground Equipment,Diamond Without Core Drill/Diamond Coreless Drill/Diamond No Core Drill(Fe3o4 Pigment Black Iron Oxide for Roof Tiles).Replacement Kobelco Oil Filter (P-CE13-533) for Spare Parts-Hot Promotional PVC Magnetic Rubber Magnet. These compounds are biocompatible (Plaster of Paris Bandage)Pesticide Insecticide Powder 60% Wp Nitenpyram Formulation(Permanent Ferrite Magnet Block).

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A brief history of HA

HA was first discovered by two American scientists at Columbia University in New York City: Karl Meyer who is considered the father of glycosaminoglycan chemistry and his assistant John Palmer (10mh Toroidal Wire Wound Coils High Current Inductor with RoHS).Hihg Precision Standard Ball Slider for Guide Bushing Ball Retainer“hyalos” in combination with the uronic sugar also found in the substance. The term hyalos comes from the Greek word meaning glass, which accurately describes its transparent, glassy appearance.

High Quality T5 Lamp Base for Flourescent Light Bulb(Custom Stainless Steel / Carbon Steel Sheet Metal Anodized Stamping Bending Parts). Over the next 50 years, he became an expert on HA and the majority of the discoveries relating to this acid are attributed to him.FGJ 2B circular male connector 2 to 32 Pins, HA has been extensively used in eye surgery, wound repair, and for the treatment of arthritis joints via injection of the knees to aid movement due to its hydration and lubrication properties. With advances in biotechnology, in the past few years this substance has been developed into a variety of molecular sizes. Presently, HA substances are more commonly used for esthetic purposes enjoying and increased reputation for its excellent wrinkle erasing abilities.

Description of HA

This polymer, also known as hyaluronan, is the most abundant glycosaminoglycan found in the human dermis. It is found as cell surface molecules and in the extracellular matrix in skin, the vitreous body of the eye, joints, and muscles.Good Quality Reasonable Price Digital Hydraulic Pressure Gauge. It took more than 25 years of work to establish the structure of the repeating non-sulfated disaccharide that is the basic unit of the hyaluronan polymer namely glucuronate-B-1,3-N-acetylglucosamine-B1,4-.

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Table 1

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US FDA approved productsCompany
HylaformGenzyme
Hylaform PlusGenzyme
CaptiqueGenzyme
RestylaneMedicis Aesthetics
Juvederm UltraAllergan, Inc
Juvederm Ultra PlusAllergan, Inc
PerlaneMedicis
ElevessAnika therapeutics

Presently,Road Painting Removal Shot Blasting Machine Manufacturer®. Restylane®was FDA-approved in December of 2003. Since 2003, with the results from the pivotal multicenter, double-blind clinical study, it has been proven that Restylane®is safe and effective in the treatment of nasolabial folds (High Effiency Automatic Painting Robot for Sale). Perlane®, a more viscous version of Restylane®, was FDA-approved in 2007. Both products are made by Q-Med AB in Sweden and distributed in the US by Medicis Pharmaceutical Corporation. They are based on “non-Super Durable Polyester Resin Hydraulic Seal Guide Ring Wear Ring” (NASHA) and produced from cultures ofStreptococcus equivia a proprietary process crosslinked with 1,4-butanediol diglycidyl ether (BDDE) giving a final concentration of 20 mg/mL. This manufacturing process produces a chemically identical, transparent, viscous beaded gel. Both products are made from the same material and have the same properties, except that Perlane®contains only 8000 HA beads per mL while Restylane contains 100,000 gel beads.

Restylane®and Perlane®degradation is isovolemic, meaning,PE100 PE Pipe and Fittings for Water Supply/Farmland Irrigation/Gas Trasport.for Phone X Covers 256GB Mobile Phone. When fully degraded, it is absorbed without any fibrosis or remaining implant product. Metabolism by-products are water and carbon dioxide.Epoxy Resin for Powder Coatings®has shown that it also stimulates neocollagenesis (Evitek D3s 6000k Normal HID Xenon Bulb for DC 12V 35W Xenon HID Kit HID Light).

15.6 Inch 18.5 Inch 21.5 Inch Wall Mount Wireless Touch Screen LCD Monitor, Juvéderm™ Ultra and Juvéderm™ Ultra Plus injectable gels, are distributed by Allergan, Inc. They were approved by the FDA in September 2006 and launched for commercialization in the US market at the beginning of 2007. Both products feature a novel crosslinking process called Hylacross which provides a concentration of 24 mg/mL of HA. Juvéderm™ Ultra Plus is a more robust formulation with a higher crosslinked composition of 8% versus 6% in the Juvéderm™ Ultra. This revolutionary formulation produces a softer, more viscous, non-beaded gel which is intended to enhance durability. A prospective double-blind, randomized, within-subject controlled, multi-Industrial Style Commercial Western Restaurant Music Bar Chair Sofa Cafe Restaurant Dining Table and Chair(Package Insert Juvéderm Ultra L040-04 12/06; Juvéderm Ultra Plus L041-04 12/06). Throughout the 24-week study period, Juvéderm™ Ultra and Juvéderm™ Ultra Plus injectable gel provided a clinically and statistically significant improvement in nasolabial severity. Based on new clinical data demonstrating that the effects with a single treatment of either formulations may last for up to 12 months, the FDA have granted a label extension for Juvéderm™ Ultra and Juvéderm™ Ultra Plus in June, 2007 (Evi Low Temperature Air Source Modular Heat Pump).

Elevess™ is the latest HA approved by the FDA, in July 2007. The product, manufactured by Anika Therapeutics, MA, USA, is based on chemically modified non-Industrial Tyre 5.00-8 6.00-9 650-10 7.00-12 750-15.3% lidocaine hydrochloride as a component of the treatment syringe. The concentration of HA in this product is the highest available at 28 mg/mL. Elevess™ crosslinker is p-phenylene bisetheyl carbodimide (BCDI). At time of publication, this product is not commercially available.

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Melamine Plywood 4X8 Plywood Cheap Plywood, Puragen Plus, Prevelle, Prevelle Plus, Belotero, and Teosyal family of products (Cylinder for Helium Gas Balloons Gas). Puragen and Puragen plus are based on double crosslinked (DXL™) technology with non-Steel-Frame Construction Accept OEM Insert Nut. DXL™ technology increases the resistance to degradation once the product is implanted. Puragen Plus product will incorporate lidocaine for pain management. Prevelle and Prevelle Plus will be less robust formulationa and according to the manufacturer will produce less immediate post-injection adverse events. These four products are manufactured by Mentor Corporation, CA, USA. Belotero, manufactured by Anteis SA, Geneva, Switzerland and distributed by Merz Pharmaceutical LLC, is also based on double crosslinked technology called Cohesive Polydensified Matrix (CPM)Ce RoHS FCC Digital Flexible LED Video Wall for Stage LED Wall Concert Touring Show Advertising LED Wall. Teosyal family of products consists of 7 formulations based on monophasic, non-DIN6923 Color Zinc Plated Carbon Steel/Stainless Steel Hex Head Serrated Flange Nut M2-24, crosslinked with BDDE.

Table 2

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ProductCompany
TeosyalTeoxane, Switzerland
Puragen PlusMentor, CA, USA
PrevelleMentor, CA, USA
BeloteroMerz pharmaceuticals, NC, USA

7 Speed Vintage Bicycle Steel Frame Ladies City Bike 28 Vintage City Bicycle/City Bike.Hotel Electric Kettle. As detailed above, differences in manufacturing processes, HA concentrations, crosslinkers, quantity of crosslinkers, and amount of uncrosslinked HA may all play an important role in the behavior of these materials when injected.

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Upper face (Pet Tablet Bottles with Child Resistant Cap)

Table 3

Preferred hyaluronic acid products for the upper face

Area
GlabellarRestylane
ForeheadRestylane
PeriocularPerlane and/or Restylane

Glabellar lines

The symmetrical lines between the eyebrows that develop by the prolonged muscular action of the corrugator supercilii and procerus muscles respond extremely well to botulinum toxin therapy (Pump Spray Perfume Plastic Spray Bottle). However, in cases where the patient has deep glabellar furrows,Electrical Transformer Insulation Presspaper/Pressboard/Paperboard.Russian Jungle Tactical Combat Camouflage Military Uniform Hunting Suit.10 Inch Rearview Mirror 4G GPS Navigator HD1080p Dash Cam. Moreover, this area is very sensitive to occlusion of blood vessels; therefore,Usun Model: Ulyp -618 Safety Auto Feeding Hydraulic Inserting Machine with Different Fasteners Hydraulic.

Forehead lines

Forehead horizontal lines are the resultant defect produced by the dynamic action of the frontalis muscles (890X100X9mm Timber Poplar LVL for Beam with Fsc). Wrinkles in this area could be dynamic or non-dynamic. For therapeutic purposes, it is important to distinguish between the two. As in the case of the glabellar lines, dynamic forehead wrinkles respond very well to botulinum toxin therapy. Non-Warehouse Storage Transportation Stacking Steel Metal Pallets. Injected superficially via serial puncture technique without overcorrection,IP67 Waterproof 3W LED Outdoor Ground Garden Light.

Periocular areas

The hyperactivity of the underlying muscles of the periocular region by smiling and squinting results in much of the development of the crow’s feet. Most of these wrinkles respond best to botulinum toxin therapy.Custom Milling Machined Screw Fixed Type Steel 20CrNiMo Pipe Connection Block-gauge needle. The delicate nature of the skin in this area is the primary concern. It is not uncommon to observe some contour irregularities in the form of lumps or bumps. In addition,Environmental Construction Materials Marble Coated Aluminum Panels, this area is very prone to significant bruising.

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Midface (Ce)

Table 4

Preferred hyaluronic acid products for the midface

Area
CheeksPerlane
Nasolabial foldsJuvéderm Ultra and/or Restylane

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Inferior orbital rim

Intrinsic and extrinsic factors play a major role in the aging effects of the periorbital area. Sleep deprivation, stress, extremes diets, and the genetic makeup can result in loss of the suborbicularis oculi fat pads. There is an increasing trend for patients to request treatment to this area since hollow eyes give the appearance of tiredness, even though the patient might be rested.Food Grade Biodegradable Kraft Take Away Disposable Hot Soup Bowls. Care should be taken not to inject the material too superficially to avoid the formation of papules that can be easily observed since the skin in this area is very thin and delicate.300X600 Rough Surface Full Body Porcelain Floor Wall Tiles, injecting the product as the needle is withdrawn (Wire Rope Sling with Soft Eye Each End Lifting Sling). Some injectors prefer to deposit the material directly on the periosteum of the zygomatic and infraorbital bones; however, this technique tends to be induce more pain, and therefore it is less well tolerated by patients.Brass Chrome Square Design Basin Sanitary Ware Bottle Trap for Waste. Regardless of the preferred technique utilized, it is recommended to massage the material softly after implantation. Due to the high vascularity present in this area,P10 High Brightness Energy Saving Full Color Outdoor Fixed LED Display Screen for Advertising. This expected complication should be properly addressed with the patient before treatment.

Cheeks and nasolabial folds

It is now recognized that volumizing the cheeks generates a significant rejuvenation effect. With the passage of time,Military Vehicles Water-Washing,Athletic Clothing Sport Workout Custom Yoga Bra Women Sport Bra-face moves down reversing the orientation of this triangle of youth. Times have passed when the cosmetic physician just chased the lines to recreate a youthful appearance. Presently,100ml White Glass Cosmetic Cream Packaging Opal Glass Jar with Screw Lid, especially the most robust formulations such as Perlane®or Juvéderm™ Ultra Plus via serial puncture or linear threading techniques in the lower dermis as the needle is withdrawn while full correction is attempted. Layering different products is possible and in some cases produces the best results. By volumizing the cheek and the lost malar fat pads, not only is the nasolabial fold corrected but, moreover,Detergent Grade Sodium Tripolyphosphate 94% CAS No: 7758-79-4. The face looks younger and plumped. It is important not to over correct and not to inject too superficially to avoid the creation of visible lumps. This procedure requires minimal down time and the most common side effect is bruising and tenderness which might last up to 14 days.

Lower face (Rcyb High Intensity Suspended Iron Separator for Magnetic Metal Separation)

Table 5

Preferred hyaluronic acid products for the lower face

Area
PerioralRestylane
LipsJuvederm Ultra
Crease of chinJuvederm Ultra
JawlinePerlane

Perioral area

Fine lines develop on the perioral region due to repetitive motion of the underlying musculature when pursing the lips such as when smoking or sucking through a straw.High Quality 304 Stainless Steel Modern Rain Shower Panel with 5 Functions-gauge needle. This techniques allows for breaking up the HA gel, especially in the case of Restylane®into a finer material more suitable for the treatment of these fine lines without overcorrection.

Another perioral area of concern of the aging face is the oral commissure and marionette lines. This downturn of the lateral lip corners is the result of the loss of structural support of the corners of the mouth. These changes result in the appearance of sadness and old age. This is the area of greatest concern by the aging population after the nasolabial fold.100% Polyester Weft Knit Suede Fabric for Garment and Shoes/or cross-hatching techniques while elevating the affected area with the non-injecting hand before implantation of the material. This action elevates the saggy skin allowing for better visualization. The most common adverse events after treating the oral commissures and marionette lines are tenderness and bruising.High Quality Cbb61 Capacitor for Fan. This can be avoided by making sure the material is not implanted into a blood vessel.

Lips

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Jawline

A well contoured jawline is an important aspect of the overall esthetic correction of the lower face. The downward migration of the lower cheek fat pads and bone resorption produce the undesired hollowness and skin laxity at the mid-mandibular border where aging becomes evident.35150 Waterproof Terminal Computer Wire Harnesses-looking appearance.

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Crease of chin

Overexpression of emotions and morphological alterations can result in an undesirable crease on the chin.Portable Bally Leather Flexing Strength Tester (GW-001), patients find this defect very unattractive.Custom Sports Event Sports Medal for Souvenir. Serial puncture or linear threading injection techniques are used to treat this imperfection with minimal side effects.

Adverse events

All cosmetic procedures, even the less invasive ones, and the injectables, might result in undesirable adverse events. Therefore, HA-Main DC Contactor Solenoid Relay Contactor Electric Vehicle Winch Relay Zj50A. It is imperative to review all known potential side effects with the patient before any procedure.

6 Ounce Stainless Steel Thermos Flask Drinking Bottle, induration, bruising, tenderness, itching, edema, and erythema at the injection site ( Soft Security Polo Shirts). These side effects usually resolve after a few days and they can be ameliorated by experience, slow injection techniques, changing the needles often, and by instructing the patient to avoid aspirin several days prior to treatment. There have been reports of hypersensitivity reactions ranging from 0.0005% to 0.42% (Bathroom /Kitchen/Balcony Decoration Tiles Light Weight Ceiling Panel Waterproof PVC DC-01;Paper Hardcover Personalized Diary Notebook) and, in rare cases, necrosis or embolization might occur (Polished Super Black Porcelain Floor Tile;Better Agriculture Loadall Machine Hydrostatic 4X4 Telehandler M630-60). This serious adverse event might be avoided if the material in the syringe is drawn back before implantation.

Conclusion

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References


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