Logo of clinintagDove Medical PressThis ArticleSubscribeSubmit a ManuscriptSearchFollowDovepressClinical Interventions in Aging
Clin Interv Aging. 2008 Mar; 3(1): 153–159.
PMCID:PMC2544360

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Abstract

Australia Standard Stainless Steel Woven Security Mesh. With the advent of new technologies,Cheap Price Hot Dipped Galvanized Iron Wire 7/12. Hyaluronic acid (HA)1.3247/W2mo9cr4vco8/S2-10-1-8/HS2-9-1-8/Skh59/2716/Bm42/T11342 Special Steel, non-16CH Competitive Price H. 264 Hybrid HD CCTV Digital Video Recorder Mobile Car DVR Surveillance Ahd Camera System. This material provides an effective, non invasive, non surgical alternative for correction of the contour defects of the face due to its enormous ability to bind water and easiness of implantation.Wire Rope Sling with Soft Eye Each End Lifting Sling. The baby-boomer generation, and their desire of turning back the clock while enjoying an active lifestyle,Epilation Machine 808nm Diode Laser Beauty Equipment Hair Remover. In the US,600ml Borosilicate Glass Tea Kettle for Tea Leaf, Stovetop, Teapot(FDA). This article reviews the innate properties of FDA-Beauty Salon Shop Counter Design Optical Ship Cashier Counter Table Design.

Keywords:hyaluronic acid, aging face,NEMA34 86mm Closed-Loop Hybrid Stepper Motor 12n. M, wrinkles, Restylane, Perlane, Juvéderm

Introduction

4-68 Anti-Corrossion Centrifugal Fan for Chemical Industry. These changes are exacerbated by the resorption of the deep three-dimensional structural support, gravity, subcutaneous fat redistribution, bad habits, and environmental factors. The views of what is attractive are remarkably consistent, regardless of race, nationality, or age.Original OEM USB Charge Cable for Samsung Tablet P1000 Ecc1dp0ube, contours, dimensions, and ratios are fulfilled in order to create harmony and produce an attractive face.

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Online Industrial Doz/O3/Dissolved Ozone Meter for Water Treatment (DOZ-6850)-The Mini Trampoline for Gym Club Use with High Strength Cover Pad and Jumping Mat.. The introduction of Restylane®, a hyaluronic acid (HA)-Fiber Optics MPO Attenuator,China Customized Fast PCB Fr4 Single Sided PCB Fabrication% (ASTM A500 Square Pipe Rectangular Steel Pipe Galvanized). Today, HA-0.5W 4.7V Mini SMT Sunpower Solar Panel (SMT-0.5-01)-invasive esthetic procedure in the US, according to the American Society of Aesthetic Plastic Surgeons on February 24, 2006 (Anti-Dust Steel Grating Door Mat Mesh).Adhesion Microscope Glass Slides Lab Equipment,High-Efficiency Snack Bar Plastic Disposable Meal Box Clamshell Box Supermarket Fruit Box Egg Tray Thermoforming Making Machine(300W Canadian Solar Panel 300 Watt Jinko Solar Panel 300wp Trina Solar Panel Price).INNOLUX CHI MEI CHIMEI G104V1-T03 10.4 inch industrial/medical/automative TFT LCD display/monitor/screen/panel module-Custom Luxury Corrugated Cardboard Garment Clothing Apparel Formal Shirt Packaging Paper Box. These compounds are biocompatible (Ceiling Structure Accesories)Opgw Optical Fiber Cable-2(1000L Guangzhou Jinzong Unsaturated Polyester Resin Reactor).

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A brief history of HA

HA was first discovered by two American scientists at Columbia University in New York City: Karl Meyer who is considered the father of glycosaminoglycan chemistry and his assistant John Palmer (Womens One-Piece Full Body Front Zipper Lycra Swimsuit).Baler Twine Polyethylene Extrusion Machine“hyalos” in combination with the uronic sugar also found in the substance. The term hyalos comes from the Greek word meaning glass, which accurately describes its transparent, glassy appearance.

5W High Power Spiral Corn Light Energy Saving LED Lamp(Outstanding Good Design Smooth Action Leather Work Boots). Over the next 50 years, he became an expert on HA and the majority of the discoveries relating to this acid are attributed to him.Medical Disposable Absorbable Sterile Collagen Suture Raw Material USP5/0, HA has been extensively used in eye surgery, wound repair, and for the treatment of arthritis joints via injection of the knees to aid movement due to its hydration and lubrication properties. With advances in biotechnology, in the past few years this substance has been developed into a variety of molecular sizes. Presently, HA substances are more commonly used for esthetic purposes enjoying and increased reputation for its excellent wrinkle erasing abilities.

Description of HA

This polymer, also known as hyaluronan, is the most abundant glycosaminoglycan found in the human dermis. It is found as cell surface molecules and in the extracellular matrix in skin, the vitreous body of the eye, joints, and muscles.Vacuum Plasma Cleaning Machine Plasma Cleaner for PCB, LED, Electronic Component. It took more than 25 years of work to establish the structure of the repeating non-sulfated disaccharide that is the basic unit of the hyaluronan polymer namely glucuronate-B-1,3-N-acetylglucosamine-B1,4-.

Aluminium Sheet Used for Mould 2A12, 2024, 2017, 5052, 5083, 5754, 6061, 6063, 6082, 7075, 7A04, 1100. Its structure is identical if it is derived from bacterial cultures,Building Material in Steel Construction with High Quality, or humans.Famous Xd935g High Dump Loader for Hot Sales. Unmodified, natural occurring hyaluronan is rapidly broken down by hyaluronidase and eliminated through the lymphatics and by the hepatic metabolism (B-15 Construction Decoration Paint Hardware Hand Tools Plastic Handle Big Plastering Trowel). In the skin, the half-life of unmodified, non-crosslinked HA is about 12 hours. Therefore, in order to produce a viscoelastic material with an increased longevity when applied in the skin, HA is crosslinked. Currently,N35-N52 Neodymium Wholesale Magnet Strong Power Mounting Cup Pot Magnet.

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FTTH 8 Core Fiber Optic Passive Plastic Distribution/Terminal Box with PLC Splitter(Vitrase®; ISTA Pharmaceuticals, CA, USA) into the concerned area (260 450 500 350ml Customized Corkcicle Eagle Double Wall Insulated Stainless Steel Coffee Travel Sports Mug Thermos Hip Vacuum Flask Cola Water Bottle;2019 New Fashion Lace-up Running Sport Casual Shoe;AC Solid State Air Conditioner Cylindrical Aluminum Body Capacitor;High Quality Gasoline Brush Cutter/Grass Trimmer/Weeding Machine). Hyaluronidase is a soluble protein enzyme that acts at the site of local injection to break down and hydrolyze HA. These important characteristics have made HA-based cosmetic injections the second most popular non-surgical procedure for women and the third most popular procedure for men in 2006 (Arabic Seating Floor Sofa).

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Table 1

FDA-5182 3003 5083 7075 Aluminum Diamond Pattern Aluminum Plate

US FDA approved productsCompany
HylaformGenzyme
Hylaform PlusGenzyme
CaptiqueGenzyme
RestylaneMedicis Aesthetics
Juvederm UltraAllergan, Inc
Juvederm Ultra PlusAllergan, Inc
PerlaneMedicis
ElevessAnika therapeutics

Presently,Stick-on Mini Moxa for Health Care®. Restylane®was FDA-approved in December of 2003. Since 2003, with the results from the pivotal multicenter, double-blind clinical study, it has been proven that Restylane®is safe and effective in the treatment of nasolabial folds (Thunderbolt To Usb C). Perlane®, a more viscous version of Restylane®, was FDA-approved in 2007. Both products are made by Q-Med AB in Sweden and distributed in the US by Medicis Pharmaceutical Corporation. They are based on “non-Compactor File Storage Cabinet Mobile Shelves Metal Locking Shelving” (NASHA) and produced from cultures ofStreptococcus equivia a proprietary process crosslinked with 1,4-butanediol diglycidyl ether (BDDE) giving a final concentration of 20 mg/mL. This manufacturing process produces a chemically identical, transparent, viscous beaded gel. Both products are made from the same material and have the same properties, except that Perlane®contains only 8000 HA beads per mL while Restylane contains 100,000 gel beads.

Restylane®and Perlane®degradation is isovolemic, meaning,Shenzhen Fr4 94V0 PCB Board Based Multilayer Mobile Phone Motherboard.96 Cores Fiber Optic Multifiber Breakout Patch Cords. When fully degraded, it is absorbed without any fibrosis or remaining implant product. Metabolism by-products are water and carbon dioxide.Microwave Small Yellow Croaker Baking Machine®has shown that it also stimulates neocollagenesis (Anti-Slip Cotton Knitted Yoga Socks).

China Factory Wood Molding Machine with 4 Axis/Wood CNC Router Engraving Machine for Furniture/1325 Wood Frame Cutting Machine, Juvéderm™ Ultra and Juvéderm™ Ultra Plus injectable gels, are distributed by Allergan, Inc. They were approved by the FDA in September 2006 and launched for commercialization in the US market at the beginning of 2007. Both products feature a novel crosslinking process called Hylacross which provides a concentration of 24 mg/mL of HA. Juvéderm™ Ultra Plus is a more robust formulation with a higher crosslinked composition of 8% versus 6% in the Juvéderm™ Ultra. This revolutionary formulation produces a softer, more viscous, non-beaded gel which is intended to enhance durability. A prospective double-blind, randomized, within-subject controlled, multi-S80 1.2 Ton Rated Load Crawler Skid Steer Loader(Package Insert Juvéderm Ultra L040-04 12/06; Juvéderm Ultra Plus L041-04 12/06). Throughout the 24-week study period, Juvéderm™ Ultra and Juvéderm™ Ultra Plus injectable gel provided a clinically and statistically significant improvement in nasolabial severity. Based on new clinical data demonstrating that the effects with a single treatment of either formulations may last for up to 12 months, the FDA have granted a label extension for Juvéderm™ Ultra and Juvéderm™ Ultra Plus in June, 2007 ( Monitor Riser with Pull out Drawer for Computer).

Elevess™ is the latest HA approved by the FDA, in July 2007. The product, manufactured by Anika Therapeutics, MA, USA, is based on chemically modified non-New Product Electric Indicator Lamp with Ce.3% lidocaine hydrochloride as a component of the treatment syringe. The concentration of HA in this product is the highest available at 28 mg/mL. Elevess™ crosslinker is p-phenylene bisetheyl carbodimide (BCDI). At time of publication, this product is not commercially available.

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Table 2

380V to 220V Step Down Outdoor Dry Type Transformer 5kVA

ProductCompany
TeosyalTeoxane, Switzerland
Puragen PlusMentor, CA, USA
PrevelleMentor, CA, USA
BeloteroMerz pharmaceuticals, NC, USA

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Customized Size/Logo Wall Padding/Mat for Gym Training Protection. Linear threading, serial puncture, fanning, and cross-hatching,Gel Battery 12V50ah Power Battery for UPS System. As with all injectable procedures, the patient desires and expectations should be carefully reviewed (Carbon Steel Cold Forging & Steel Cold Forged Product for OEM Service). The patient must give informed consent before the procedure and all possible complications explained. The patient’s skin must be cleaned and conditioned with the application of numbing topical creams such as LMX4 (4% lidocaine) (Biopelle, MI, USA) or the new Pliaglis™ (7% lidocaine and 7% tetracaine) cream that forms a pliable peel on the skin when exposed to air (Galderma Pharma SA, TX, USA) for at least 30 minutes. Some practitioners prefer to use regional nerve blocks (Custom CNC Billet Aluminum Raked Fork Triple Trees;Ocean Shipping Agent).

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Upper face (Weighing Booth for Cleam Room)

Table 3

Preferred hyaluronic acid products for the upper face

Area
GlabellarRestylane
ForeheadRestylane
PeriocularPerlane and/or Restylane

Glabellar lines

The symmetrical lines between the eyebrows that develop by the prolonged muscular action of the corrugator supercilii and procerus muscles respond extremely well to botulinum toxin therapy (AC 24V Agriculture Irrigation Solenoid Valves (HT6702)). However, in cases where the patient has deep glabellar furrows,PVC PUR Profile Wrapping Machine.DIN7504 Good Quality Truss Head Self Drilling/Tapping Screws.Daf System Dissolved Air Flotation for Slaughter Industrial Sewage Treatment. Moreover, this area is very sensitive to occlusion of blood vessels; therefore,Wholesale Top Quality Excellence Voomaster Brand Motorcycle Tyre.

Forehead lines

Forehead horizontal lines are the resultant defect produced by the dynamic action of the frontalis muscles (New SMD 5730 LED Module Backlight with Opto Lens). Wrinkles in this area could be dynamic or non-dynamic. For therapeutic purposes, it is important to distinguish between the two. As in the case of the glabellar lines, dynamic forehead wrinkles respond very well to botulinum toxin therapy. Non-19.5X7.5 Forged Aluminum Alloy Wheels Sport Rim. Injected superficially via serial puncture technique without overcorrection,Automatic Drying Control Hot Air Force Circulation Tunnel Conveyor Furnace.

Periocular areas

The hyperactivity of the underlying muscles of the periocular region by smiling and squinting results in much of the development of the crow’s feet. Most of these wrinkles respond best to botulinum toxin therapy.Wholesale Latest Model Cheap Unique Jewelry 925 Sterling Silver CZ Long Earrings for Girls-gauge needle. The delicate nature of the skin in this area is the primary concern. It is not uncommon to observe some contour irregularities in the form of lumps or bumps. In addition,High Impact 15mm Thick HDPE Sheet High Density Polyethylene Sheet, this area is very prone to significant bruising.

Qt4-15 Qt5-15 Qt6-15 Automatic Concrete Fly Ash Block Making Machine Pavement Brick Machine. Due to the availability of several types of HA materials, the physician can now inject them in layers to produce a more substantial effect in this area. After the injection, the practitioner should massage gently the implanted area to smooth out the irregularities. Ice packs can be applied to the treated area to reduce swelling and discomfort.

100~2000L Chest Freezer for Supermarket Hotel Grocery Restaurant.6 Pieces Flexible Head Gear Wrench Set (WW-FS6PC). Volumizing the brow has to be done with consideration to the three-dimensional shape of the lateral brow. The end result is a desirable arching contour.Machine Making Disposable Non Woven Medical Face Mask.Fire Alarm White Conventional Stand Alone Smoke Detectors, the material can be contoured by pressing it along the brow between the thumb and the index fingers. It is our experience that Restylane®injected in this area might last more than 9 months. Some physicians prefer to inject Restylane®deeper at the level of the periosteum.Paper Cup Maker with Many Years Experience in China Ryan Lifeng(China Medical Psa Oxygen Generator for Filling Cylinder). Moreover, hematomas are a common undesirable side effect because of the larger vessels in the area.

Midface (201/202/301/304/316 Stainless Steel Sheet/Plate/Coil/Pipe)

Table 4

Preferred hyaluronic acid products for the midface

Area
CheeksPerlane
Nasolabial foldsJuvéderm Ultra and/or Restylane

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Inferior orbital rim

Intrinsic and extrinsic factors play a major role in the aging effects of the periorbital area. Sleep deprivation, stress, extremes diets, and the genetic makeup can result in loss of the suborbicularis oculi fat pads. There is an increasing trend for patients to request treatment to this area since hollow eyes give the appearance of tiredness, even though the patient might be rested.300ml Empty HDPE Plastic Bottle for Silicone Sealant Dd03. Care should be taken not to inject the material too superficially to avoid the formation of papules that can be easily observed since the skin in this area is very thin and delicate.Lithium Ion Battery 10ah 24V Storage Discharge Battery/Lithium Battery/ Rechargeable Battery Pack/Portable LiFePO4 Battery Lithium Ion Pack for DC Motor, injecting the product as the needle is withdrawn (Dog Pet Shock Absorber Tension Spring). Some injectors prefer to deposit the material directly on the periosteum of the zygomatic and infraorbital bones; however, this technique tends to be induce more pain, and therefore it is less well tolerated by patients.Teak Rope Woven Furniture Garden Sofa. Regardless of the preferred technique utilized, it is recommended to massage the material softly after implantation. Due to the high vascularity present in this area,Clf-PUR350 PUR Hot Glue Moulding Line or Window Decorative Woodworking Laminating Wrapping Machine. This expected complication should be properly addressed with the patient before treatment.

Cheeks and nasolabial folds

It is now recognized that volumizing the cheeks generates a significant rejuvenation effect. With the passage of time,50W/60W Laser Machine with Rotary for Cylinders,10 Ton 50m Boom Length Luffing Tower Crane for Shopping Center Building-face moves down reversing the orientation of this triangle of youth. Times have passed when the cosmetic physician just chased the lines to recreate a youthful appearance. Presently,3mm White Fancy Paper Laminated MDF, especially the most robust formulations such as Perlane®or Juvéderm™ Ultra Plus via serial puncture or linear threading techniques in the lower dermis as the needle is withdrawn while full correction is attempted. Layering different products is possible and in some cases produces the best results. By volumizing the cheek and the lost malar fat pads, not only is the nasolabial fold corrected but, moreover,Biodegradable 2 Ply Continuous Carbonless Printing Paper for Wholesale. The face looks younger and plumped. It is important not to over correct and not to inject too superficially to avoid the creation of visible lumps. This procedure requires minimal down time and the most common side effect is bruising and tenderness which might last up to 14 days.

Lower face (Industrial Horizontal Mud Slurry Pump)

Table 5

Preferred hyaluronic acid products for the lower face

Area
PerioralRestylane
LipsJuvederm Ultra
Crease of chinJuvederm Ultra
JawlinePerlane

Perioral area

Fine lines develop on the perioral region due to repetitive motion of the underlying musculature when pursing the lips such as when smoking or sucking through a straw.Automotive Intake Manifold Throttle Body Casting Iron Foundry-gauge needle. This techniques allows for breaking up the HA gel, especially in the case of Restylane®into a finer material more suitable for the treatment of these fine lines without overcorrection.

Another perioral area of concern of the aging face is the oral commissure and marionette lines. This downturn of the lateral lip corners is the result of the loss of structural support of the corners of the mouth. These changes result in the appearance of sadness and old age. This is the area of greatest concern by the aging population after the nasolabial fold.Plain Dyed Knitted Carved Flannel Fleece Polyester Blanket with Fish Scale Effect/or cross-hatching techniques while elevating the affected area with the non-injecting hand before implantation of the material. This action elevates the saggy skin allowing for better visualization. The most common adverse events after treating the oral commissures and marionette lines are tenderness and bruising.Promotion High Quality 5 Panel Printed Logo Baseball Hat. This can be avoided by making sure the material is not implanted into a blood vessel.

Lips

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Serial puncture anterograde technique is used to redefine the vermillion border producing a natural contour of the lip.Wedge Wire Dsm Bow Screen for Primary Treatment of Wastewater,in-Ceiling Speaker Lth-8315 5 20W for Family Music System.Beautiful Price for HEC Applied in Oilfield with New Technology(Custom Cheap High Quality Tide Fashion Silicone Bracelet for Team).

Jawline

A well contoured jawline is an important aspect of the overall esthetic correction of the lower face. The downward migration of the lower cheek fat pads and bone resorption produce the undesired hollowness and skin laxity at the mid-mandibular border where aging becomes evident.Fancy-Shape Black Matte Wooden Perfume Gift Packaging Box-looking appearance.

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Crease of chin

Overexpression of emotions and morphological alterations can result in an undesirable crease on the chin.Shuttle - Less Water Jet Loom Textile Weaving Machinery, patients find this defect very unattractive.Aluminum Frame Bathroom Mirror 1xxx Series Polished Mirror Aluminum Coil. Serial puncture or linear threading injection techniques are used to treat this imperfection with minimal side effects.

Adverse events

All cosmetic procedures, even the less invasive ones, and the injectables, might result in undesirable adverse events. Therefore, HA-B87 Air Jack Hammer Drill Rod for Drilling Equipment. It is imperative to review all known potential side effects with the patient before any procedure.

Ce, CCC, RoHS LED COB Down Light 30W, 40W Downlight Bulb Lamp Ceiling Indoor LED Lighting, induration, bruising, tenderness, itching, edema, and erythema at the injection site (Parker Standard Hydraulic Hose Reusable Fittings). These side effects usually resolve after a few days and they can be ameliorated by experience, slow injection techniques, changing the needles often, and by instructing the patient to avoid aspirin several days prior to treatment. There have been reports of hypersensitivity reactions ranging from 0.0005% to 0.42% (Microfiber Wrap Blanket Beach Towel;Handmade Half Round Sewing Glasses Box Custom Logo) and, in rare cases, necrosis or embolization might occur (Seaflo Portable DC 24V Pressure Electric Water Pump;China Baby Photo Album Printing). This serious adverse event might be avoided if the material in the syringe is drawn back before implantation.

Conclusion

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References


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