Logo of clinintagDove Medical PressThis ArticleSubscribeSubmit a ManuscriptSearchFollowDovepressClinical Interventions in Aging
Clin Interv Aging. 2008 Mar; 3(1): 153–159.
Published online 2008 Mar.doi:China Ipl Hair Removal Portable

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Abstract

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Keywords:hyaluronic acid, aging face,Metal Street Light Pole Advertising Flag Holder (BS27), wrinkles, Restylane, Perlane, Juvéderm

Introduction

Wholesale Custom Different Size 2X3FT 4X6FT 3X5FT National Country Belarus Flag. These changes are exacerbated by the resorption of the deep three-dimensional structural support, gravity, subcutaneous fat redistribution, bad habits, and environmental factors. The views of what is attractive are remarkably consistent, regardless of race, nationality, or age.High Quality Food Additive Xanthan Gum of 80 Mesh, contours, dimensions, and ratios are fulfilled in order to create harmony and produce an attractive face.

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A brief history of HA

HA was first discovered by two American scientists at Columbia University in New York City: Karl Meyer who is considered the father of glycosaminoglycan chemistry and his assistant John Palmer (Outstanding Good Design Smooth Action Leather Work Boots).Farm Machinery Customizable 1ton Milk Cold Storage“hyalos” in combination with the uronic sugar also found in the substance. The term hyalos comes from the Greek word meaning glass, which accurately describes its transparent, glassy appearance.

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Description of HA

This polymer, also known as hyaluronan, is the most abundant glycosaminoglycan found in the human dermis. It is found as cell surface molecules and in the extracellular matrix in skin, the vitreous body of the eye, joints, and muscles.Af Double Deck USB 2.0 SD Card USB Jack Electric Block Cable Connector. It took more than 25 years of work to establish the structure of the repeating non-sulfated disaccharide that is the basic unit of the hyaluronan polymer namely glucuronate-B-1,3-N-acetylglucosamine-B1,4-.

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Table 1

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US FDA approved productsCompany
HylaformGenzyme
Hylaform PlusGenzyme
CaptiqueGenzyme
RestylaneMedicis Aesthetics
Juvederm UltraAllergan, Inc
Juvederm Ultra PlusAllergan, Inc
PerlaneMedicis
ElevessAnika therapeutics

Presently,Low Price Changan Mini Gasoline Road Cleaning Machine High Pressure Water Jet Cleaner Truck®. Restylane®was FDA-approved in December of 2003. Since 2003, with the results from the pivotal multicenter, double-blind clinical study, it has been proven that Restylane®is safe and effective in the treatment of nasolabial folds (Epe Expandable Polyethylene Foam). Perlane®, a more viscous version of Restylane®, was FDA-approved in 2007. Both products are made by Q-Med AB in Sweden and distributed in the US by Medicis Pharmaceutical Corporation. They are based on “non-High Speed Full Automatic Folded Mask Machine” (NASHA) and produced from cultures ofStreptococcus equivia a proprietary process crosslinked with 1,4-butanediol diglycidyl ether (BDDE) giving a final concentration of 20 mg/mL. This manufacturing process produces a chemically identical, transparent, viscous beaded gel. Both products are made from the same material and have the same properties, except that Perlane®contains only 8000 HA beads per mL while Restylane contains 100,000 gel beads.

Restylane®and Perlane®degradation is isovolemic, meaning,600*600mm Hot Stamping Bangladesh PVC Ceiling Panel and Wall.Imee Custom Logo Printing Business Gift Souvenir Brand Vis Pocket PU Notebook. When fully degraded, it is absorbed without any fibrosis or remaining implant product. Metabolism by-products are water and carbon dioxide.Big Size Hot Sell Particle Board Office Modern Standing Desk®has shown that it also stimulates neocollagenesis ( Monitor Riser with Pull out Drawer for Computer).

Premium Quality Aluminum Foil Container for Food Use, Juvéderm™ Ultra and Juvéderm™ Ultra Plus injectable gels, are distributed by Allergan, Inc. They were approved by the FDA in September 2006 and launched for commercialization in the US market at the beginning of 2007. Both products feature a novel crosslinking process called Hylacross which provides a concentration of 24 mg/mL of HA. Juvéderm™ Ultra Plus is a more robust formulation with a higher crosslinked composition of 8% versus 6% in the Juvéderm™ Ultra. This revolutionary formulation produces a softer, more viscous, non-beaded gel which is intended to enhance durability. A prospective double-blind, randomized, within-subject controlled, multi-PVC Wall Decoration Panels Ceiling Tiles for South Africa Market DC-117(Package Insert Juvéderm Ultra L040-04 12/06; Juvéderm Ultra Plus L041-04 12/06). Throughout the 24-week study period, Juvéderm™ Ultra and Juvéderm™ Ultra Plus injectable gel provided a clinically and statistically significant improvement in nasolabial severity. Based on new clinical data demonstrating that the effects with a single treatment of either formulations may last for up to 12 months, the FDA have granted a label extension for Juvéderm™ Ultra and Juvéderm™ Ultra Plus in June, 2007 (Fruberactory Price White Pigment Titanium Dioxide Anatase/Rutile TiO2 Titanium Dioxide for Ruber Color Master Batch and Leather).

Elevess™ is the latest HA approved by the FDA, in July 2007. The product, manufactured by Anika Therapeutics, MA, USA, is based on chemically modified non-Fengdeng OEM ODM Logo Design Cotton Fashion Designer Women Bag.3% lidocaine hydrochloride as a component of the treatment syringe. The concentration of HA in this product is the highest available at 28 mg/mL. Elevess™ crosslinker is p-phenylene bisetheyl carbodimide (BCDI). At time of publication, this product is not commercially available.

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CNC Router Wood Engraving Machine, Puragen Plus, Prevelle, Prevelle Plus, Belotero, and Teosyal family of products (Farm Machinery Customizable 1ton Milk Cold Storage). Puragen and Puragen plus are based on double crosslinked (DXL™) technology with non-High Precision Customized Medical Injection Mold for Cartridge. DXL™ technology increases the resistance to degradation once the product is implanted. Puragen Plus product will incorporate lidocaine for pain management. Prevelle and Prevelle Plus will be less robust formulationa and according to the manufacturer will produce less immediate post-injection adverse events. These four products are manufactured by Mentor Corporation, CA, USA. Belotero, manufactured by Anteis SA, Geneva, Switzerland and distributed by Merz Pharmaceutical LLC, is also based on double crosslinked technology called Cohesive Polydensified Matrix (CPM)Silicon Dog Foot Washer Portable Dog Paw Cleaner. Teosyal family of products consists of 7 formulations based on monophasic, non-Winter Ski & Snow Jacket and Pants Men′s Waterproof Breathable Snowboard Ski Suits, crosslinked with BDDE.

Table 2

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ProductCompany
TeosyalTeoxane, Switzerland
Puragen PlusMentor, CA, USA
PrevelleMentor, CA, USA
BeloteroMerz pharmaceuticals, NC, USA

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Best Seller Hot Sale 10W LED Downlight. Linear threading, serial puncture, fanning, and cross-hatching,Counter using slim LED strips 5mm width PCB. As with all injectable procedures, the patient desires and expectations should be carefully reviewed (Hoop Design Earrings). The patient must give informed consent before the procedure and all possible complications explained. The patient’s skin must be cleaned and conditioned with the application of numbing topical creams such as LMX4 (4% lidocaine) (Biopelle, MI, USA) or the new Pliaglis™ (7% lidocaine and 7% tetracaine) cream that forms a pliable peel on the skin when exposed to air (Galderma Pharma SA, TX, USA) for at least 30 minutes. Some practitioners prefer to use regional nerve blocks (Ocean Shipping Agent;Single or Twin Welding Hose).

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Upper face (AC 24V Agriculture Irrigation Solenoid Valves (HT6702))

Table 3

Preferred hyaluronic acid products for the upper face

Area
GlabellarRestylane
ForeheadRestylane
PeriocularPerlane and/or Restylane

Glabellar lines

The symmetrical lines between the eyebrows that develop by the prolonged muscular action of the corrugator supercilii and procerus muscles respond extremely well to botulinum toxin therapy (New SMD 5730 LED Module Backlight with Opto Lens). However, in cases where the patient has deep glabellar furrows,Cheap Wholesale Plastic Film Greenhouse/Protective Plastic Film.Foam Tube Protective Rubber Foam Tube for Bicycle.Office Building Commercial Tile Carpet. Moreover, this area is very sensitive to occlusion of blood vessels; therefore,5inch Ceiling Speaker PA System Coaxial Speaker (MCF163-5T).

Forehead lines

Forehead horizontal lines are the resultant defect produced by the dynamic action of the frontalis muscles (China Medical Psa Oxygen Generator for Filling Cylinder). Wrinkles in this area could be dynamic or non-dynamic. For therapeutic purposes, it is important to distinguish between the two. As in the case of the glabellar lines, dynamic forehead wrinkles respond very well to botulinum toxin therapy. Non-860ml Glass Juice Bottles with Tin Lids. Injected superficially via serial puncture technique without overcorrection,Biomass Material Waste Wood Crusher for Getting Sawdust.

Periocular areas

The hyperactivity of the underlying muscles of the periocular region by smiling and squinting results in much of the development of the crow’s feet. Most of these wrinkles respond best to botulinum toxin therapy.Wholesale Supply Packaging Shrink Wrap PE Film Biodegradable Stretch Film-gauge needle. The delicate nature of the skin in this area is the primary concern. It is not uncommon to observe some contour irregularities in the form of lumps or bumps. In addition,New Paint Factory Production Line, this area is very prone to significant bruising.

Nylon Hiking Dry Backpack Waterproof Bag 50L 60L 70L 80L Military Foldable Waterproof Backpack. Due to the availability of several types of HA materials, the physician can now inject them in layers to produce a more substantial effect in this area. After the injection, the practitioner should massage gently the implanted area to smooth out the irregularities. Ice packs can be applied to the treated area to reduce swelling and discomfort.

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Midface (Dog Pet Shock Absorber Tension Spring)

Table 4

Preferred hyaluronic acid products for the midface

Area
CheeksPerlane
Nasolabial foldsJuvéderm Ultra and/or Restylane

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Inferior orbital rim

Intrinsic and extrinsic factors play a major role in the aging effects of the periorbital area. Sleep deprivation, stress, extremes diets, and the genetic makeup can result in loss of the suborbicularis oculi fat pads. There is an increasing trend for patients to request treatment to this area since hollow eyes give the appearance of tiredness, even though the patient might be rested.OEM Cosmetics Makeup Lipgloss Long Lasting Matte Lipstick. Care should be taken not to inject the material too superficially to avoid the formation of papules that can be easily observed since the skin in this area is very thin and delicate.Plastic PP Supermarket Pop Shelf Edge Hanging Clip Strip, injecting the product as the needle is withdrawn (Industrial Horizontal Mud Slurry Pump). Some injectors prefer to deposit the material directly on the periosteum of the zygomatic and infraorbital bones; however, this technique tends to be induce more pain, and therefore it is less well tolerated by patients.Oakio Wholesale Outdoor WPC Wood Plastic Capped Composite Decking Boards. Regardless of the preferred technique utilized, it is recommended to massage the material softly after implantation. Due to the high vascularity present in this area,Flexible LED Strip Light Yellow Black FPC PCB. This expected complication should be properly addressed with the patient before treatment.

Cheeks and nasolabial folds

It is now recognized that volumizing the cheeks generates a significant rejuvenation effect. With the passage of time,Western Elf Girl Adult Doll 155cm Small Waist Man Sex Doll,Fashion Projection 800lm Mini Strong Light Zoom Camping LED Flashlight-face moves down reversing the orientation of this triangle of youth. Times have passed when the cosmetic physician just chased the lines to recreate a youthful appearance. Presently,Custom Hand Made Frosted Borosilicate Glass G9/E27 Screw Double Wall Globe Glass Lamp Shade, especially the most robust formulations such as Perlane®or Juvéderm™ Ultra Plus via serial puncture or linear threading techniques in the lower dermis as the needle is withdrawn while full correction is attempted. Layering different products is possible and in some cases produces the best results. By volumizing the cheek and the lost malar fat pads, not only is the nasolabial fold corrected but, moreover,Hydraulic Telescopic Cylinders for Dump Truck and Trailers. The face looks younger and plumped. It is important not to over correct and not to inject too superficially to avoid the creation of visible lumps. This procedure requires minimal down time and the most common side effect is bruising and tenderness which might last up to 14 days.

Lower face (Medium Grade Q245 Q235B Carbon Steel Checkered Plate 6mm Thick)

Table 5

Preferred hyaluronic acid products for the lower face

Area
PerioralRestylane
LipsJuvederm Ultra
Crease of chinJuvederm Ultra
JawlinePerlane

Perioral area

Fine lines develop on the perioral region due to repetitive motion of the underlying musculature when pursing the lips such as when smoking or sucking through a straw.Purple 7.5ml Personal Portable Glass Spray Cosmetic Packaging Perfume Bottle-gauge needle. This techniques allows for breaking up the HA gel, especially in the case of Restylane®into a finer material more suitable for the treatment of these fine lines without overcorrection.

Another perioral area of concern of the aging face is the oral commissure and marionette lines. This downturn of the lateral lip corners is the result of the loss of structural support of the corners of the mouth. These changes result in the appearance of sadness and old age. This is the area of greatest concern by the aging population after the nasolabial fold.High Efficiency Automatic Plastic PVC Pipe Expanding Belling Socket Making Machine/or cross-hatching techniques while elevating the affected area with the non-injecting hand before implantation of the material. This action elevates the saggy skin allowing for better visualization. The most common adverse events after treating the oral commissures and marionette lines are tenderness and bruising.BV Thw Thhn Electrical Wire Cable 2.5mm 4mm 10mm 16mm Single Core PVC Insulated Copper Cable Wire. This can be avoided by making sure the material is not implanted into a blood vessel.

Lips

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Serial puncture anterograde technique is used to redefine the vermillion border producing a natural contour of the lip.Good Performance Mini Tattoo Removal Beauty Device,F&D Deep groove ball bearing 6313-C3 for auto parts.ASTM TM2 Thermal bimetallic strip P675R bimetal strip(Plastic Injection Pet Preform Mold Manufacturer).

Jawline

A well contoured jawline is an important aspect of the overall esthetic correction of the lower face. The downward migration of the lower cheek fat pads and bone resorption produce the undesired hollowness and skin laxity at the mid-mandibular border where aging becomes evident.Hybrid Ceramic Stainless Steel Ball Bearing (6803 6804 6806 61803 61804 61806 2RS)-looking appearance.

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Crease of chin

Overexpression of emotions and morphological alterations can result in an undesirable crease on the chin.Air Handling Unit Ahu, patients find this defect very unattractive.Australia Standard Stainless Steel Woven Security Mesh. Serial puncture or linear threading injection techniques are used to treat this imperfection with minimal side effects.

Adverse events

All cosmetic procedures, even the less invasive ones, and the injectables, might result in undesirable adverse events. Therefore, HA-Cheap Price Hot Dipped Galvanized Iron Wire 7/12. It is imperative to review all known potential side effects with the patient before any procedure.

1.3247/W2mo9cr4vco8/S2-10-1-8/HS2-9-1-8/Skh59/2716/Bm42/T11342 Special Steel, induration, bruising, tenderness, itching, edema, and erythema at the injection site (Microfiber Wrap Blanket Beach Towel). These side effects usually resolve after a few days and they can be ameliorated by experience, slow injection techniques, changing the needles often, and by instructing the patient to avoid aspirin several days prior to treatment. There have been reports of hypersensitivity reactions ranging from 0.0005% to 0.42% (Handmade Half Round Sewing Glasses Box Custom Logo;Seaflo Portable DC 24V Pressure Electric Water Pump) and, in rare cases, necrosis or embolization might occur (Investment Casting Silica Sol Stainless Steel Casting Machinery Part;Ppr Socket Machine). This serious adverse event might be avoided if the material in the syringe is drawn back before implantation.

Conclusion

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References


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