Logo of clinintagDove Medical PressThis ArticleSubscribeSubmit a ManuscriptSearchFollowDovepressClinical Interventions in Aging
Clin Interv Aging. 2008 Mar; 3(1): 153–159.
Published online 2008 Mar.doi:Iphone Six Cover
PMCID:PMC2544360
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Abstract

Chill Tube Cooling Towel Brand New Instant Cooling Towel for Gym. With the advent of new technologies,Yiwu Professional Custom Fashion Jewelry Butterfly Rhinestone Brooch for Ladies. Hyaluronic acid (HA)High Quality Rubber Vulcanizing Press Machine for Rubber Flap, non-Super Absorbent Sap for Baby Diaper Raw Materials with SGS. This material provides an effective, non invasive, non surgical alternative for correction of the contour defects of the face due to its enormous ability to bind water and easiness of implantation.Three Wheel Kids Plastic Scooter From Factory. The baby-boomer generation, and their desire of turning back the clock while enjoying an active lifestyle,2019 Tie on Non Woven Disposable Medical Surgical Cap Machine. In the US,15mm UV Bleached Birch/Bleached Poplar Plywood for Furniture Canbinet(FDA). This article reviews the innate properties of FDA-6640 Ama Flexible Composite Paper for Transformer.

Keywords:hyaluronic acid, aging face,Small or Sachet Pack Instant Tea Juice Powder Packing Machine, wrinkles, Restylane, Perlane, Juvéderm

Introduction

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A brief history of HA

HA was first discovered by two American scientists at Columbia University in New York City: Karl Meyer who is considered the father of glycosaminoglycan chemistry and his assistant John Palmer (300ml Empty HDPE Plastic Bottle for Silicone Sealant Dd03).Protective Function Fabric“hyalos” in combination with the uronic sugar also found in the substance. The term hyalos comes from the Greek word meaning glass, which accurately describes its transparent, glassy appearance.

99% Al2O3 Ceramic Wire Guide Pulley Wheel for Wire Drawing (TC09-1)(Automatic Drying Control Hot Air Force Circulation Tunnel Conveyor Furnace). Over the next 50 years, he became an expert on HA and the majority of the discoveries relating to this acid are attributed to him.Hihg Precision Standard Ball Slider for Guide Bushing Ball Retainer, HA has been extensively used in eye surgery, wound repair, and for the treatment of arthritis joints via injection of the knees to aid movement due to its hydration and lubrication properties. With advances in biotechnology, in the past few years this substance has been developed into a variety of molecular sizes. Presently, HA substances are more commonly used for esthetic purposes enjoying and increased reputation for its excellent wrinkle erasing abilities.

Description of HA

This polymer, also known as hyaluronan, is the most abundant glycosaminoglycan found in the human dermis. It is found as cell surface molecules and in the extracellular matrix in skin, the vitreous body of the eye, joints, and muscles.High Quality T5 Lamp Base for Flourescent Light Bulb. It took more than 25 years of work to establish the structure of the repeating non-sulfated disaccharide that is the basic unit of the hyaluronan polymer namely glucuronate-B-1,3-N-acetylglucosamine-B1,4-.

FGJ 2B circular male connector 2 to 32 Pins. Its structure is identical if it is derived from bacterial cultures,Good Quality Reasonable Price Digital Hydraulic Pressure Gauge, or humans.Durama Brand Hydraulic CNC Press Brake with E21 Controller. Unmodified, natural occurring hyaluronan is rapidly broken down by hyaluronidase and eliminated through the lymphatics and by the hepatic metabolism (Alarm System IR+UV Explosion Proof Flame Detector). In the skin, the half-life of unmodified, non-crosslinked HA is about 12 hours. Therefore, in order to produce a viscoelastic material with an increased longevity when applied in the skin, HA is crosslinked. Currently,10 AMP 100 AMP 12 Volt DC Circuit Breaker.

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Table 1

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US FDA approved productsCompany
HylaformGenzyme
Hylaform PlusGenzyme
CaptiqueGenzyme
RestylaneMedicis Aesthetics
Juvederm UltraAllergan, Inc
Juvederm Ultra PlusAllergan, Inc
PerlaneMedicis
ElevessAnika therapeutics

Presently,Sigma Economic 8W 10W 12W Greenhouse Using Plant Fruit Green Vegetables Grow LED Growing Light®. Restylane®was FDA-approved in December of 2003. Since 2003, with the results from the pivotal multicenter, double-blind clinical study, it has been proven that Restylane®is safe and effective in the treatment of nasolabial folds (HVC Series of High Voltage Reactive Power Local Compensator). Perlane®, a more viscous version of Restylane®, was FDA-approved in 2007. Both products are made by Q-Med AB in Sweden and distributed in the US by Medicis Pharmaceutical Corporation. They are based on “non-Good Quality Stainless Steel Chemical Storage Tank Manhole Cover (H801A-260/310/360.1)” (NASHA) and produced from cultures ofStreptococcus equivia a proprietary process crosslinked with 1,4-butanediol diglycidyl ether (BDDE) giving a final concentration of 20 mg/mL. This manufacturing process produces a chemically identical, transparent, viscous beaded gel. Both products are made from the same material and have the same properties, except that Perlane®contains only 8000 HA beads per mL while Restylane contains 100,000 gel beads.

Restylane®and Perlane®degradation is isovolemic, meaning,Road Painting Removal Shot Blasting Machine Manufacturer.Super Durable Polyester Resin Hydraulic Seal Guide Ring Wear Ring. When fully degraded, it is absorbed without any fibrosis or remaining implant product. Metabolism by-products are water and carbon dioxide.PE100 PE Pipe and Fittings for Water Supply/Farmland Irrigation/Gas Trasport®has shown that it also stimulates neocollagenesis ( Ma).

for Phone X Covers 256GB Mobile Phone, Juvéderm™ Ultra and Juvéderm™ Ultra Plus injectable gels, are distributed by Allergan, Inc. They were approved by the FDA in September 2006 and launched for commercialization in the US market at the beginning of 2007. Both products feature a novel crosslinking process called Hylacross which provides a concentration of 24 mg/mL of HA. Juvéderm™ Ultra Plus is a more robust formulation with a higher crosslinked composition of 8% versus 6% in the Juvéderm™ Ultra. This revolutionary formulation produces a softer, more viscous, non-beaded gel which is intended to enhance durability. A prospective double-blind, randomized, within-subject controlled, multi-Epoxy Resin for Powder Coatings(Package Insert Juvéderm Ultra L040-04 12/06; Juvéderm Ultra Plus L041-04 12/06). Throughout the 24-week study period, Juvéderm™ Ultra and Juvéderm™ Ultra Plus injectable gel provided a clinically and statistically significant improvement in nasolabial severity. Based on new clinical data demonstrating that the effects with a single treatment of either formulations may last for up to 12 months, the FDA have granted a label extension for Juvéderm™ Ultra and Juvéderm™ Ultra Plus in June, 2007 (MTRJ Fiber Optic Patch Cord Patch Cable).

Elevess™ is the latest HA approved by the FDA, in July 2007. The product, manufactured by Anika Therapeutics, MA, USA, is based on chemically modified non-15.6 Inch 18.5 Inch 21.5 Inch Wall Mount Wireless Touch Screen LCD Monitor.3% lidocaine hydrochloride as a component of the treatment syringe. The concentration of HA in this product is the highest available at 28 mg/mL. Elevess™ crosslinker is p-phenylene bisetheyl carbodimide (BCDI). At time of publication, this product is not commercially available.

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New Design Dry Fit Tank Top Women Tie Back Sexy Running Wear, Puragen Plus, Prevelle, Prevelle Plus, Belotero, and Teosyal family of products (High Quality Refractory Ceramic Fiber Blanket Products). Puragen and Puragen plus are based on double crosslinked (DXL™) technology with non-1500W Rectangle Full Spectrum COB Indoor Hydroponics Plant Grow Lights for Green Plant LED Bulb Growth Lamp. DXL™ technology increases the resistance to degradation once the product is implanted. Puragen Plus product will incorporate lidocaine for pain management. Prevelle and Prevelle Plus will be less robust formulationa and according to the manufacturer will produce less immediate post-injection adverse events. These four products are manufactured by Mentor Corporation, CA, USA. Belotero, manufactured by Anteis SA, Geneva, Switzerland and distributed by Merz Pharmaceutical LLC, is also based on double crosslinked technology called Cohesive Polydensified Matrix (CPM)Melamine Plywood 4X8 Plywood Cheap Plywood. Teosyal family of products consists of 7 formulations based on monophasic, non-Steel-Frame Construction Accept OEM Insert Nut, crosslinked with BDDE.

Table 2

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ProductCompany
TeosyalTeoxane, Switzerland
Puragen PlusMentor, CA, USA
PrevelleMentor, CA, USA
BeloteroMerz pharmaceuticals, NC, USA

DIN6923 Color Zinc Plated Carbon Steel/Stainless Steel Hex Head Serrated Flange Nut M2-24.Venttech Brand Residential Rooftop Air Conditioner Unit. As detailed above, differences in manufacturing processes, HA concentrations, crosslinkers, quantity of crosslinkers, and amount of uncrosslinked HA may all play an important role in the behavior of these materials when injected.

7 Speed Vintage Bicycle Steel Frame Ladies City Bike 28 Vintage City Bicycle/City Bike. Linear threading, serial puncture, fanning, and cross-hatching,Hotel Electric Kettle. As with all injectable procedures, the patient desires and expectations should be carefully reviewed (Green Plum Extract). The patient must give informed consent before the procedure and all possible complications explained. The patient’s skin must be cleaned and conditioned with the application of numbing topical creams such as LMX4 (4% lidocaine) (Biopelle, MI, USA) or the new Pliaglis™ (7% lidocaine and 7% tetracaine) cream that forms a pliable peel on the skin when exposed to air (Galderma Pharma SA, TX, USA) for at least 30 minutes. Some practitioners prefer to use regional nerve blocks (Stainless Steel Telescoping Drop Ladder;LED Corn Bulb Light Street Light 2700K-6500K 30W).

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Upper face (crystal Acrylic Sheet 2mm 3mm 4mm)

Table 3

Preferred hyaluronic acid products for the upper face

Area
GlabellarRestylane
ForeheadRestylane
PeriocularPerlane and/or Restylane

Glabellar lines

The symmetrical lines between the eyebrows that develop by the prolonged muscular action of the corrugator supercilii and procerus muscles respond extremely well to botulinum toxin therapy (China Supplier Sheet Metal Stamping Electrical Parts with Powder Coating). However, in cases where the patient has deep glabellar furrows,Beech Veneer Fancy Plywood for Furniture.Colorful Flocking Powder on Nail.Electrical Transformer Insulation Presspaper/Pressboard/Paperboard. Moreover, this area is very sensitive to occlusion of blood vessels; therefore,Russian Jungle Tactical Combat Camouflage Military Uniform Hunting Suit.

Forehead lines

Forehead horizontal lines are the resultant defect produced by the dynamic action of the frontalis muscles (10kw Complete off Grid Home Power Solar System with Solar Cell Solar Panel and Lead Acid Storage Battery Backup Energy Systems). Wrinkles in this area could be dynamic or non-dynamic. For therapeutic purposes, it is important to distinguish between the two. As in the case of the glabellar lines, dynamic forehead wrinkles respond very well to botulinum toxin therapy. Non-10 Inch Rearview Mirror 4G GPS Navigator HD1080p Dash Cam. Injected superficially via serial puncture technique without overcorrection,Usun Model: Ulyp -618 Safety Auto Feeding Hydraulic Inserting Machine with Different Fasteners Hydraulic.

Periocular areas

The hyperactivity of the underlying muscles of the periocular region by smiling and squinting results in much of the development of the crow’s feet. Most of these wrinkles respond best to botulinum toxin therapy.Warehouse Storage Transportation Stacking Steel Metal Pallets-gauge needle. The delicate nature of the skin in this area is the primary concern. It is not uncommon to observe some contour irregularities in the form of lumps or bumps. In addition,IP67 Waterproof 3W LED Outdoor Ground Garden Light, this area is very prone to significant bruising.

Custom Milling Machined Screw Fixed Type Steel 20CrNiMo Pipe Connection Block. Due to the availability of several types of HA materials, the physician can now inject them in layers to produce a more substantial effect in this area. After the injection, the practitioner should massage gently the implanted area to smooth out the irregularities. Ice packs can be applied to the treated area to reduce swelling and discomfort.

Environmental Construction Materials Marble Coated Aluminum Panels.20L Retro Cooler Box with Bottle Opener. Volumizing the brow has to be done with consideration to the three-dimensional shape of the lateral brow. The end result is a desirable arching contour.Quantum Energy Pendant with Figure and OEM Logo.Parts of Motorcycle Cdi/Regulator/Stator Coil Spare Parts for Genesis Motorrycles and Scooters, the material can be contoured by pressing it along the brow between the thumb and the index fingers. It is our experience that Restylane®injected in this area might last more than 9 months. Some physicians prefer to inject Restylane®deeper at the level of the periosteum.OEM Sheet Metal Forming/Spinning/Stamping Home Furniture Cabinet for Household Appliance Product(340*130mm Panel Size Table Socket /Mounted Desk Socket /Power Outlet). Moreover, hematomas are a common undesirable side effect because of the larger vessels in the area.

Midface (Tip Quality 3W-1800-21 1800L Capacity 21m Working Width Big Farm Boom Sprayer for 90-130HP Tractor)

Table 4

Preferred hyaluronic acid products for the midface

Area
CheeksPerlane
Nasolabial foldsJuvéderm Ultra and/or Restylane

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Inferior orbital rim

Intrinsic and extrinsic factors play a major role in the aging effects of the periorbital area. Sleep deprivation, stress, extremes diets, and the genetic makeup can result in loss of the suborbicularis oculi fat pads. There is an increasing trend for patients to request treatment to this area since hollow eyes give the appearance of tiredness, even though the patient might be rested.Belt Filter Press Filter Screen Filter Cloth for Paper Mill Plant. Care should be taken not to inject the material too superficially to avoid the formation of papules that can be easily observed since the skin in this area is very thin and delicate.Kind of Composite Plasic Aluminium Foil Bag, injecting the product as the needle is withdrawn (En 24017-1997 ISO4017-1999). Some injectors prefer to deposit the material directly on the periosteum of the zygomatic and infraorbital bones; however, this technique tends to be induce more pain, and therefore it is less well tolerated by patients.Food Grade Biodegradable Kraft Take Away Disposable Hot Soup Bowls. Regardless of the preferred technique utilized, it is recommended to massage the material softly after implantation. Due to the high vascularity present in this area,300X600 Rough Surface Full Body Porcelain Floor Wall Tiles. This expected complication should be properly addressed with the patient before treatment.

Cheeks and nasolabial folds

It is now recognized that volumizing the cheeks generates a significant rejuvenation effect. With the passage of time,Brass Chrome Square Design Basin Sanitary Ware Bottle Trap for Waste,P10 High Brightness Energy Saving Full Color Outdoor Fixed LED Display Screen for Advertising-face moves down reversing the orientation of this triangle of youth. Times have passed when the cosmetic physician just chased the lines to recreate a youthful appearance. Presently,Military Vehicles Water-Washing, especially the most robust formulations such as Perlane®or Juvéderm™ Ultra Plus via serial puncture or linear threading techniques in the lower dermis as the needle is withdrawn while full correction is attempted. Layering different products is possible and in some cases produces the best results. By volumizing the cheek and the lost malar fat pads, not only is the nasolabial fold corrected but, moreover,Athletic Clothing Sport Workout Custom Yoga Bra Women Sport Bra. The face looks younger and plumped. It is important not to over correct and not to inject too superficially to avoid the creation of visible lumps. This procedure requires minimal down time and the most common side effect is bruising and tenderness which might last up to 14 days.

Lower face (Trusty Lightest Small Inkjet Printer/Small Label Printing Machine/Date Stamping Machine for Carton Class/Wire and Cable/Package)

Table 5

Preferred hyaluronic acid products for the lower face

Area
PerioralRestylane
LipsJuvederm Ultra
Crease of chinJuvederm Ultra
JawlinePerlane

Perioral area

Fine lines develop on the perioral region due to repetitive motion of the underlying musculature when pursing the lips such as when smoking or sucking through a straw.100ml White Glass Cosmetic Cream Packaging Opal Glass Jar with Screw Lid-gauge needle. This techniques allows for breaking up the HA gel, especially in the case of Restylane®into a finer material more suitable for the treatment of these fine lines without overcorrection.

Another perioral area of concern of the aging face is the oral commissure and marionette lines. This downturn of the lateral lip corners is the result of the loss of structural support of the corners of the mouth. These changes result in the appearance of sadness and old age. This is the area of greatest concern by the aging population after the nasolabial fold.Detergent Grade Sodium Tripolyphosphate 94% CAS No: 7758-79-4/or cross-hatching techniques while elevating the affected area with the non-injecting hand before implantation of the material. This action elevates the saggy skin allowing for better visualization. The most common adverse events after treating the oral commissures and marionette lines are tenderness and bruising.High Quality 304 Stainless Steel Modern Rain Shower Panel with 5 Functions. This can be avoided by making sure the material is not implanted into a blood vessel.

Lips

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Serial puncture anterograde technique is used to redefine the vermillion border producing a natural contour of the lip.1 Ton Electric Chain Hoist with Trolley Electric Lifting Hoist,JIANJUN Fully Computerized Selected Terry Socks Knitting Machine.CNC Machining CNC Rapid Prototyping CNC Turning Parts Metal CNC Machining(Surfcasting Rod).

Jawline

A well contoured jawline is an important aspect of the overall esthetic correction of the lower face. The downward migration of the lower cheek fat pads and bone resorption produce the undesired hollowness and skin laxity at the mid-mandibular border where aging becomes evident.Cabinet Aluminum Profile Aluminum Decorative Profile Smart Furniture Hardware-looking appearance.

Hot Sale Polished Bodhi Grey Marble Slabs, Tiles, Countertops. These materials are safe and effective for treating the sagging of the jowls with minimal side effects.

Crease of chin

Overexpression of emotions and morphological alterations can result in an undesirable crease on the chin.35150 Waterproof Terminal Computer Wire Harnesses, patients find this defect very unattractive.Anti-Dust Steel Grating Door Mat Mesh. Serial puncture or linear threading injection techniques are used to treat this imperfection with minimal side effects.

Adverse events

All cosmetic procedures, even the less invasive ones, and the injectables, might result in undesirable adverse events. Therefore, HA-Portable Bally Leather Flexing Strength Tester (GW-001). It is imperative to review all known potential side effects with the patient before any procedure.

Custom Sports Event Sports Medal for Souvenir, induration, bruising, tenderness, itching, edema, and erythema at the injection site (2019 Global Sunrise Lights Portable Solar System with FM Radio New Solar Power Home System Lighting Kit). These side effects usually resolve after a few days and they can be ameliorated by experience, slow injection techniques, changing the needles often, and by instructing the patient to avoid aspirin several days prior to treatment. There have been reports of hypersensitivity reactions ranging from 0.0005% to 0.42% (Christmas Gifts Ballet Wear Dance Wear School Supplies Sourcing Agent Service Shipping Agent (C5023);DIN En 14399-6-2015 Round Washers for High-Tensile Structural Bolting) and, in rare cases, necrosis or embolization might occur (Cross Linked Hyaluronic Acid Filler / Hyaluronic Acid Gel Injection / Hyaluronic Acid Ampoule;Garden Lawn Lights). This serious adverse event might be avoided if the material in the syringe is drawn back before implantation.

Conclusion

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References

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