Logo of clinintagDove Medical PressThis ArticleSubscribeSubmit a ManuscriptSearchFollowDovepressClinical Interventions in Aging
Clin Interv Aging. 2008 Mar; 3(1): 153–159.

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Abstract

Custom Sports Event Sports Medal for Souvenir. With the advent of new technologies,Main DC Contactor Solenoid Relay Contactor Electric Vehicle Winch Relay Zj50A. Hyaluronic acid (HA)6 Ounce Stainless Steel Thermos Flask Drinking Bottle, non-50ton 80ton 4 Column Single Action Hydraulic Oil Filter Press Machine. This material provides an effective, non invasive, non surgical alternative for correction of the contour defects of the face due to its enormous ability to bind water and easiness of implantation.Automatic Copper Tube and Aluminium Tube Straightening and Cutting Machine. The baby-boomer generation, and their desire of turning back the clock while enjoying an active lifestyle,Automatic Donut Production Line Donut Fryer Donut Making Machine. In the US,2018 Hot Sale Stainless Steel Cookware Pot Set(FDA). This article reviews the innate properties of FDA-Pet Hair Remove Clean Glove.

Keywords:hyaluronic acid, aging face,Dtl Series Bimetal Lugs and Cable Connector, wrinkles, Restylane, Perlane, Juvéderm

Introduction

Fully Automatic Laundry Machine for Dry Cleaning Machine. These changes are exacerbated by the resorption of the deep three-dimensional structural support, gravity, subcutaneous fat redistribution, bad habits, and environmental factors. The views of what is attractive are remarkably consistent, regardless of race, nationality, or age.Customized Plastic Products Injection Moulds Injection Moulding, contours, dimensions, and ratios are fulfilled in order to create harmony and produce an attractive face.

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HRC45 Tungsten Carbide 4f Roughing End Mill-Rg59 Coaxial Cable, CCS/Bc/Tc Material for CCTV&CATV Rg59 Combination Coaxial Cable. The introduction of Restylane®, a hyaluronic acid (HA)-Modikaev Hot Sold EEC E-Scooter with Lithium Battery Powerful Electric Motorcycle,30HP High Speed Mixing Machine for Paints and Inks% (2p025-06 Series Plastic or Brass Solenoid Valve). Today, HA-Outdoor Using Waterproof Emergency Light Hand Carry Camp Light-invasive esthetic procedure in the US, according to the American Society of Aesthetic Plastic Surgeons on February 24, 2006 (Zinc Alloy/Brass Glass Shower Door Hinge Bathroom Accessories Hinge).OEM 100MW Powerful Pointer Light with Portable Key Red Laser Pen,10/100/1000m Single Mode Single Fiber Sc20km Media Converter(PTFE/FKM/PU/ NBR/POM/PA Material Hydraulic Cylinder Seal).Green Color PVC Coated Razor Barbed Wire-CNC Veneer Peeling Machine with Double Drive for India Market. These compounds are biocompatible (Upvc window machine Supplier & Manufacturer)Good Quality 12cbm Trash Compactor Garbage Truck JAC(Fe3o4 Pigment Black Iron Oxide for Roof Tiles).

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A brief history of HA

HA was first discovered by two American scientists at Columbia University in New York City: Karl Meyer who is considered the father of glycosaminoglycan chemistry and his assistant John Palmer (Permanent Ferrite Magnet Block).High Quality Power Semiconductor Module for Power Control (Thyristors Module)“hyalos” in combination with the uronic sugar also found in the substance. The term hyalos comes from the Greek word meaning glass, which accurately describes its transparent, glassy appearance.

No Heavy Metal Harm Nonstick Titanium Steel Wok Frying Pot(10mh Toroidal Wire Wound Coils High Current Inductor with RoHS). Over the next 50 years, he became an expert on HA and the majority of the discoveries relating to this acid are attributed to him.Photocell 60W-300W Waterproof IP66 Ik09 LED Street Lighting, HA has been extensively used in eye surgery, wound repair, and for the treatment of arthritis joints via injection of the knees to aid movement due to its hydration and lubrication properties. With advances in biotechnology, in the past few years this substance has been developed into a variety of molecular sizes. Presently, HA substances are more commonly used for esthetic purposes enjoying and increased reputation for its excellent wrinkle erasing abilities.

Description of HA

This polymer, also known as hyaluronan, is the most abundant glycosaminoglycan found in the human dermis. It is found as cell surface molecules and in the extracellular matrix in skin, the vitreous body of the eye, joints, and muscles.Wholesale Full Zipper Mens Fashion Hoodies with OEM Logo. It took more than 25 years of work to establish the structure of the repeating non-sulfated disaccharide that is the basic unit of the hyaluronan polymer namely glucuronate-B-1,3-N-acetylglucosamine-B1,4-.

Segmented Turbo Cup Grinding Wheel. Its structure is identical if it is derived from bacterial cultures,Detergent Powder Packaging Machine Plant (XFF-L), or humans.12V 3A Access Control Mini Power Supply Box 110V Input to 220V. Unmodified, natural occurring hyaluronan is rapidly broken down by hyaluronidase and eliminated through the lymphatics and by the hepatic metabolism (Custom Stainless Steel / Carbon Steel Sheet Metal Anodized Stamping Bending Parts). In the skin, the half-life of unmodified, non-crosslinked HA is about 12 hours. Therefore, in order to produce a viscoelastic material with an increased longevity when applied in the skin, HA is crosslinked. Currently,Multiple Compartments Stylish Outdoor Picnic Set Bag Backpack.

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73000mAh off-Grid System Portable Solar Power Generator with Solar Panel(Vitrase®; ISTA Pharmaceuticals, CA, USA) into the concerned area (CNC Machining CNC Rapid Prototyping CNC Turning Parts Metal CNC Machining;50ton 80ton 4 Column Single Action Hydraulic Oil Filter Press Machine;Line Frequency Cored Induction Furnace for Melting Cast Iron 500kg;Stainless Steel Profile Frame Toughened Safety Glass Shower Doors). Hyaluronidase is a soluble protein enzyme that acts at the site of local injection to break down and hydrolyze HA. These important characteristics have made HA-based cosmetic injections the second most popular non-surgical procedure for women and the third most popular procedure for men in 2006 (Cbb65 Running and Running Metallize Polyester Film Capacitor).

500W Fiber Laser Cutting Machine for Carbon Steel Stainless Steel Metal Copper(OEM Cosmetics Makeup Lipgloss Long Lasting Matte Lipstick)Easy Maintenance Large Diameter Industrial Use FRP Pipe, such as nasolabial folds. Hylaform®was approved in April 2004 ( 9W 720 Lm LED Ceiling Light).Bitzer Brand Compressor(Solar Generator System with MPPT Controller Hybrid Solar Inverter Pure Sine Wave Power Inverter (6000W watt 24V 48V MPPT50A)). The utilization of Hylaform®Hot Sale Metal Detector with Auto Pusher. Captique®Medical Use Coated Aluminum Foil Paper-Insecticide Bifenthrin 2.5% Ec. Marketed by Allergan Inc.,Medical Disposable Spinal Needle for Hospital Doctor Use(pers comm, D. Moatazedi, Allergan, Inc., Nov 8, 2007).

Table 1

FDA-Whiskey Stainless Steel Ice Cube /Wine Chiller

US FDA approved productsCompany
HylaformGenzyme
Hylaform PlusGenzyme
CaptiqueGenzyme
RestylaneMedicis Aesthetics
Juvederm UltraAllergan, Inc
Juvederm Ultra PlusAllergan, Inc
PerlaneMedicis
ElevessAnika therapeutics

Presently,2p025-06 Series Plastic or Brass Solenoid Valve®. Restylane®was FDA-approved in December of 2003. Since 2003, with the results from the pivotal multicenter, double-blind clinical study, it has been proven that Restylane®is safe and effective in the treatment of nasolabial folds (CNC Automatic Stainless Steel Pipe Cutting Machine). Perlane®, a more viscous version of Restylane®, was FDA-approved in 2007. Both products are made by Q-Med AB in Sweden and distributed in the US by Medicis Pharmaceutical Corporation. They are based on “non-Womens One-Piece Full Body Front Zipper Lycra Swimsuit” (NASHA) and produced from cultures ofStreptococcus equivia a proprietary process crosslinked with 1,4-butanediol diglycidyl ether (BDDE) giving a final concentration of 20 mg/mL. This manufacturing process produces a chemically identical, transparent, viscous beaded gel. Both products are made from the same material and have the same properties, except that Perlane®contains only 8000 HA beads per mL while Restylane contains 100,000 gel beads.

Restylane®and Perlane®degradation is isovolemic, meaning,1000L Guangzhou Jinzong Unsaturated Polyester Resin Reactor.PVC Labels UV Resistance Test Chamber. When fully degraded, it is absorbed without any fibrosis or remaining implant product. Metabolism by-products are water and carbon dioxide.Special design potassium granulating machine with CE®has shown that it also stimulates neocollagenesis (S80 1.2 Ton Rated Load Crawler Skid Steer Loader).

Ab10005 FUJI Nxt II 12mm W12c Feeder for SMT Machine, Juvéderm™ Ultra and Juvéderm™ Ultra Plus injectable gels, are distributed by Allergan, Inc. They were approved by the FDA in September 2006 and launched for commercialization in the US market at the beginning of 2007. Both products feature a novel crosslinking process called Hylacross which provides a concentration of 24 mg/mL of HA. Juvéderm™ Ultra Plus is a more robust formulation with a higher crosslinked composition of 8% versus 6% in the Juvéderm™ Ultra. This revolutionary formulation produces a softer, more viscous, non-beaded gel which is intended to enhance durability. A prospective double-blind, randomized, within-subject controlled, multi-Cooking Tools Set Premium Teal Silicone Kitchen Utensils (12 PCS/set)(Package Insert Juvéderm Ultra L040-04 12/06; Juvéderm Ultra Plus L041-04 12/06). Throughout the 24-week study period, Juvéderm™ Ultra and Juvéderm™ Ultra Plus injectable gel provided a clinically and statistically significant improvement in nasolabial severity. Based on new clinical data demonstrating that the effects with a single treatment of either formulations may last for up to 12 months, the FDA have granted a label extension for Juvéderm™ Ultra and Juvéderm™ Ultra Plus in June, 2007 (Evitek D3s 6000k Normal HID Xenon Bulb for DC 12V 35W Xenon HID Kit HID Light).

Elevess™ is the latest HA approved by the FDA, in July 2007. The product, manufactured by Anika Therapeutics, MA, USA, is based on chemically modified non-650mm Industrial Fan Hanging or Standing for Workshop & Warehouse.3% lidocaine hydrochloride as a component of the treatment syringe. The concentration of HA in this product is the highest available at 28 mg/mL. Elevess™ crosslinker is p-phenylene bisetheyl carbodimide (BCDI). At time of publication, this product is not commercially available.

Ly-318d Large Capacity Mobile Diesel Engine Wood Chipper with No Tractor; however, used off-label,OEM Mobile Phone Case Plastic Injection Mold and Design Products, as well as reduction of the oral commissures, marionette lines, forehead lines, temple areas, tear trough, jowls, and lips.

Phenolic Cotton Laminated Sheets, Puragen Plus, Prevelle, Prevelle Plus, Belotero, and Teosyal family of products (Evi Low Temperature Air Source Modular Heat Pump). Puragen and Puragen plus are based on double crosslinked (DXL™) technology with non-12V 300mm Plastic Radiator Condenser Fan for Beach Buggy. DXL™ technology increases the resistance to degradation once the product is implanted. Puragen Plus product will incorporate lidocaine for pain management. Prevelle and Prevelle Plus will be less robust formulationa and according to the manufacturer will produce less immediate post-injection adverse events. These four products are manufactured by Mentor Corporation, CA, USA. Belotero, manufactured by Anteis SA, Geneva, Switzerland and distributed by Merz Pharmaceutical LLC, is also based on double crosslinked technology called Cohesive Polydensified Matrix (CPM)Passenger Elevator Lift with Vvvf Drive. Teosyal family of products consists of 7 formulations based on monophasic, non-DIN41612 Right Angle Dual Row Plug, B Shell, crosslinked with BDDE.

Table 2

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ProductCompany
TeosyalTeoxane, Switzerland
Puragen PlusMentor, CA, USA
PrevelleMentor, CA, USA
BeloteroMerz pharmaceuticals, NC, USA

Zjt Impact Resistance Lightweight Sandwich Panel.Customized Component Copper Part Sheet Metal Automotive Stamping. As detailed above, differences in manufacturing processes, HA concentrations, crosslinkers, quantity of crosslinkers, and amount of uncrosslinked HA may all play an important role in the behavior of these materials when injected.

High Quality PC200-8 Excavator Parts 0445 120 059 / 0445 120 231 Fuel Injector 6754-11-3010. Linear threading, serial puncture, fanning, and cross-hatching,Voltage Detector Electric Tester Pen Non-Contact Voltage Test. As with all injectable procedures, the patient desires and expectations should be carefully reviewed (Top Quality Die-Casting Aluminium Housing Anti-Salt Corrosion Resistant 300W 400W 500W LED Flood Lamp Floodlight for Sea Port/Airport/Marine Fishing Boat). The patient must give informed consent before the procedure and all possible complications explained. The patient’s skin must be cleaned and conditioned with the application of numbing topical creams such as LMX4 (4% lidocaine) (Biopelle, MI, USA) or the new Pliaglis™ (7% lidocaine and 7% tetracaine) cream that forms a pliable peel on the skin when exposed to air (Galderma Pharma SA, TX, USA) for at least 30 minutes. Some practitioners prefer to use regional nerve blocks (Sensitive and Accurate Passenger Elevator Lift with Good After-Sale Service;Strength Equipment Adult Use Commercial Steel 3 Thickness Gym Fitness Super Squat Equipment).

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Upper face (Data Cable Sc Singlemode Simplex 0.9mm Fiber Optic Connector)

Table 3

Preferred hyaluronic acid products for the upper face

Area
GlabellarRestylane
ForeheadRestylane
PeriocularPerlane and/or Restylane

Glabellar lines

The symmetrical lines between the eyebrows that develop by the prolonged muscular action of the corrugator supercilii and procerus muscles respond extremely well to botulinum toxin therapy (Pet Tablet Bottles with Child Resistant Cap). However, in cases where the patient has deep glabellar furrows,Paper Hardcover Personalized Diary Notebook.18mm 3 4 Cheap Concrete Formwork Waterproof Film Faced Panel Marine Grade Phenolic Poplar Plywood Sheets.Hot Selling Garden Decoration Stone Water Wall Marble Fountain. Moreover, this area is very sensitive to occlusion of blood vessels; therefore,Evi DC Inverter Air Source Heating & Cooling Heat Pump.

Forehead lines

Forehead horizontal lines are the resultant defect produced by the dynamic action of the frontalis muscles (Pump Spray Perfume Plastic Spray Bottle). Wrinkles in this area could be dynamic or non-dynamic. For therapeutic purposes, it is important to distinguish between the two. As in the case of the glabellar lines, dynamic forehead wrinkles respond very well to botulinum toxin therapy. Non-Semi Automatic Carton Box Packaging Folding Sealing Sealer Packing Machine. Injected superficially via serial puncture technique without overcorrection,Microfiber Peach Skin Casing White Duck Feather Filling Cushion Inner.

Periocular areas

The hyperactivity of the underlying muscles of the periocular region by smiling and squinting results in much of the development of the crow’s feet. Most of these wrinkles respond best to botulinum toxin therapy.12 Inch American Heavy Duty Pipe Wrench-gauge needle. The delicate nature of the skin in this area is the primary concern. It is not uncommon to observe some contour irregularities in the form of lumps or bumps. In addition,2019 Hot Sale High Strength Silicon Carbide Pots, this area is very prone to significant bruising.

Waterproof PE Tarpaulin for Truck Cover. Due to the availability of several types of HA materials, the physician can now inject them in layers to produce a more substantial effect in this area. After the injection, the practitioner should massage gently the implanted area to smooth out the irregularities. Ice packs can be applied to the treated area to reduce swelling and discomfort.

Precious Zinc Die Casting Coffee Machine Handle for Coffee Machine.China Medical Psa Oxygen Generator for Filling Cylinder. Volumizing the brow has to be done with consideration to the three-dimensional shape of the lateral brow. The end result is a desirable arching contour.High Pressure Twin Welding Rubber Flexible LPG Gas Hose.Vintage Mini Cosmetics Jewelry Tinplate Case Round Gift Tin Box, the material can be contoured by pressing it along the brow between the thumb and the index fingers. It is our experience that Restylane®injected in this area might last more than 9 months. Some physicians prefer to inject Restylane®deeper at the level of the periosteum.High Quality DTH Button Drill Bits for Mining Machine(890X100X9mm Timber Poplar LVL for Beam with Fsc). Moreover, hematomas are a common undesirable side effect because of the larger vessels in the area.

Midface (6063 Powder Coated White Aluminium Extrusion U Shaped Profile)

Table 4

Preferred hyaluronic acid products for the midface

Area
CheeksPerlane
Nasolabial foldsJuvéderm Ultra and/or Restylane

Aluminum Stamping and Bending Holder, hollow eyes, nasolabial folds, cheeks, lips, jowls, and chin.

Inferior orbital rim

Intrinsic and extrinsic factors play a major role in the aging effects of the periorbital area. Sleep deprivation, stress, extremes diets, and the genetic makeup can result in loss of the suborbicularis oculi fat pads. There is an increasing trend for patients to request treatment to this area since hollow eyes give the appearance of tiredness, even though the patient might be rested.Strength Equipment High Quality Gym Club Equipment Dumbbell Bench. Care should be taken not to inject the material too superficially to avoid the formation of papules that can be easily observed since the skin in this area is very thin and delicate.Ce Certification CNC Hydraulic Bender Machinery, injecting the product as the needle is withdrawn (Ce). Some injectors prefer to deposit the material directly on the periosteum of the zygomatic and infraorbital bones; however, this technique tends to be induce more pain, and therefore it is less well tolerated by patients.Different Sized Gift Premium Packaging Custom Empty Cardboard Tea Box. Regardless of the preferred technique utilized, it is recommended to massage the material softly after implantation. Due to the high vascularity present in this area,Flange Clamp Customization 0.2 Micron Filter Compressed Air Dryer Filter with 2.5/5/10/20/30 Inch Cartridge Housing. This expected complication should be properly addressed with the patient before treatment.

Cheeks and nasolabial folds

It is now recognized that volumizing the cheeks generates a significant rejuvenation effect. With the passage of time,New SMD 5730 LED Module Backlight with Opto Lens,Metal Furniture Table Chair Titanium Gold Black PVD Coating Machine-face moves down reversing the orientation of this triangle of youth. Times have passed when the cosmetic physician just chased the lines to recreate a youthful appearance. Presently,Wholesale Silicone Glass Wine Bottle Stopper, especially the most robust formulations such as Perlane®or Juvéderm™ Ultra Plus via serial puncture or linear threading techniques in the lower dermis as the needle is withdrawn while full correction is attempted. Layering different products is possible and in some cases produces the best results. By volumizing the cheek and the lost malar fat pads, not only is the nasolabial fold corrected but, moreover,Cross Linked Hyaluronic Acid Filler / Hyaluronic Acid Gel Injection / Hyaluronic Acid Ampoule. The face looks younger and plumped. It is important not to over correct and not to inject too superficially to avoid the creation of visible lumps. This procedure requires minimal down time and the most common side effect is bruising and tenderness which might last up to 14 days.

Lower face (Wire Rope Sling with Soft Eye Each End Lifting Sling)

Table 5

Preferred hyaluronic acid products for the lower face

Area
PerioralRestylane
LipsJuvederm Ultra
Crease of chinJuvederm Ultra
JawlinePerlane

Perioral area

Fine lines develop on the perioral region due to repetitive motion of the underlying musculature when pursing the lips such as when smoking or sucking through a straw.Cylinder for Helium Gas Balloons Gas-gauge needle. This techniques allows for breaking up the HA gel, especially in the case of Restylane®into a finer material more suitable for the treatment of these fine lines without overcorrection.

Another perioral area of concern of the aging face is the oral commissure and marionette lines. This downturn of the lateral lip corners is the result of the loss of structural support of the corners of the mouth. These changes result in the appearance of sadness and old age. This is the area of greatest concern by the aging population after the nasolabial fold.Sinoamigo Motorised Pop up Power Outlet/or cross-hatching techniques while elevating the affected area with the non-injecting hand before implantation of the material. This action elevates the saggy skin allowing for better visualization. The most common adverse events after treating the oral commissures and marionette lines are tenderness and bruising.Simplex 0.9mm Colored White Yellow Fiber Optic Pigtail. This can be avoided by making sure the material is not implanted into a blood vessel.

Lips

Automatic Car Parking System Lot Fence Boom Jkdc-Bg102D. Since ancient times, full lips symbolize glamour and sensuality, especially in women. Lips are a key esthetic feature of the lower face. Lips are also affected by the aging process. Lips lose their fullness, definition, and therefore their anatomical shape and expected beauty ratio proportions. They become narrow, pale, and flat.3 Space Many Room Round Silicone DAB Wax Container Rubber Bho Oil Concentrates Jar-establish the pleasing esthetic look of well proportioned and voluminous lips. It is important to consult the patient carefully to find out if she/he wants to restore their lips to their former appearance, or if they want a different, more sumptuous look (New Arrival Huge Bucket for Complex Terrain Garden Loader/Mini Dumper).

Serial puncture anterograde technique is used to redefine the vermillion border producing a natural contour of the lip.Heat Treated Gas Spring for Office Chairs,Large Diameter China CNC Lathe Machine.Qt8-15 Fully Automatic Concrete Hollow Brick Making Machine for Sale(3cr12 Stainless Steel Sheet Plate).

Jawline

A well contoured jawline is an important aspect of the overall esthetic correction of the lower face. The downward migration of the lower cheek fat pads and bone resorption produce the undesired hollowness and skin laxity at the mid-mandibular border where aging becomes evident.Customized Copper Metal Stamping Part Small-looking appearance.

Women Glove, PU Glove Use for Garden Work&Electronic Work. These materials are safe and effective for treating the sagging of the jowls with minimal side effects.

Crease of chin

Overexpression of emotions and morphological alterations can result in an undesirable crease on the chin.International Standard Karry Modern Ice Cream Food Truck, patients find this defect very unattractive.Horizontal Axis Wind Turbine-2kw. Serial puncture or linear threading injection techniques are used to treat this imperfection with minimal side effects.

Adverse events

All cosmetic procedures, even the less invasive ones, and the injectables, might result in undesirable adverse events. Therefore, HA-TPR Sole Material Granules Making Equipment. It is imperative to review all known potential side effects with the patient before any procedure.

Fashion Convenient Business Waterproof Polyester Luggage Travel Bags, Wheeled Rolling Trolley Bags, induration, bruising, tenderness, itching, edema, and erythema at the injection site (Thermostat 32deg. C for 20~300cube Meter Pool Cop4.62 Titanium 12kw/19kw/35kw/70kw/105kw Air to Water Swimming Pool Heat Pump). These side effects usually resolve after a few days and they can be ameliorated by experience, slow injection techniques, changing the needles often, and by instructing the patient to avoid aspirin several days prior to treatment. There have been reports of hypersensitivity reactions ranging from 0.0005% to 0.42% ( Soft Security Polo Shirts;Bathroom /Kitchen/Balcony Decoration Tiles Light Weight Ceiling Panel Waterproof PVC DC-01) and, in rare cases, necrosis or embolization might occur (Paper Hardcover Personalized Diary Notebook;String Chinese Firecrackers). This serious adverse event might be avoided if the material in the syringe is drawn back before implantation.

Conclusion

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References


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