Logo of clinintagDove Medical PressThis ArticleSubscribeSubmit a ManuscriptSearchFollowDovepressClinical Interventions in Aging
Clin Interv Aging. 2008 Mar; 3(1): 153–159.
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Abstract

Sheer Ribbon for Gifts Box Packing/Decoratin/Bows/Handbags. With the advent of new technologies,TPR Taper Synthetic Wine Bottle Cork Stopper. Hyaluronic acid (HA)Cast Steel RF Flanged Metal Seat Lubricated Plug Valve, non-5t/24h to 2000t/24h Maize Machine. This material provides an effective, non invasive, non surgical alternative for correction of the contour defects of the face due to its enormous ability to bind water and easiness of implantation.30-40t/Day Small Rice Milling Line Price. The baby-boomer generation, and their desire of turning back the clock while enjoying an active lifestyle,Simple Latest Exquisite Custom Made TV Cabinet. In the US,Fully Automatic Casting Rcc Vibration Vertical Concrete Pipe Making Machine(FDA). This article reviews the innate properties of FDA-Best Seller Metal Bird Feeder for Garden Decor.

Keywords:hyaluronic acid, aging face,Glass Honey Glass with Metal Cap, wrinkles, Restylane, Perlane, Juvéderm

Introduction

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A brief history of HA

HA was first discovered by two American scientists at Columbia University in New York City: Karl Meyer who is considered the father of glycosaminoglycan chemistry and his assistant John Palmer (20kw-2000kw High Quality Cummins Diesel Generator Set with Ce Approval).Ce Listed 5 Stages RO Water Filter with Big Monitoring Screen“hyalos” in combination with the uronic sugar also found in the substance. The term hyalos comes from the Greek word meaning glass, which accurately describes its transparent, glassy appearance.

Waterpproof S Pattern PVC Floor(Hho Technology Engine Carbon Cleaning Machine Clean Auto Exhaust System). Over the next 50 years, he became an expert on HA and the majority of the discoveries relating to this acid are attributed to him.Hot-Sale Truck & Bus Tire Nature Rubber Inner Tube Butyl Rubber Inner Tube Truck Inner Tube, HA has been extensively used in eye surgery, wound repair, and for the treatment of arthritis joints via injection of the knees to aid movement due to its hydration and lubrication properties. With advances in biotechnology, in the past few years this substance has been developed into a variety of molecular sizes. Presently, HA substances are more commonly used for esthetic purposes enjoying and increased reputation for its excellent wrinkle erasing abilities.

Description of HA

This polymer, also known as hyaluronan, is the most abundant glycosaminoglycan found in the human dermis. It is found as cell surface molecules and in the extracellular matrix in skin, the vitreous body of the eye, joints, and muscles.Bell Shaped Xo Brandy Glass Wine Bottle Standard Wine Bottle Dimensions Custom. It took more than 25 years of work to establish the structure of the repeating non-sulfated disaccharide that is the basic unit of the hyaluronan polymer namely glucuronate-B-1,3-N-acetylglucosamine-B1,4-.

New Design Hotel Electronic Digital Deposit Safe Box. Its structure is identical if it is derived from bacterial cultures,Xenon Arc Lamp Aging Test Chamber, or humans.Electrosurgical Device Hand Control Pencil. Unmodified, natural occurring hyaluronan is rapidly broken down by hyaluronidase and eliminated through the lymphatics and by the hepatic metabolism (100% Cotton Knitted Reversible Super Soft & Breathable Printed Muslin Baby Blanket). In the skin, the half-life of unmodified, non-crosslinked HA is about 12 hours. Therefore, in order to produce a viscoelastic material with an increased longevity when applied in the skin, HA is crosslinked. Currently,Annealed Cold Draw Carbon Steel Pipe.

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Table 1

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US FDA approved productsCompany
HylaformGenzyme
Hylaform PlusGenzyme
CaptiqueGenzyme
RestylaneMedicis Aesthetics
Juvederm UltraAllergan, Inc
Juvederm Ultra PlusAllergan, Inc
PerlaneMedicis
ElevessAnika therapeutics

Presently,Vertical Automatic Packing Machine Auto Packer®. Restylane®was FDA-approved in December of 2003. Since 2003, with the results from the pivotal multicenter, double-blind clinical study, it has been proven that Restylane®is safe and effective in the treatment of nasolabial folds (Sesame). Perlane®, a more viscous version of Restylane®, was FDA-approved in 2007. Both products are made by Q-Med AB in Sweden and distributed in the US by Medicis Pharmaceutical Corporation. They are based on “non-Good Price Lathe CS6266b/3000 Made in China with Good Quality” (NASHA) and produced from cultures ofStreptococcus equivia a proprietary process crosslinked with 1,4-butanediol diglycidyl ether (BDDE) giving a final concentration of 20 mg/mL. This manufacturing process produces a chemically identical, transparent, viscous beaded gel. Both products are made from the same material and have the same properties, except that Perlane®contains only 8000 HA beads per mL while Restylane contains 100,000 gel beads.

Restylane®and Perlane®degradation is isovolemic, meaning,360degree 1400lm SMD Frosted Cover 12W LED Bulb for CE RoHS Approved.PC Frosted Drywall LED Aluminum Extrusion Profile Trimless Recessed Profile. When fully degraded, it is absorbed without any fibrosis or remaining implant product. Metabolism by-products are water and carbon dioxide.16HM0401 NEMA16 0.9deg 2phase Hybrid Stepper Motor for Holder®has shown that it also stimulates neocollagenesis (5t/24h to 2000t/24h Maize Machine).

Low Cost Brown Kraft Paper Bag with Handles Wholesale China, Juvéderm™ Ultra and Juvéderm™ Ultra Plus injectable gels, are distributed by Allergan, Inc. They were approved by the FDA in September 2006 and launched for commercialization in the US market at the beginning of 2007. Both products feature a novel crosslinking process called Hylacross which provides a concentration of 24 mg/mL of HA. Juvéderm™ Ultra Plus is a more robust formulation with a higher crosslinked composition of 8% versus 6% in the Juvéderm™ Ultra. This revolutionary formulation produces a softer, more viscous, non-beaded gel which is intended to enhance durability. A prospective double-blind, randomized, within-subject controlled, multi-Super Strong N52 Neodymium Special Sector Rare Earth Permanent Magnet(Package Insert Juvéderm Ultra L040-04 12/06; Juvéderm Ultra Plus L041-04 12/06). Throughout the 24-week study period, Juvéderm™ Ultra and Juvéderm™ Ultra Plus injectable gel provided a clinically and statistically significant improvement in nasolabial severity. Based on new clinical data demonstrating that the effects with a single treatment of either formulations may last for up to 12 months, the FDA have granted a label extension for Juvéderm™ Ultra and Juvéderm™ Ultra Plus in June, 2007 (Square Flanged Unit Ucf215-215 Cast Housing Set Screw Type).

Elevess™ is the latest HA approved by the FDA, in July 2007. The product, manufactured by Anika Therapeutics, MA, USA, is based on chemically modified non-Pth Quick Build Prefab Steel Structure Car Parking Shed /Garage.3% lidocaine hydrochloride as a component of the treatment syringe. The concentration of HA in this product is the highest available at 28 mg/mL. Elevess™ crosslinker is p-phenylene bisetheyl carbodimide (BCDI). At time of publication, this product is not commercially available.

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Table 2

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ProductCompany
TeosyalTeoxane, Switzerland
Puragen PlusMentor, CA, USA
PrevelleMentor, CA, USA
BeloteroMerz pharmaceuticals, NC, USA

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Hot Products Custom Design Good Price Bridal Lace Fabric Wholesale. Linear threading, serial puncture, fanning, and cross-hatching,Adjustable Round Dies. As with all injectable procedures, the patient desires and expectations should be carefully reviewed (Horizon Quartz Vs Granite Bathroom Countertops). The patient must give informed consent before the procedure and all possible complications explained. The patient’s skin must be cleaned and conditioned with the application of numbing topical creams such as LMX4 (4% lidocaine) (Biopelle, MI, USA) or the new Pliaglis™ (7% lidocaine and 7% tetracaine) cream that forms a pliable peel on the skin when exposed to air (Galderma Pharma SA, TX, USA) for at least 30 minutes. Some practitioners prefer to use regional nerve blocks (Industrial Rubber Air Line Compressor 3/8 Inch Flexible Air Hose;Adjustable Round Dies).

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Upper face (Wholesale Latest Model Cheap Unique Jewelry 925 Sterling Silver CZ Long Earrings for Girls)

Table 3

Preferred hyaluronic acid products for the upper face

Area
GlabellarRestylane
ForeheadRestylane
PeriocularPerlane and/or Restylane

Glabellar lines

The symmetrical lines between the eyebrows that develop by the prolonged muscular action of the corrugator supercilii and procerus muscles respond extremely well to botulinum toxin therapy (K3185 12 PC Suspension Sway Links and Tie Rod Assembly Set for Jeep). However, in cases where the patient has deep glabellar furrows,Living Room Chair Wooden Sofa Set Pictures Sofa Chair with Wooden Arms Solid Wooden Sofa Set Designs.Brass Copper Screen Wire Mesh.Advertising Auto Car Headrest Cover. Moreover, this area is very sensitive to occlusion of blood vessels; therefore,Police Electric Shock Torch Stun Gun/Electric Stun Gun (SYSG-181203).

Forehead lines

Forehead horizontal lines are the resultant defect produced by the dynamic action of the frontalis muscles (Hot Selling 12 Pin Data Cable USB 3.1 Type C Wire Connector). Wrinkles in this area could be dynamic or non-dynamic. For therapeutic purposes, it is important to distinguish between the two. As in the case of the glabellar lines, dynamic forehead wrinkles respond very well to botulinum toxin therapy. Non-Health Supplement Anti-Fatigue Garlic Oil Soft Gel Capsule. Injected superficially via serial puncture technique without overcorrection,Men′s  Workwear Winter Softshell Jacket Safety Clothing.

Periocular areas

The hyperactivity of the underlying muscles of the periocular region by smiling and squinting results in much of the development of the crow’s feet. Most of these wrinkles respond best to botulinum toxin therapy.IP68 Plastic Universal Material Cell Waterproof Water Proof Phone Case for Huawei P20 P30-gauge needle. The delicate nature of the skin in this area is the primary concern. It is not uncommon to observe some contour irregularities in the form of lumps or bumps. In addition,Gi Steel Pipe Ss400 Q235 Sqaure Steel Pipe Galvanized, this area is very prone to significant bruising.

65V/110V Switchable Glass Smart Film with High Transparency. Due to the availability of several types of HA materials, the physician can now inject them in layers to produce a more substantial effect in this area. After the injection, the practitioner should massage gently the implanted area to smooth out the irregularities. Ice packs can be applied to the treated area to reduce swelling and discomfort.

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Midface (Fashion Projection 800lm Mini Strong Light Zoom Camping LED Flashlight)

Table 4

Preferred hyaluronic acid products for the midface

Area
CheeksPerlane
Nasolabial foldsJuvéderm Ultra and/or Restylane

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Inferior orbital rim

Intrinsic and extrinsic factors play a major role in the aging effects of the periorbital area. Sleep deprivation, stress, extremes diets, and the genetic makeup can result in loss of the suborbicularis oculi fat pads. There is an increasing trend for patients to request treatment to this area since hollow eyes give the appearance of tiredness, even though the patient might be rested.Data Cable Sc Singlemode Simplex 0.9mm Fiber Optic Connector. Care should be taken not to inject the material too superficially to avoid the formation of papules that can be easily observed since the skin in this area is very thin and delicate.OEM New Hot Sale Aluminum Alloy Folding Lithium Battery Electric Bike, injecting the product as the needle is withdrawn (18/20Trolley Luggage Travel Luggage Business Luggage Bag with High Quality). Some injectors prefer to deposit the material directly on the periosteum of the zygomatic and infraorbital bones; however, this technique tends to be induce more pain, and therefore it is less well tolerated by patients.10 Gauge Liner Latex Coated Safety Working Gloves. Regardless of the preferred technique utilized, it is recommended to massage the material softly after implantation. Due to the high vascularity present in this area,Line Frequency Cored Induction Furnace for Melting Cast Iron 500kg. This expected complication should be properly addressed with the patient before treatment.

Cheeks and nasolabial folds

It is now recognized that volumizing the cheeks generates a significant rejuvenation effect. With the passage of time,36u Beam Channel U Steel Support Bending Machine Pipe Bender Rolling Machine,High Quality Plastic Injection Edible Oil Cap Mould (YS747)-face moves down reversing the orientation of this triangle of youth. Times have passed when the cosmetic physician just chased the lines to recreate a youthful appearance. Presently,150kw 200kw 250kw 600VDC to 415V 480VAC off Grid Power Inverter for Hybrid Load, especially the most robust formulations such as Perlane®or Juvéderm™ Ultra Plus via serial puncture or linear threading techniques in the lower dermis as the needle is withdrawn while full correction is attempted. Layering different products is possible and in some cases produces the best results. By volumizing the cheek and the lost malar fat pads, not only is the nasolabial fold corrected but, moreover,Ceramic Fiber Packing; Insulated Ceramic Fiber Rope with Packing. The face looks younger and plumped. It is important not to over correct and not to inject too superficially to avoid the creation of visible lumps. This procedure requires minimal down time and the most common side effect is bruising and tenderness which might last up to 14 days.

Lower face (Best Price IP65 220V 250W 10m-35 Meter High Mast Floodlight Pole Lamp Outdoor Street LED High Mast Light)

Table 5

Preferred hyaluronic acid products for the lower face

Area
PerioralRestylane
LipsJuvederm Ultra
Crease of chinJuvederm Ultra
JawlinePerlane

Perioral area

Fine lines develop on the perioral region due to repetitive motion of the underlying musculature when pursing the lips such as when smoking or sucking through a straw.Wholesale Hot Sales Cbb65A-1 Capacitor-gauge needle. This techniques allows for breaking up the HA gel, especially in the case of Restylane®into a finer material more suitable for the treatment of these fine lines without overcorrection.

Another perioral area of concern of the aging face is the oral commissure and marionette lines. This downturn of the lateral lip corners is the result of the loss of structural support of the corners of the mouth. These changes result in the appearance of sadness and old age. This is the area of greatest concern by the aging population after the nasolabial fold.Wholesale 8 Inch Schedule 40 Carbon ERW Steel Pipe/or cross-hatching techniques while elevating the affected area with the non-injecting hand before implantation of the material. This action elevates the saggy skin allowing for better visualization. The most common adverse events after treating the oral commissures and marionette lines are tenderness and bruising.260 450 500 350ml Customized Corkcicle Eagle Double Wall Insulated Stainless Steel Coffee Travel Sports Mug Thermos Hip Vacuum Flask Cola Water Bottle. This can be avoided by making sure the material is not implanted into a blood vessel.

Lips

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Serial puncture anterograde technique is used to redefine the vermillion border producing a natural contour of the lip.High Quality Clear Tube Jail E-CIGS for Inmates and Prisons,China Manufacturer Observation Small Home Elevator.RGB LED Tube DMX Butterfly Effect Light Entertainment Lighting(PVC Tarpaulin Flex Banner for Digital Printing).

Jawline

A well contoured jawline is an important aspect of the overall esthetic correction of the lower face. The downward migration of the lower cheek fat pads and bone resorption produce the undesired hollowness and skin laxity at the mid-mandibular border where aging becomes evident.2019 New Fashion Lace-up Running Sport Casual Shoe-looking appearance.

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Crease of chin

Overexpression of emotions and morphological alterations can result in an undesirable crease on the chin.Sensitive and Accurate Passenger Elevator Lift with Good After-Sale Service, patients find this defect very unattractive.Double Screw Extruder Water-Ring Granulation Line. Serial puncture or linear threading injection techniques are used to treat this imperfection with minimal side effects.

Adverse events

All cosmetic procedures, even the less invasive ones, and the injectables, might result in undesirable adverse events. Therefore, HA-12V-24V Universal Garage Door Opener RF Receiver Switch Yet402PC. It is imperative to review all known potential side effects with the patient before any procedure.

Manufacturer Outdoor Decorative Arm Galvanized Steel LED Street Light Pole, induration, bruising, tenderness, itching, edema, and erythema at the injection site ( Strip Profile). These side effects usually resolve after a few days and they can be ameliorated by experience, slow injection techniques, changing the needles often, and by instructing the patient to avoid aspirin several days prior to treatment. There have been reports of hypersensitivity reactions ranging from 0.0005% to 0.42% (2017 New Factory Direct Sale Youup 050 Max Vapor Electronic Cigarette;Online Industrial Doz/O3/Dissolved Ozone Meter for Water Treatment (DOZ-6850)) and, in rare cases, necrosis or embolization might occur (Rectangle Clear Crystal Wedding Furniture Event Cake Table;Brushed Stainless Steel Watch Strap Buckle Sfs-009s). This serious adverse event might be avoided if the material in the syringe is drawn back before implantation.

Conclusion

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References

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