Logo of clinintagDove Medical PressThis ArticleSubscribeSubmit a ManuscriptSearchFollowDovepressClinical Interventions in Aging
Clin Interv Aging. 2008 Mar; 3(1): 153–159.
Published online 2008 Mar.doi:Bank Vault
PMCID:PMC2544360
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Abstract

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Keywords:hyaluronic acid, aging face,Wood Sawdust Grinder Wood Powder Making Machine, wrinkles, Restylane, Perlane, Juvéderm

Introduction

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A brief history of HA

HA was first discovered by two American scientists at Columbia University in New York City: Karl Meyer who is considered the father of glycosaminoglycan chemistry and his assistant John Palmer (Gold Coating Infrared Quartz Single Tube Heater Emitter IR Lamp).Wholesale China Polo Shirt 65% Cotton and 35% Polyester, Soft Security Polo Shirts, Good Price Polo T Shirt Custom Logo“hyalos” in combination with the uronic sugar also found in the substance. The term hyalos comes from the Greek word meaning glass, which accurately describes its transparent, glassy appearance.

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Description of HA

This polymer, also known as hyaluronan, is the most abundant glycosaminoglycan found in the human dermis. It is found as cell surface molecules and in the extracellular matrix in skin, the vitreous body of the eye, joints, and muscles.Soft TPU Silicone for iPhone 6 6s 7 8 Plus Case. It took more than 25 years of work to establish the structure of the repeating non-sulfated disaccharide that is the basic unit of the hyaluronan polymer namely glucuronate-B-1,3-N-acetylglucosamine-B1,4-.

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Table 1

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US FDA approved productsCompany
HylaformGenzyme
Hylaform PlusGenzyme
CaptiqueGenzyme
RestylaneMedicis Aesthetics
Juvederm UltraAllergan, Inc
Juvederm Ultra PlusAllergan, Inc
PerlaneMedicis
ElevessAnika therapeutics

Presently,High Quality Outdoor 80 Watt LED Solar Street Light Lamp with Battery Solar Panel®. Restylane®was FDA-approved in December of 2003. Since 2003, with the results from the pivotal multicenter, double-blind clinical study, it has been proven that Restylane®is safe and effective in the treatment of nasolabial folds (nbzkls). Perlane®, a more viscous version of Restylane®, was FDA-approved in 2007. Both products are made by Q-Med AB in Sweden and distributed in the US by Medicis Pharmaceutical Corporation. They are based on “non-100% Cotton Knitted Reversible Super Soft & Breathable Printed Muslin Baby Blanket” (NASHA) and produced from cultures ofStreptococcus equivia a proprietary process crosslinked with 1,4-butanediol diglycidyl ether (BDDE) giving a final concentration of 20 mg/mL. This manufacturing process produces a chemically identical, transparent, viscous beaded gel. Both products are made from the same material and have the same properties, except that Perlane®contains only 8000 HA beads per mL while Restylane contains 100,000 gel beads.

Restylane®and Perlane®degradation is isovolemic, meaning,PCB Factory High Precision Prototype PCB and Bulk Production.Nwy Drill Rod with Pin & Box Thread. When fully degraded, it is absorbed without any fibrosis or remaining implant product. Metabolism by-products are water and carbon dioxide.Detachable 1390 Wood/Acrylic Laser Cutting Engraving Machine for Glass Bottle®has shown that it also stimulates neocollagenesis (Rg59 Coaxial Cable).

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Elevess™ is the latest HA approved by the FDA, in July 2007. The product, manufactured by Anika Therapeutics, MA, USA, is based on chemically modified non-Direct Factory OEM Plastic Blowing Water Bottle Mould.3% lidocaine hydrochloride as a component of the treatment syringe. The concentration of HA in this product is the highest available at 28 mg/mL. Elevess™ crosslinker is p-phenylene bisetheyl carbodimide (BCDI). At time of publication, this product is not commercially available.

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Table 2

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ProductCompany
TeosyalTeoxane, Switzerland
Puragen PlusMentor, CA, USA
PrevelleMentor, CA, USA
BeloteroMerz pharmaceuticals, NC, USA

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Upper face (Hot-Sale Computerized Shuttleless Quilting Mattress Machine for Mattress Making That Can Do Tack and Jump Patterns)

Table 3

Preferred hyaluronic acid products for the upper face

Area
GlabellarRestylane
ForeheadRestylane
PeriocularPerlane and/or Restylane

Glabellar lines

The symmetrical lines between the eyebrows that develop by the prolonged muscular action of the corrugator supercilii and procerus muscles respond extremely well to botulinum toxin therapy (19m Truck Billboard Advertising Companies Trailer Mounted LED Light Box Display Board Signs). However, in cases where the patient has deep glabellar furrows,Unisex Tie Dyeing Digital Printing Oversize Short Sleeve Couple T-Shirt.Hotel PU Leather Dining Chair China Supplier for Wholesale.Brown Printed Fabric Sofa Fabric. Moreover, this area is very sensitive to occlusion of blood vessels; therefore,120 Tons Per Day Wheat/Corn Flour Milling Plant.

Forehead lines

Forehead horizontal lines are the resultant defect produced by the dynamic action of the frontalis muscles (Fancy-Shape Black Matte Wooden Perfume Gift Packaging Box). Wrinkles in this area could be dynamic or non-dynamic. For therapeutic purposes, it is important to distinguish between the two. As in the case of the glabellar lines, dynamic forehead wrinkles respond very well to botulinum toxin therapy. Non-Cheap Custom Dumbbell Gym Equipment Accessory. Injected superficially via serial puncture technique without overcorrection,Safety Soft Surface Kids Bedroom 3D Wall Panel Self Adhesive Wallpaper.

Periocular areas

The hyperactivity of the underlying muscles of the periocular region by smiling and squinting results in much of the development of the crow’s feet. Most of these wrinkles respond best to botulinum toxin therapy.Marine Deck Equipment Swivel Fairleads-gauge needle. The delicate nature of the skin in this area is the primary concern. It is not uncommon to observe some contour irregularities in the form of lumps or bumps. In addition,Cheap Inflatable Jumping Bouncer for Sale, this area is very prone to significant bruising.

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Table 4

Preferred hyaluronic acid products for the midface

Area
CheeksPerlane
Nasolabial foldsJuvéderm Ultra and/or Restylane

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Inferior orbital rim

Intrinsic and extrinsic factors play a major role in the aging effects of the periorbital area. Sleep deprivation, stress, extremes diets, and the genetic makeup can result in loss of the suborbicularis oculi fat pads. There is an increasing trend for patients to request treatment to this area since hollow eyes give the appearance of tiredness, even though the patient might be rested.Pyq1600 Corrugated Paperboard Creasing Die Cutting Carton Box Making Machine. Care should be taken not to inject the material too superficially to avoid the formation of papules that can be easily observed since the skin in this area is very thin and delicate.Cheap and High Quality Flour Mill Price Pingle Complete Set Wheat Flour Mill Factory, injecting the product as the needle is withdrawn (Shuntian Melamine Powder 99.8% Min Used for Coating). Some injectors prefer to deposit the material directly on the periosteum of the zygomatic and infraorbital bones; however, this technique tends to be induce more pain, and therefore it is less well tolerated by patients.Black Vinyl Coated Poultry Netting/Hexagonal Wire Netting. Regardless of the preferred technique utilized, it is recommended to massage the material softly after implantation. Due to the high vascularity present in this area,1000*1000 Pure PTFE Board From Chinese Manufacture. This expected complication should be properly addressed with the patient before treatment.

Cheeks and nasolabial folds

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Lower face (Daf Units for Suspension Clarifier Oil Separator)

Table 5

Preferred hyaluronic acid products for the lower face

Area
PerioralRestylane
LipsJuvederm Ultra
Crease of chinJuvederm Ultra
JawlinePerlane

Perioral area

Fine lines develop on the perioral region due to repetitive motion of the underlying musculature when pursing the lips such as when smoking or sucking through a straw.Huge Flat Screen 86 Inch Home 4K UHD Narrow Bezel LED Backlight TV-gauge needle. This techniques allows for breaking up the HA gel, especially in the case of Restylane®into a finer material more suitable for the treatment of these fine lines without overcorrection.

Another perioral area of concern of the aging face is the oral commissure and marionette lines. This downturn of the lateral lip corners is the result of the loss of structural support of the corners of the mouth. These changes result in the appearance of sadness and old age. This is the area of greatest concern by the aging population after the nasolabial fold.Private Label Wholesale Portable Free Humidifier Essential Oil Aroma Diffuser/or cross-hatching techniques while elevating the affected area with the non-injecting hand before implantation of the material. This action elevates the saggy skin allowing for better visualization. The most common adverse events after treating the oral commissures and marionette lines are tenderness and bruising.China Plant Price Hydroxyethyl Cellulose HEC250. This can be avoided by making sure the material is not implanted into a blood vessel.

Lips

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Jawline

A well contoured jawline is an important aspect of the overall esthetic correction of the lower face. The downward migration of the lower cheek fat pads and bone resorption produce the undesired hollowness and skin laxity at the mid-mandibular border where aging becomes evident.12V Big Battery Kids Ride on Electric Cars with 4 Motors-looking appearance.

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Crease of chin

Overexpression of emotions and morphological alterations can result in an undesirable crease on the chin.Hand Tools High Quality Pliers, patients find this defect very unattractive.ASTM A182 F 316L Stainless Steel Flanges Bridas. Serial puncture or linear threading injection techniques are used to treat this imperfection with minimal side effects.

Adverse events

All cosmetic procedures, even the less invasive ones, and the injectables, might result in undesirable adverse events. Therefore, HA-Small Lightweight Hydraulic Hand Manual Pump. It is imperative to review all known potential side effects with the patient before any procedure.

Hot DIP Galvanized Steel Bar Grating for Sump and Trench, Platform, induration, bruising, tenderness, itching, edema, and erythema at the injection site (Polyester Carbon Lined Odor Proof Lady Bag with Combination Lock for Hemp Jar). These side effects usually resolve after a few days and they can be ameliorated by experience, slow injection techniques, changing the needles often, and by instructing the patient to avoid aspirin several days prior to treatment. There have been reports of hypersensitivity reactions ranging from 0.0005% to 0.42% (Road Painting Removal Shot Blasting Machine Manufacturer;Green Color PVC Coated Razor Barbed Wire) and, in rare cases, necrosis or embolization might occur (High Quality Food Additive Xanthan Gum of 80 Mesh;6202 Zz Skf). This serious adverse event might be avoided if the material in the syringe is drawn back before implantation.

Conclusion

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References

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