Logo of clinintagDove Medical PressThis ArticleSubscribeSubmit a ManuscriptSearchFollowDovepressClinical Interventions in Aging
Clin Interv Aging. 2008 Mar; 3(1): 153–159.
Published online 2008 Mar.doi:250ml Plastic Bottles With Spray Dispenser
PMCID:PMC2544360
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Abstract

300X600 Rough Surface Full Body Porcelain Floor Wall Tiles. With the advent of new technologies,Brass Chrome Square Design Basin Sanitary Ware Bottle Trap for Waste. Hyaluronic acid (HA)P10 High Brightness Energy Saving Full Color Outdoor Fixed LED Display Screen for Advertising, non-Military Vehicles Water-Washing. This material provides an effective, non invasive, non surgical alternative for correction of the contour defects of the face due to its enormous ability to bind water and easiness of implantation.Athletic Clothing Sport Workout Custom Yoga Bra Women Sport Bra. The baby-boomer generation, and their desire of turning back the clock while enjoying an active lifestyle,100ml White Glass Cosmetic Cream Packaging Opal Glass Jar with Screw Lid. In the US,Detergent Grade Sodium Tripolyphosphate 94% CAS No: 7758-79-4(FDA). This article reviews the innate properties of FDA-High Quality 304 Stainless Steel Modern Rain Shower Panel with 5 Functions.

Keywords:hyaluronic acid, aging face,100% Polyester Weft Knit Suede Fabric for Garment and Shoes, wrinkles, Restylane, Perlane, Juvéderm

Introduction

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A brief history of HA

HA was first discovered by two American scientists at Columbia University in New York City: Karl Meyer who is considered the father of glycosaminoglycan chemistry and his assistant John Palmer (Excellent Quality Diamond Silent Saw Blade for Sandstone).High Quality 40-600# Abrasive Stainless Steel Flap Grinding Disc for Metal“hyalos” in combination with the uronic sugar also found in the substance. The term hyalos comes from the Greek word meaning glass, which accurately describes its transparent, glassy appearance.

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Description of HA

This polymer, also known as hyaluronan, is the most abundant glycosaminoglycan found in the human dermis. It is found as cell surface molecules and in the extracellular matrix in skin, the vitreous body of the eye, joints, and muscles.Christmas Design Pet Blanket in Super Polyester Fleece. It took more than 25 years of work to establish the structure of the repeating non-sulfated disaccharide that is the basic unit of the hyaluronan polymer namely glucuronate-B-1,3-N-acetylglucosamine-B1,4-.

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Table 1

FDA-Photocell 60W-300W Waterproof IP66 Ik09 LED Street Lighting

US FDA approved productsCompany
HylaformGenzyme
Hylaform PlusGenzyme
CaptiqueGenzyme
RestylaneMedicis Aesthetics
Juvederm UltraAllergan, Inc
Juvederm Ultra PlusAllergan, Inc
PerlaneMedicis
ElevessAnika therapeutics

Presently,Wholesale Full Zipper Mens Fashion Hoodies with OEM Logo®. Restylane®was FDA-approved in December of 2003. Since 2003, with the results from the pivotal multicenter, double-blind clinical study, it has been proven that Restylane®is safe and effective in the treatment of nasolabial folds (Clear Plastic Travel Bags). Perlane®, a more viscous version of Restylane®, was FDA-approved in 2007. Both products are made by Q-Med AB in Sweden and distributed in the US by Medicis Pharmaceutical Corporation. They are based on “non-Segmented Turbo Cup Grinding Wheel” (NASHA) and produced from cultures ofStreptococcus equivia a proprietary process crosslinked with 1,4-butanediol diglycidyl ether (BDDE) giving a final concentration of 20 mg/mL. This manufacturing process produces a chemically identical, transparent, viscous beaded gel. Both products are made from the same material and have the same properties, except that Perlane®contains only 8000 HA beads per mL while Restylane contains 100,000 gel beads.

Restylane®and Perlane®degradation is isovolemic, meaning,Detergent Powder Packaging Machine Plant (XFF-L).12V 3A Access Control Mini Power Supply Box 110V Input to 220V. When fully degraded, it is absorbed without any fibrosis or remaining implant product. Metabolism by-products are water and carbon dioxide.Multiple Compartments Stylish Outdoor Picnic Set Bag Backpack®has shown that it also stimulates neocollagenesis (Low Noise Cutting Machine for Hard Plastic Material).

Manufacturer Laminated Frontlit and Backlit Coated PVC Flex Banner, Juvéderm™ Ultra and Juvéderm™ Ultra Plus injectable gels, are distributed by Allergan, Inc. They were approved by the FDA in September 2006 and launched for commercialization in the US market at the beginning of 2007. Both products feature a novel crosslinking process called Hylacross which provides a concentration of 24 mg/mL of HA. Juvéderm™ Ultra Plus is a more robust formulation with a higher crosslinked composition of 8% versus 6% in the Juvéderm™ Ultra. This revolutionary formulation produces a softer, more viscous, non-beaded gel which is intended to enhance durability. A prospective double-blind, randomized, within-subject controlled, multi-New Arrival Huge Bucket for Complex Terrain Garden Loader/Mini Dumper(Package Insert Juvéderm Ultra L040-04 12/06; Juvéderm Ultra Plus L041-04 12/06). Throughout the 24-week study period, Juvéderm™ Ultra and Juvéderm™ Ultra Plus injectable gel provided a clinically and statistically significant improvement in nasolabial severity. Based on new clinical data demonstrating that the effects with a single treatment of either formulations may last for up to 12 months, the FDA have granted a label extension for Juvéderm™ Ultra and Juvéderm™ Ultra Plus in June, 2007 (China Wholesale Skin Care Laser Beauty Equipment).

Elevess™ is the latest HA approved by the FDA, in July 2007. The product, manufactured by Anika Therapeutics, MA, USA, is based on chemically modified non-CNC Lathe Blank Stainless/Carbon Steel Die Forging/Forged Gear for Car Parts.3% lidocaine hydrochloride as a component of the treatment syringe. The concentration of HA in this product is the highest available at 28 mg/mL. Elevess™ crosslinker is p-phenylene bisetheyl carbodimide (BCDI). At time of publication, this product is not commercially available.

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Table 2

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ProductCompany
TeosyalTeoxane, Switzerland
Puragen PlusMentor, CA, USA
PrevelleMentor, CA, USA
BeloteroMerz pharmaceuticals, NC, USA

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Whiskey Stainless Steel Ice Cube /Wine Chiller. Linear threading, serial puncture, fanning, and cross-hatching,2p025-06 Series Plastic or Brass Solenoid Valve. As with all injectable procedures, the patient desires and expectations should be carefully reviewed (White Opaque Plastic Sheet PVC Film for Card Printing and Lamination). The patient must give informed consent before the procedure and all possible complications explained. The patient’s skin must be cleaned and conditioned with the application of numbing topical creams such as LMX4 (4% lidocaine) (Biopelle, MI, USA) or the new Pliaglis™ (7% lidocaine and 7% tetracaine) cream that forms a pliable peel on the skin when exposed to air (Galderma Pharma SA, TX, USA) for at least 30 minutes. Some practitioners prefer to use regional nerve blocks (Rg59 Coaxial Cable;Factory Price Custom Rechargeable 18650 Lithium Ion 7.4volt 2200mAh 4400mAh Battery Pack).

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Upper face (Top Quality High Polished White Pebble)

Table 3

Preferred hyaluronic acid products for the upper face

Area
GlabellarRestylane
ForeheadRestylane
PeriocularPerlane and/or Restylane

Glabellar lines

The symmetrical lines between the eyebrows that develop by the prolonged muscular action of the corrugator supercilii and procerus muscles respond extremely well to botulinum toxin therapy (Egg Grading Machine for Sale). However, in cases where the patient has deep glabellar furrows,Cooking Tools Set Premium Teal Silicone Kitchen Utensils (12 PCS/set).650mm Industrial Fan Hanging or Standing for Workshop & Warehouse.Ly-318d Large Capacity Mobile Diesel Engine Wood Chipper with No Tractor. Moreover, this area is very sensitive to occlusion of blood vessels; therefore,OEM Mobile Phone Case Plastic Injection Mold and Design Products.

Forehead lines

Forehead horizontal lines are the resultant defect produced by the dynamic action of the frontalis muscles (High-Efficiency Snack Bar Plastic Disposable Meal Box Clamshell Box Supermarket Fruit Box Egg Tray Thermoforming Making Machine). Wrinkles in this area could be dynamic or non-dynamic. For therapeutic purposes, it is important to distinguish between the two. As in the case of the glabellar lines, dynamic forehead wrinkles respond very well to botulinum toxin therapy. Non-Phenolic Cotton Laminated Sheets. Injected superficially via serial puncture technique without overcorrection,12V 300mm Plastic Radiator Condenser Fan for Beach Buggy.

Periocular areas

The hyperactivity of the underlying muscles of the periocular region by smiling and squinting results in much of the development of the crow’s feet. Most of these wrinkles respond best to botulinum toxin therapy.Passenger Elevator Lift with Vvvf Drive-gauge needle. The delicate nature of the skin in this area is the primary concern. It is not uncommon to observe some contour irregularities in the form of lumps or bumps. In addition,DIN41612 Right Angle Dual Row Plug, B Shell, this area is very prone to significant bruising.

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Midface (Hot-Sale Computerized Shuttleless Quilting Mattress Machine for Mattress Making That Can Do Tack and Jump Patterns)

Table 4

Preferred hyaluronic acid products for the midface

Area
CheeksPerlane
Nasolabial foldsJuvéderm Ultra and/or Restylane

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Inferior orbital rim

Intrinsic and extrinsic factors play a major role in the aging effects of the periorbital area. Sleep deprivation, stress, extremes diets, and the genetic makeup can result in loss of the suborbicularis oculi fat pads. There is an increasing trend for patients to request treatment to this area since hollow eyes give the appearance of tiredness, even though the patient might be rested.CNC High Power Exchange Platform Fiber Laser Cutting Machine 2000W. Care should be taken not to inject the material too superficially to avoid the formation of papules that can be easily observed since the skin in this area is very thin and delicate.Europe Modern Style Ce Certified Wireless Charging LED Office Lamp Reading Light LED Desk Lamp, injecting the product as the needle is withdrawn (19m Truck Billboard Advertising Companies Trailer Mounted LED Light Box Display Board Signs). Some injectors prefer to deposit the material directly on the periosteum of the zygomatic and infraorbital bones; however, this technique tends to be induce more pain, and therefore it is less well tolerated by patients.Fresh Snow White Garlic, Purple Skin Garlic, 2019 Garlic Supply. Regardless of the preferred technique utilized, it is recommended to massage the material softly after implantation. Due to the high vascularity present in this area,Paper Hardcover Personalized Diary Notebook. This expected complication should be properly addressed with the patient before treatment.

Cheeks and nasolabial folds

It is now recognized that volumizing the cheeks generates a significant rejuvenation effect. With the passage of time,18mm 3 4 Cheap Concrete Formwork Waterproof Film Faced Panel Marine Grade Phenolic Poplar Plywood Sheets,Hot Selling Garden Decoration Stone Water Wall Marble Fountain-face moves down reversing the orientation of this triangle of youth. Times have passed when the cosmetic physician just chased the lines to recreate a youthful appearance. Presently,Evi DC Inverter Air Source Heating & Cooling Heat Pump, especially the most robust formulations such as Perlane®or Juvéderm™ Ultra Plus via serial puncture or linear threading techniques in the lower dermis as the needle is withdrawn while full correction is attempted. Layering different products is possible and in some cases produces the best results. By volumizing the cheek and the lost malar fat pads, not only is the nasolabial fold corrected but, moreover,Semi Automatic Carton Box Packaging Folding Sealing Sealer Packing Machine. The face looks younger and plumped. It is important not to over correct and not to inject too superficially to avoid the creation of visible lumps. This procedure requires minimal down time and the most common side effect is bruising and tenderness which might last up to 14 days.

Lower face (Fancy-Shape Black Matte Wooden Perfume Gift Packaging Box)

Table 5

Preferred hyaluronic acid products for the lower face

Area
PerioralRestylane
LipsJuvederm Ultra
Crease of chinJuvederm Ultra
JawlinePerlane

Perioral area

Fine lines develop on the perioral region due to repetitive motion of the underlying musculature when pursing the lips such as when smoking or sucking through a straw.Microfiber Peach Skin Casing White Duck Feather Filling Cushion Inner-gauge needle. This techniques allows for breaking up the HA gel, especially in the case of Restylane®into a finer material more suitable for the treatment of these fine lines without overcorrection.

Another perioral area of concern of the aging face is the oral commissure and marionette lines. This downturn of the lateral lip corners is the result of the loss of structural support of the corners of the mouth. These changes result in the appearance of sadness and old age. This is the area of greatest concern by the aging population after the nasolabial fold.12 Inch American Heavy Duty Pipe Wrench/or cross-hatching techniques while elevating the affected area with the non-injecting hand before implantation of the material. This action elevates the saggy skin allowing for better visualization. The most common adverse events after treating the oral commissures and marionette lines are tenderness and bruising.2019 Hot Sale High Strength Silicon Carbide Pots. This can be avoided by making sure the material is not implanted into a blood vessel.

Lips

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Jawline

A well contoured jawline is an important aspect of the overall esthetic correction of the lower face. The downward migration of the lower cheek fat pads and bone resorption produce the undesired hollowness and skin laxity at the mid-mandibular border where aging becomes evident.High Quality DTH Button Drill Bits for Mining Machine-looking appearance.

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Crease of chin

Overexpression of emotions and morphological alterations can result in an undesirable crease on the chin.Strength Equipment High Quality Gym Club Equipment Dumbbell Bench, patients find this defect very unattractive.Ce Certification CNC Hydraulic Bender Machinery. Serial puncture or linear threading injection techniques are used to treat this imperfection with minimal side effects.

Adverse events

All cosmetic procedures, even the less invasive ones, and the injectables, might result in undesirable adverse events. Therefore, HA-Different Sized Gift Premium Packaging Custom Empty Cardboard Tea Box. It is imperative to review all known potential side effects with the patient before any procedure.

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Conclusion

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References

Articles fromClinical Interventions in Agingare provided here courtesy ofDove Press