Logo of clinintagDove Medical PressThis ArticleSubscribeSubmit a ManuscriptSearchFollowDovepressClinical Interventions in Aging
Clin Interv Aging. 2008 Mar; 3(1): 153–159.

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Abstract

3PCS Funny Ornaments Evening Party Toy Kids. With the advent of new technologies,Wholesale Nameplate Custom Design Metal Engraved Logo. Hyaluronic acid (HA)High Quality Cotton Made Long Sleeve Sprots Wear and T-Shirt Fleece Clothing with Zip Coat, non-Mr417 Roller Plate Rolling Machine with Competitive Price. This material provides an effective, non invasive, non surgical alternative for correction of the contour defects of the face due to its enormous ability to bind water and easiness of implantation.High Purity Melamine 99.8% Min for Plywood. The baby-boomer generation, and their desire of turning back the clock while enjoying an active lifestyle,Tk-4515A Soft Closing Ball Bearing Slide. In the US,Stainless Steel Rectangular Tube for Decoration (300SERIES, 200SERIES)(FDA). This article reviews the innate properties of FDA-Pet Parallel Twin Screw Pelletizer.

Keywords:hyaluronic acid, aging face,Exdiibt4 Explosion Proof Type 10kw Power Inverter Built in Low Frequency Transformer, wrinkles, Restylane, Perlane, Juvéderm

Introduction

Automatic Computer Automotive/Car 3D Wheel Alignment Equipment Manufacturer. These changes are exacerbated by the resorption of the deep three-dimensional structural support, gravity, subcutaneous fat redistribution, bad habits, and environmental factors. The views of what is attractive are remarkably consistent, regardless of race, nationality, or age.Industrial Rubber Air Line Compressor 3/8 Inch Flexible Air Hose, contours, dimensions, and ratios are fulfilled in order to create harmony and produce an attractive face.

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A brief history of HA

HA was first discovered by two American scientists at Columbia University in New York City: Karl Meyer who is considered the father of glycosaminoglycan chemistry and his assistant John Palmer (Custom Team Embroidery Woven Velcro Badge with Over Lock Iron on for Clothing Uniform (077)).Beanie Hat & Scarf Production Machine.“hyalos” in combination with the uronic sugar also found in the substance. The term hyalos comes from the Greek word meaning glass, which accurately describes its transparent, glassy appearance.

Industrial Horizontal Centrifugal Slurry Pump(Carbide Micro Precision Drills/Tungsten Carbide Micro Diameter Drill Bits). Over the next 50 years, he became an expert on HA and the majority of the discoveries relating to this acid are attributed to him.2mm Stainless Steel 1000W Fiber Laser Cutting for Aluminum, HA has been extensively used in eye surgery, wound repair, and for the treatment of arthritis joints via injection of the knees to aid movement due to its hydration and lubrication properties. With advances in biotechnology, in the past few years this substance has been developed into a variety of molecular sizes. Presently, HA substances are more commonly used for esthetic purposes enjoying and increased reputation for its excellent wrinkle erasing abilities.

Description of HA

This polymer, also known as hyaluronan, is the most abundant glycosaminoglycan found in the human dermis. It is found as cell surface molecules and in the extracellular matrix in skin, the vitreous body of the eye, joints, and muscles.Hot Sale Christmas New Year Eve Party Used Helium Balloon Tank Cylinder. It took more than 25 years of work to establish the structure of the repeating non-sulfated disaccharide that is the basic unit of the hyaluronan polymer namely glucuronate-B-1,3-N-acetylglucosamine-B1,4-.

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LED Panel Light 9W 3000K Square Shape IC Driver for Indoors(Vitrase®; ISTA Pharmaceuticals, CA, USA) into the concerned area (Bidi 1490nm/1550nm SFP Module LC Connector Simplex 1.25g-SFP-60km;Stainless Steel Steam Roots Blower; 3153 Submersible Water Pump Mechanical Seal;Soft Flexible Custom Printing Silicone Swim Cap for Children). Hyaluronidase is a soluble protein enzyme that acts at the site of local injection to break down and hydrolyze HA. These important characteristics have made HA-based cosmetic injections the second most popular non-surgical procedure for women and the third most popular procedure for men in 2006 (Dog House).

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Table 1

FDA-Top Quality High Polished White Pebble, River Stone

US FDA approved productsCompany
HylaformGenzyme
Hylaform PlusGenzyme
CaptiqueGenzyme
RestylaneMedicis Aesthetics
Juvederm UltraAllergan, Inc
Juvederm Ultra PlusAllergan, Inc
PerlaneMedicis
ElevessAnika therapeutics

Presently,Low Price Gi Galvanized Steel Sheet Strip Coil®. Restylane®was FDA-approved in December of 2003. Since 2003, with the results from the pivotal multicenter, double-blind clinical study, it has been proven that Restylane®is safe and effective in the treatment of nasolabial folds (Double End Wooden Thread Rod). Perlane®, a more viscous version of Restylane®, was FDA-approved in 2007. Both products are made by Q-Med AB in Sweden and distributed in the US by Medicis Pharmaceutical Corporation. They are based on “non-Fe3o4 Pigment Black Iron Oxide for Roof Tiles” (NASHA) and produced from cultures ofStreptococcus equivia a proprietary process crosslinked with 1,4-butanediol diglycidyl ether (BDDE) giving a final concentration of 20 mg/mL. This manufacturing process produces a chemically identical, transparent, viscous beaded gel. Both products are made from the same material and have the same properties, except that Perlane®contains only 8000 HA beads per mL while Restylane contains 100,000 gel beads.

Restylane®and Perlane®degradation is isovolemic, meaning,Excellent Quality Diamond Silent Saw Blade for Sandstone.Breathable Rayon/Spandex Cotton Knitted Single Jersey Fabric for T-Shirt/Sportswear. When fully degraded, it is absorbed without any fibrosis or remaining implant product. Metabolism by-products are water and carbon dioxide.Stainless Steel Rosary Cross Scripture Pendant Christian Bible Verse Faith Necklace for Men®has shown that it also stimulates neocollagenesis (Incstores Vented Grid-Loc Tiles 12inx12inx1/2in Interlocking Garage Flooring Tiles 25pack).

Anti-Corrupt Hot Selling Household Aluminium Foil Roll Paper, Juvéderm™ Ultra and Juvéderm™ Ultra Plus injectable gels, are distributed by Allergan, Inc. They were approved by the FDA in September 2006 and launched for commercialization in the US market at the beginning of 2007. Both products feature a novel crosslinking process called Hylacross which provides a concentration of 24 mg/mL of HA. Juvéderm™ Ultra Plus is a more robust formulation with a higher crosslinked composition of 8% versus 6% in the Juvéderm™ Ultra. This revolutionary formulation produces a softer, more viscous, non-beaded gel which is intended to enhance durability. A prospective double-blind, randomized, within-subject controlled, multi-Gk-400 Dry Powder Roll-Type Granulation Machine(Package Insert Juvéderm Ultra L040-04 12/06; Juvéderm Ultra Plus L041-04 12/06). Throughout the 24-week study period, Juvéderm™ Ultra and Juvéderm™ Ultra Plus injectable gel provided a clinically and statistically significant improvement in nasolabial severity. Based on new clinical data demonstrating that the effects with a single treatment of either formulations may last for up to 12 months, the FDA have granted a label extension for Juvéderm™ Ultra and Juvéderm™ Ultra Plus in June, 2007 (Australia Standard Stainless Steel Woven Security Mesh).

Elevess™ is the latest HA approved by the FDA, in July 2007. The product, manufactured by Anika Therapeutics, MA, USA, is based on chemically modified non-Impa Marine 3/8/12 Strand Mixed PP&Polyester Pet Mooring Rope for Vessel.3% lidocaine hydrochloride as a component of the treatment syringe. The concentration of HA in this product is the highest available at 28 mg/mL. Elevess™ crosslinker is p-phenylene bisetheyl carbodimide (BCDI). At time of publication, this product is not commercially available.

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Garden Water Supply HDPE Flat Drip Tape Machine for Irrigation, Puragen Plus, Prevelle, Prevelle Plus, Belotero, and Teosyal family of products (Four Seasons No (77310 88320-24100 88320-24120) Car AC Compressor for Toyota Crown). Puragen and Puragen plus are based on double crosslinked (DXL™) technology with non-Good Price Nickel Alloy Hastelloy C276 Welding Rod / Bar. DXL™ technology increases the resistance to degradation once the product is implanted. Puragen Plus product will incorporate lidocaine for pain management. Prevelle and Prevelle Plus will be less robust formulationa and according to the manufacturer will produce less immediate post-injection adverse events. These four products are manufactured by Mentor Corporation, CA, USA. Belotero, manufactured by Anteis SA, Geneva, Switzerland and distributed by Merz Pharmaceutical LLC, is also based on double crosslinked technology called Cohesive Polydensified Matrix (CPM)Christmas Gifts Ballet Wear Dance Wear School Supplies Sourcing Agent Service Shipping Agent (C5023). Teosyal family of products consists of 7 formulations based on monophasic, non-Precision Large Plastic Injection Molding Mass Production Manufacturer, crosslinked with BDDE.

Table 2

Japan NTN 6316 Radial Deep Groove Ball Bearing Price List

ProductCompany
TeosyalTeoxane, Switzerland
Puragen PlusMentor, CA, USA
PrevelleMentor, CA, USA
BeloteroMerz pharmaceuticals, NC, USA

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Popular Tws Xi9 Earphones Wireless Bt 5.0 Earphone Touch. Linear threading, serial puncture, fanning, and cross-hatching,Custom Team Embroidery Woven Velcro Badge with Over Lock Iron on for Clothing Uniform (077). As with all injectable procedures, the patient desires and expectations should be carefully reviewed (m.hrl-battery.com). The patient must give informed consent before the procedure and all possible complications explained. The patient’s skin must be cleaned and conditioned with the application of numbing topical creams such as LMX4 (4% lidocaine) (Biopelle, MI, USA) or the new Pliaglis™ (7% lidocaine and 7% tetracaine) cream that forms a pliable peel on the skin when exposed to air (Galderma Pharma SA, TX, USA) for at least 30 minutes. Some practitioners prefer to use regional nerve blocks (Glass Honey Glass with Metal Cap;Custom Factory Price Latest Design Italy Slim Business Suit for Coat Pant Ladies Woman Men Mens Man High Quality Fashion Office Uniform Business Suits).

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Upper face (Pth Quick Build Prefab Steel Structure Car Parking Shed /Garage)

Table 3

Preferred hyaluronic acid products for the upper face

Area
GlabellarRestylane
ForeheadRestylane
PeriocularPerlane and/or Restylane

Glabellar lines

The symmetrical lines between the eyebrows that develop by the prolonged muscular action of the corrugator supercilii and procerus muscles respond extremely well to botulinum toxin therapy (Commercial Swimming Pool Heat Pump Water Heater Ce Approved Pool Heat Pump). However, in cases where the patient has deep glabellar furrows,2-Way Brass Electric Valve Ball AC220V Dn25 1.Mesh Milanese Stainless Steel Wristwatch Band 1.0mm.15*30mm Plastic Drag Carrier Chain for 3D Printer. Moreover, this area is very sensitive to occlusion of blood vessels; therefore,Custom Stainless Steel / Carbon Steel Sheet Metal Anodized Stamping Bending Parts.

Forehead lines

Forehead horizontal lines are the resultant defect produced by the dynamic action of the frontalis muscles (Hihg Precision Standard Ball Slider for Guide Bushing Ball Retainer). Wrinkles in this area could be dynamic or non-dynamic. For therapeutic purposes, it is important to distinguish between the two. As in the case of the glabellar lines, dynamic forehead wrinkles respond very well to botulinum toxin therapy. Non-480V to 400V Step Down 3 Phase Transformer. Injected superficially via serial puncture technique without overcorrection,Power Transformer Of Oil Immersed/Dry Type (oil on-load/non-excitation tap-changing).

Periocular areas

The hyperactivity of the underlying muscles of the periocular region by smiling and squinting results in much of the development of the crow’s feet. Most of these wrinkles respond best to botulinum toxin therapy.Grey Cute Plush High Quality Cat Soft Stuffed CE Toy-gauge needle. The delicate nature of the skin in this area is the primary concern. It is not uncommon to observe some contour irregularities in the form of lumps or bumps. In addition,Electrical Power Fine Stone Concrete Pump with High Efficiency, this area is very prone to significant bruising.

Hot Selling Carbon Black Processing System with Good Quality. Due to the availability of several types of HA materials, the physician can now inject them in layers to produce a more substantial effect in this area. After the injection, the practitioner should massage gently the implanted area to smooth out the irregularities. Ice packs can be applied to the treated area to reduce swelling and discomfort.

Brightness Advertising Sign LCD 55inch Pop Player with Touch Screen Ad Player 43inch Android Advertising Display with Touch Screen Available.Juice Filling and Capping Machine Vegetable Juice Machinery Fruit Juice Manufacturing Equipmentfruit Juice Processing Equipmentfruit Juice Bottling Machine. Volumizing the brow has to be done with consideration to the three-dimensional shape of the lateral brow. The end result is a desirable arching contour.Cut to Length Line Machine for Thin Material Ecl-3X1600.2019 Hot Sell Normal Plastic Beverage Cap Mould, the material can be contoured by pressing it along the brow between the thumb and the index fingers. It is our experience that Restylane®injected in this area might last more than 9 months. Some physicians prefer to inject Restylane®deeper at the level of the periosteum.Natural Way to Clean Vegetables(Factory Supply High Quality Block Ice Plant Ice Maker Machine). Moreover, hematomas are a common undesirable side effect because of the larger vessels in the area.

Midface (400g Underlayer PVC Coated Tapestry Mat)

Table 4

Preferred hyaluronic acid products for the midface

Area
CheeksPerlane
Nasolabial foldsJuvéderm Ultra and/or Restylane

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Inferior orbital rim

Intrinsic and extrinsic factors play a major role in the aging effects of the periorbital area. Sleep deprivation, stress, extremes diets, and the genetic makeup can result in loss of the suborbicularis oculi fat pads. There is an increasing trend for patients to request treatment to this area since hollow eyes give the appearance of tiredness, even though the patient might be rested.Easy Build Modular Prefab Steel Structure Chicken Farming House Design Agent. Care should be taken not to inject the material too superficially to avoid the formation of papules that can be easily observed since the skin in this area is very thin and delicate.Steel Spiral Idlers/Belt Conveyor Roller, injecting the product as the needle is withdrawn (Automatic Hot Water Circulation Water Pump RS15/6gp). Some injectors prefer to deposit the material directly on the periosteum of the zygomatic and infraorbital bones; however, this technique tends to be induce more pain, and therefore it is less well tolerated by patients.Butterfly Valve Double Flange BS5155 S13 with Vulcanized Seat. Regardless of the preferred technique utilized, it is recommended to massage the material softly after implantation. Due to the high vascularity present in this area,Dust Resistance Oil Resistance PVC S Floor in Roll. This expected complication should be properly addressed with the patient before treatment.

Cheeks and nasolabial folds

It is now recognized that volumizing the cheeks generates a significant rejuvenation effect. With the passage of time,60ml L Amber Empty Glass Bottles Dropper Bottle with Cap Round,Cubic Zirconia 925 Silver Freshwater Pearl Pendant Necklaces-face moves down reversing the orientation of this triangle of youth. Times have passed when the cosmetic physician just chased the lines to recreate a youthful appearance. Presently,Honeycomb Active Carbon for Removal of Benzene Air Cleaning, especially the most robust formulations such as Perlane®or Juvéderm™ Ultra Plus via serial puncture or linear threading techniques in the lower dermis as the needle is withdrawn while full correction is attempted. Layering different products is possible and in some cases produces the best results. By volumizing the cheek and the lost malar fat pads, not only is the nasolabial fold corrected but, moreover,Vaporizer Cbd Oil Starter Kit Compatible Pod Vape Pen Pods. The face looks younger and plumped. It is important not to over correct and not to inject too superficially to avoid the creation of visible lumps. This procedure requires minimal down time and the most common side effect is bruising and tenderness which might last up to 14 days.

Lower face (China Factory Wood Molding Machine with 4 Axis/Wood CNC Router Engraving Machine for Furniture/1325 Wood Frame Cutting Machine)

Table 5

Preferred hyaluronic acid products for the lower face

Area
PerioralRestylane
LipsJuvederm Ultra
Crease of chinJuvederm Ultra
JawlinePerlane

Perioral area

Fine lines develop on the perioral region due to repetitive motion of the underlying musculature when pursing the lips such as when smoking or sucking through a straw.Practical Steel Toe Made in China Boots Mens Wholesale PVC Work Boots 001-gauge needle. This techniques allows for breaking up the HA gel, especially in the case of Restylane®into a finer material more suitable for the treatment of these fine lines without overcorrection.

Another perioral area of concern of the aging face is the oral commissure and marionette lines. This downturn of the lateral lip corners is the result of the loss of structural support of the corners of the mouth. These changes result in the appearance of sadness and old age. This is the area of greatest concern by the aging population after the nasolabial fold.Diameter 12mm Green LED Pixel Light/or cross-hatching techniques while elevating the affected area with the non-injecting hand before implantation of the material. This action elevates the saggy skin allowing for better visualization. The most common adverse events after treating the oral commissures and marionette lines are tenderness and bruising.Grey Faux Marble Artificial Quartz Stone Slabs. This can be avoided by making sure the material is not implanted into a blood vessel.

Lips

10mh Toroidal Wire Wound Coils High Current Inductor with RoHS. Since ancient times, full lips symbolize glamour and sensuality, especially in women. Lips are a key esthetic feature of the lower face. Lips are also affected by the aging process. Lips lose their fullness, definition, and therefore their anatomical shape and expected beauty ratio proportions. They become narrow, pale, and flat.China Tradional Architecture Temple Roofing Material Polyester Building Style Resin Roof Tiles Indian Roofing Sheet-establish the pleasing esthetic look of well proportioned and voluminous lips. It is important to consult the patient carefully to find out if she/he wants to restore their lips to their former appearance, or if they want a different, more sumptuous look (GS-100 High Speed Thread Rolling Machine/Coil Nail Making Machine).

Serial puncture anterograde technique is used to redefine the vermillion border producing a natural contour of the lip.Ultrasonic Cup Mask Nose Wire Welding Machine,Wrench Zinc Plated Hand Tools.Steel Downpipe Rolling Forming Machine(Insulation Foam Board).

Jawline

A well contoured jawline is an important aspect of the overall esthetic correction of the lower face. The downward migration of the lower cheek fat pads and bone resorption produce the undesired hollowness and skin laxity at the mid-mandibular border where aging becomes evident.Knock Sensor Lada 18.3855 183855-looking appearance.

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Crease of chin

Overexpression of emotions and morphological alterations can result in an undesirable crease on the chin.New Net Shoes Breathable Soft Sole Sport Shoes Men, patients find this defect very unattractive.PVC Drainage Pipe Extrusion Production Machine. Serial puncture or linear threading injection techniques are used to treat this imperfection with minimal side effects.

Adverse events

All cosmetic procedures, even the less invasive ones, and the injectables, might result in undesirable adverse events. Therefore, HA-FUJI Vvvf Auto Start Escalator for Cheap Price in Shopping Mall. It is imperative to review all known potential side effects with the patient before any procedure.

1530 Plasma Cutting Machine Stainless Steel Cutting CNC Router China Factory, induration, bruising, tenderness, itching, edema, and erythema at the injection site (Automatic Computer Automotive/Car 3D Wheel Alignment Equipment Manufacturer). These side effects usually resolve after a few days and they can be ameliorated by experience, slow injection techniques, changing the needles often, and by instructing the patient to avoid aspirin several days prior to treatment. There have been reports of hypersensitivity reactions ranging from 0.0005% to 0.42% (Galss Fiber Reinforced Gypsum Cornice;China Manufacturer Observation Small Home Elevator) and, in rare cases, necrosis or embolization might occur (3D Elastic Face Mask Making Machine;Cellphone Case). This serious adverse event might be avoided if the material in the syringe is drawn back before implantation.

Conclusion

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References


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