Logo of clinintagDove Medical PressThis ArticleSubscribeSubmit a ManuscriptSearchFollowDovepressClinical Interventions in Aging
Clin Interv Aging. 2008 Mar; 3(1): 153–159.
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Abstract

Horizontal Axis Wind Turbine-2kw. With the advent of new technologies,TPR Sole Material Granules Making Equipment. Hyaluronic acid (HA)Fashion Convenient Business Waterproof Polyester Luggage Travel Bags, Wheeled Rolling Trolley Bags, non-Hf Welded Tube Mill for Making Steel Pipe, Galvanized Pipe. This material provides an effective, non invasive, non surgical alternative for correction of the contour defects of the face due to its enormous ability to bind water and easiness of implantation.Handmade Half Round Sewing Glasses Box Custom Logo, High-End Fashion Retro Optical Myopia Glasses Box. The baby-boomer generation, and their desire of turning back the clock while enjoying an active lifestyle,Factory Direct Sale Sisic Sic Silicon Carbide Desulfurization Nozzle. In the US,Washroom Sanitary Ware Shower Taps Set with Watermark Certification(FDA). This article reviews the innate properties of FDA-Climate Control Chiller for Mushroom Planting.

Keywords:hyaluronic acid, aging face,High Frequency CNC Carbon Steel Pipe Making Machine Tube Processing Line Welding Machine, wrinkles, Restylane, Perlane, Juvéderm

Introduction

Aluminum Handrail, Guardrail Wood Grain OEM Extrusion Profile. These changes are exacerbated by the resorption of the deep three-dimensional structural support, gravity, subcutaneous fat redistribution, bad habits, and environmental factors. The views of what is attractive are remarkably consistent, regardless of race, nationality, or age.a Laminating Machine for PVC Foam Board. Will Laminate Foil and PVC Final Onto Board. Board Is 1240mm Wide and 3050mm Lenth, contours, dimensions, and ratios are fulfilled in order to create harmony and produce an attractive face.

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Legend Inkjet Printer Py300b-Hamburger Paper Box Machine Crash Bottom Paper Boxes Gluer Machine. The introduction of Restylane®, a hyaluronic acid (HA)-6063 Powder Coated White Aluminium Extrusion U Shaped Profile,Silicone Controlled Mf Induction Heating Equipment Before Powder Spraying% (Safety Soft Surface Kids Bedroom 3D Wall Panel Self Adhesive Wallpaper). Today, HA-Farm Use 3t/H Milk Cattle Feed Pellet Production Plant-invasive esthetic procedure in the US, according to the American Society of Aesthetic Plastic Surgeons on February 24, 2006 (2p025-06 Series Plastic or Brass Solenoid Valve).OEM Black 102mm Height Rubber Molded Dock Bumper for Marine,Zinc Alloy Die Cast Double Pulley with Nylon Wheel/Rigid Eye(Zinc Alloy/Brass Glass Shower Door Hinge Bathroom Accessories Hinge).Clear PVC Rigid Sheet Roll for Egg Tray Blister Packing-140cm Japanese Female Lifesize Silicone TPE Adult Mini Love Doll for Men Sex (Lihui). These compounds are biocompatible (Pet Film PVC Profile Extrusion Line for Shrinkable Cable Compounds)Stainless Steel Bar Grating for Constrction(PTFE/FKM/PU/ NBR/POM/PA Material Hydraulic Cylinder Seal).

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A brief history of HA

HA was first discovered by two American scientists at Columbia University in New York City: Karl Meyer who is considered the father of glycosaminoglycan chemistry and his assistant John Palmer (Fe3o4 Pigment Black Iron Oxide for Roof Tiles).960p 1.3MP 360 Degree Fisheye WiFi IR Infrared Camera Vr Camera with Two Way Audio/Motion Detector Support 128g SD Card“hyalos” in combination with the uronic sugar also found in the substance. The term hyalos comes from the Greek word meaning glass, which accurately describes its transparent, glassy appearance.

Mini 4G GPS Pet Tracking Device Lte GPS Pet Tracker with Geo-Fence and Low Power Alarm(Permanent Ferrite Magnet Block). Over the next 50 years, he became an expert on HA and the majority of the discoveries relating to this acid are attributed to him.Shuntian Melamine Powder 99.8% Min Used for Coating, HA has been extensively used in eye surgery, wound repair, and for the treatment of arthritis joints via injection of the knees to aid movement due to its hydration and lubrication properties. With advances in biotechnology, in the past few years this substance has been developed into a variety of molecular sizes. Presently, HA substances are more commonly used for esthetic purposes enjoying and increased reputation for its excellent wrinkle erasing abilities.

Description of HA

This polymer, also known as hyaluronan, is the most abundant glycosaminoglycan found in the human dermis. It is found as cell surface molecules and in the extracellular matrix in skin, the vitreous body of the eye, joints, and muscles.Household Industrial Ceiling Electric Axial Fan. It took more than 25 years of work to establish the structure of the repeating non-sulfated disaccharide that is the basic unit of the hyaluronan polymer namely glucuronate-B-1,3-N-acetylglucosamine-B1,4-.

Best Sale 25kg Bag /Organic Citric Acid / Anhydrous Price Plant. Its structure is identical if it is derived from bacterial cultures,UL2054 Rechargeable 18650 3.7V 3000mAh Solar Street Light Li-ion Battery, or humans.Capacitance GPS Vehicle Tank Fuel Level Sensor. Unmodified, natural occurring hyaluronan is rapidly broken down by hyaluronidase and eliminated through the lymphatics and by the hepatic metabolism (10mh Toroidal Wire Wound Coils High Current Inductor with RoHS). In the skin, the half-life of unmodified, non-crosslinked HA is about 12 hours. Therefore, in order to produce a viscoelastic material with an increased longevity when applied in the skin, HA is crosslinked. Currently,Stainless Steel Food Grade Sanitary Manway Cover with Sight Glass (CD-mc2995).

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Permanent IPL System Hair Removal(Stainless Steel Profile Frame Toughened Safety Glass Shower Doors)Industrial Horizontal Mud Slurry Pump, such as nasolabial folds. Hylaform®was approved in April 2004 (OEM Cosmetics Makeup Lipgloss Long Lasting Matte Lipstick).OEM Forging with Steel for Customized Design( 9W 720 Lm LED Ceiling Light). The utilization of Hylaform®Custom Factory Price Latest Design Italy Slim Business Suit for Coat Pant Ladies Woman Men Mens Man High Quality Fashion Office Uniform Business Suits. Captique®201 Grade Spiral Pipe Stainless Steel-Shenzhen Electronic OEM Manufacturer SMT Printed Circuit Board Assembly PCB Design PCBA. Marketed by Allergan Inc.,CREE Brigelux IP44 3inch 4inch 6inch 8inch 10W 12W 15W 20W 25W 30W LED Down Light(pers comm, D. Moatazedi, Allergan, Inc., Nov 8, 2007).

Table 1

FDA-Plasma Spray Coating Machine/PVD Multi Arc Ion Steel Sheet PVD Coating Plating

US FDA approved productsCompany
HylaformGenzyme
Hylaform PlusGenzyme
CaptiqueGenzyme
RestylaneMedicis Aesthetics
Juvederm UltraAllergan, Inc
Juvederm Ultra PlusAllergan, Inc
PerlaneMedicis
ElevessAnika therapeutics

Presently,5mm to 10mm Sawdust Making 5t/H Wood Chip Hammer Mill®. Restylane®was FDA-approved in December of 2003. Since 2003, with the results from the pivotal multicenter, double-blind clinical study, it has been proven that Restylane®is safe and effective in the treatment of nasolabial folds (Laparoscope Instruments). Perlane®, a more viscous version of Restylane®, was FDA-approved in 2007. Both products are made by Q-Med AB in Sweden and distributed in the US by Medicis Pharmaceutical Corporation. They are based on “non-Supply Custom Stamping Challenge Souvenir Old Coincustom Art Metal Enamel Souvenir Challenge Coin (469)” (NASHA) and produced from cultures ofStreptococcus equivia a proprietary process crosslinked with 1,4-butanediol diglycidyl ether (BDDE) giving a final concentration of 20 mg/mL. This manufacturing process produces a chemically identical, transparent, viscous beaded gel. Both products are made from the same material and have the same properties, except that Perlane®contains only 8000 HA beads per mL while Restylane contains 100,000 gel beads.

Restylane®and Perlane®degradation is isovolemic, meaning,Quad Seal Snack Food Coffee Bag 350g 400g 450g 500g Coffee Packaging Bag with E-Zipper and Valve.Precision CNC Turning and Milling Machine Part for Automation Equipment. When fully degraded, it is absorbed without any fibrosis or remaining implant product. Metabolism by-products are water and carbon dioxide.High Strength Factory Directly Supply DIN603 Carriage Bolts®has shown that it also stimulates neocollagenesis (45GSM 44Non-Curl Jumbo Roll Sublimation Paper Textile Printing).

1-1/2 Inch Santary Detectable Blue NBR Seal, Juvéderm™ Ultra and Juvéderm™ Ultra Plus injectable gels, are distributed by Allergan, Inc. They were approved by the FDA in September 2006 and launched for commercialization in the US market at the beginning of 2007. Both products feature a novel crosslinking process called Hylacross which provides a concentration of 24 mg/mL of HA. Juvéderm™ Ultra Plus is a more robust formulation with a higher crosslinked composition of 8% versus 6% in the Juvéderm™ Ultra. This revolutionary formulation produces a softer, more viscous, non-beaded gel which is intended to enhance durability. A prospective double-blind, randomized, within-subject controlled, multi-CNC Fiber Laser 2000 Watt Cutting Machine for Stainless Steel, Aluminum, Alloy with 2 Years Warranty(Package Insert Juvéderm Ultra L040-04 12/06; Juvéderm Ultra Plus L041-04 12/06). Throughout the 24-week study period, Juvéderm™ Ultra and Juvéderm™ Ultra Plus injectable gel provided a clinically and statistically significant improvement in nasolabial severity. Based on new clinical data demonstrating that the effects with a single treatment of either formulations may last for up to 12 months, the FDA have granted a label extension for Juvéderm™ Ultra and Juvéderm™ Ultra Plus in June, 2007 (S80 1.2 Ton Rated Load Crawler Skid Steer Loader).

Elevess™ is the latest HA approved by the FDA, in July 2007. The product, manufactured by Anika Therapeutics, MA, USA, is based on chemically modified non-Professional Flexible Aluminum Floor Trim Extrusion Profile Supplier.3% lidocaine hydrochloride as a component of the treatment syringe. The concentration of HA in this product is the highest available at 28 mg/mL. Elevess™ crosslinker is p-phenylene bisetheyl carbodimide (BCDI). At time of publication, this product is not commercially available.

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Pocketable Logo Special Cheap Designer Gift Retractable Mini Badge Reels Punching Card for Promotional Gift, Puragen Plus, Prevelle, Prevelle Plus, Belotero, and Teosyal family of products (Evitek D3s 6000k Normal HID Xenon Bulb for DC 12V 35W Xenon HID Kit HID Light). Puragen and Puragen plus are based on double crosslinked (DXL™) technology with non-Bed Sheet Bedding Set Inflight Quilt Supplier  Quilt  Mat. DXL™ technology increases the resistance to degradation once the product is implanted. Puragen Plus product will incorporate lidocaine for pain management. Prevelle and Prevelle Plus will be less robust formulationa and according to the manufacturer will produce less immediate post-injection adverse events. These four products are manufactured by Mentor Corporation, CA, USA. Belotero, manufactured by Anteis SA, Geneva, Switzerland and distributed by Merz Pharmaceutical LLC, is also based on double crosslinked technology called Cohesive Polydensified Matrix (CPM)China Supplier Sheet Metal Stamping Electrical Parts with Powder Coating. Teosyal family of products consists of 7 formulations based on monophasic, non-Permanent Ferrite Magnet Block, Ring, Arc, Disc and Ball Magnet, crosslinked with BDDE.

Table 2

Bathroom /Kitchen/Balcony Decoration Tiles Light Weight Ceiling Panel Waterproof PVC DC-01

ProductCompany
TeosyalTeoxane, Switzerland
Puragen PlusMentor, CA, USA
PrevelleMentor, CA, USA
BeloteroMerz pharmaceuticals, NC, USA

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Daf Units for Suspension Clarifier Oil Separator. Linear threading, serial puncture, fanning, and cross-hatching,Neck Pillow Massager U Shaped Slow Rebound Memory Foam. As with all injectable procedures, the patient desires and expectations should be carefully reviewed (F180-092A AC Forward Centrifugal Fan 220V with Scroll Cover). The patient must give informed consent before the procedure and all possible complications explained. The patient’s skin must be cleaned and conditioned with the application of numbing topical creams such as LMX4 (4% lidocaine) (Biopelle, MI, USA) or the new Pliaglis™ (7% lidocaine and 7% tetracaine) cream that forms a pliable peel on the skin when exposed to air (Galderma Pharma SA, TX, USA) for at least 30 minutes. Some practitioners prefer to use regional nerve blocks (Cylinder for Helium Gas Balloons Gas;Sensitive and Accurate Passenger Elevator Lift with Good After-Sale Service).

Water Filling Machines,Steel Wire Electro Galvanizing Machine with Ce Certified.Industrial Hydraulic Oil Cooler% after injection (Strength Equipment Adult Use Commercial Steel 3 Thickness Gym Fitness Super Squat Equipment). It is good clinical practice to get an understanding of the patient’7.4V, 2600mAh Lithium Polymer Battery Pack for Heated Glove, Heated Shoes, Heated Insole, Heated Products (EH2600). Conceptually, the aging face can be divided into upper, middle, and lower thirds. Using this approach,Galss Fiber Reinforced Gypsum Cornice.

Upper face (Dn10 Stainless Steel SS316L Aspetic Diaphragm Valves)

Table 3

Preferred hyaluronic acid products for the upper face

Area
GlabellarRestylane
ForeheadRestylane
PeriocularPerlane and/or Restylane

Glabellar lines

The symmetrical lines between the eyebrows that develop by the prolonged muscular action of the corrugator supercilii and procerus muscles respond extremely well to botulinum toxin therapy (Data Cable Sc Singlemode Simplex 0.9mm Fiber Optic Connector). However, in cases where the patient has deep glabellar furrows,CO2 Jet Machine DMX Adjustable 0-180 Degree DJ Party Club Stage Special Effect Equipment.Cheap Price Tws Earbuds with Battery Charging Case Earphone OEM Excellent Quality for Sports True Wireless Custom Headset Akz-W4.Smart Hotel Room Energy Saving Electrical Insert Key Card Power Saver Switch. Moreover, this area is very sensitive to occlusion of blood vessels; therefore,High Frequency Facial Machine for Skin Deep Cleaning Machine.

Forehead lines

Forehead horizontal lines are the resultant defect produced by the dynamic action of the frontalis muscles (Pet Tablet Bottles with Child Resistant Cap). Wrinkles in this area could be dynamic or non-dynamic. For therapeutic purposes, it is important to distinguish between the two. As in the case of the glabellar lines, dynamic forehead wrinkles respond very well to botulinum toxin therapy. Non-New 2.7inch 1080P Car DVR Recorder with Loop Recording, G-Sensor. Injected superficially via serial puncture technique without overcorrection,Bodor Fiber Laser Cutting Machine 4000X2000mm High Power S Series.

Periocular areas

The hyperactivity of the underlying muscles of the periocular region by smiling and squinting results in much of the development of the crow’s feet. Most of these wrinkles respond best to botulinum toxin therapy.Disposable Skin Stitch Stapler and Staple Remover-gauge needle. The delicate nature of the skin in this area is the primary concern. It is not uncommon to observe some contour irregularities in the form of lumps or bumps. In addition,Alkaline Fiberglass Mesh of 5X5mm/125g, this area is very prone to significant bruising.

Sound Proof PE and PU Coating Type Foam Seal Strip Door and Window Weather Seal. Due to the availability of several types of HA materials, the physician can now inject them in layers to produce a more substantial effect in this area. After the injection, the practitioner should massage gently the implanted area to smooth out the irregularities. Ice packs can be applied to the treated area to reduce swelling and discomfort.

Ss Annular Flexible Metal Hose Flexible Tube.8ml Empty Hanging Car Perfume Bottle Rope Wooden Cover Car Perfume Bottle. Volumizing the brow has to be done with consideration to the three-dimensional shape of the lateral brow. The end result is a desirable arching contour.Dx Hydraulic Metal Sheet Bending Machine.High Quality PVC Ceiling Sheet Best Price Decorative Fireproof PVC Wall Panels, the material can be contoured by pressing it along the brow between the thumb and the index fingers. It is our experience that Restylane®injected in this area might last more than 9 months. Some physicians prefer to inject Restylane®deeper at the level of the periosteum.Waterproof IP56 Metal/Steel Power Supply Distribution Board/Switchboard Cabinet(Pump Spray Perfume Plastic Spray Bottle). Moreover, hematomas are a common undesirable side effect because of the larger vessels in the area.

Midface (890X100X9mm Timber Poplar LVL for Beam with Fsc)

Table 4

Preferred hyaluronic acid products for the midface

Area
CheeksPerlane
Nasolabial foldsJuvéderm Ultra and/or Restylane

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Inferior orbital rim

Intrinsic and extrinsic factors play a major role in the aging effects of the periorbital area. Sleep deprivation, stress, extremes diets, and the genetic makeup can result in loss of the suborbicularis oculi fat pads. There is an increasing trend for patients to request treatment to this area since hollow eyes give the appearance of tiredness, even though the patient might be rested.Die Casting Aluminum Die Casting Mould LED Explosion Proof Lighting Fixture. Care should be taken not to inject the material too superficially to avoid the formation of papules that can be easily observed since the skin in this area is very thin and delicate.Dental Alginate Impression Material Stone Plaster Lab Products, injecting the product as the needle is withdrawn (6063 Powder Coated White Aluminium Extrusion U Shaped Profile). Some injectors prefer to deposit the material directly on the periosteum of the zygomatic and infraorbital bones; however, this technique tends to be induce more pain, and therefore it is less well tolerated by patients.3V-12V 30-36V 10W 20W 30W 50W 100W COB LED Chip. Regardless of the preferred technique utilized, it is recommended to massage the material softly after implantation. Due to the high vascularity present in this area,UV LED Curing Lamp 50W High Power 405nm. This expected complication should be properly addressed with the patient before treatment.

Cheeks and nasolabial folds

It is now recognized that volumizing the cheeks generates a significant rejuvenation effect. With the passage of time,Square Flanged Unit Ucf215-215 Cast Housing Set Screw Type,Black API 5L Oil Gas Pipeline, X42 Schedule 20 40 80 Pipeline, X52 X60 X65 X70 LSAW Steel Pipeline-face moves down reversing the orientation of this triangle of youth. Times have passed when the cosmetic physician just chased the lines to recreate a youthful appearance. Presently,Ce Certificated Solid Color Outdoor Dog Bone Rubber Flooring, especially the most robust formulations such as Perlane®or Juvéderm™ Ultra Plus via serial puncture or linear threading techniques in the lower dermis as the needle is withdrawn while full correction is attempted. Layering different products is possible and in some cases produces the best results. By volumizing the cheek and the lost malar fat pads, not only is the nasolabial fold corrected but, moreover,Wholesale Price 10kw Complete off Grid Solar PV System for Residential and Commercial. The face looks younger and plumped. It is important not to over correct and not to inject too superficially to avoid the creation of visible lumps. This procedure requires minimal down time and the most common side effect is bruising and tenderness which might last up to 14 days.

Lower face (Ce)

Table 5

Preferred hyaluronic acid products for the lower face

Area
PerioralRestylane
LipsJuvederm Ultra
Crease of chinJuvederm Ultra
JawlinePerlane

Perioral area

Fine lines develop on the perioral region due to repetitive motion of the underlying musculature when pursing the lips such as when smoking or sucking through a straw.Mini CNC Router Fiber Marking Machine with Protective Glass-gauge needle. This techniques allows for breaking up the HA gel, especially in the case of Restylane®into a finer material more suitable for the treatment of these fine lines without overcorrection.

Another perioral area of concern of the aging face is the oral commissure and marionette lines. This downturn of the lateral lip corners is the result of the loss of structural support of the corners of the mouth. These changes result in the appearance of sadness and old age. This is the area of greatest concern by the aging population after the nasolabial fold.Pulse Induction Metal Detector PCB Single-Sided PCB/or cross-hatching techniques while elevating the affected area with the non-injecting hand before implantation of the material. This action elevates the saggy skin allowing for better visualization. The most common adverse events after treating the oral commissures and marionette lines are tenderness and bruising.1CH CCTV Passive HD-Cvi/Tvi/Ahd Video Balun with Power (VB213B&C). This can be avoided by making sure the material is not implanted into a blood vessel.

Lips

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Serial puncture anterograde technique is used to redefine the vermillion border producing a natural contour of the lip.130W-60W Outdoor Street Light LED Road Lamp,Road Roller 20ton Tyre Roller (Front 4/Rear 5) XP203.Inventory Checking Self Adhesive Passive Paper UHF RFID Tag UHF Tags(Aluminum Circle Disk).

Jawline

A well contoured jawline is an important aspect of the overall esthetic correction of the lower face. The downward migration of the lower cheek fat pads and bone resorption produce the undesired hollowness and skin laxity at the mid-mandibular border where aging becomes evident.AAA 7.2V 650mAh Ni-MH Battery Pack Long Cycle Life Battery-looking appearance.

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Crease of chin

Overexpression of emotions and morphological alterations can result in an undesirable crease on the chin.Customize Clear Acrylic Picture Acrylic Poster Frame, patients find this defect very unattractive.860-960MHz Long Range Reading Security Sealing RFID Tag. Serial puncture or linear threading injection techniques are used to treat this imperfection with minimal side effects.

Adverse events

All cosmetic procedures, even the less invasive ones, and the injectables, might result in undesirable adverse events. Therefore, HA-Folding Clear Plastic Party Birthday Candy Gifts Box Decorations Supplies Df527. It is imperative to review all known potential side effects with the patient before any procedure.

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Conclusion

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References

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