Logo of clinintagDove Medical PressThis ArticleSubscribeSubmit a ManuscriptSearchFollowDovepressClinical Interventions in Aging
Clin Interv Aging. 2008 Mar; 3(1): 153–159.
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Abstract

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Keywords:hyaluronic acid, aging face,Black 3D Air Mesh Auto Seat Cover, wrinkles, Restylane, Perlane, Juvéderm

Introduction

Wholesale Mini Polish Pen Shaped Electric Manicure Pedicure Nail Drill. These changes are exacerbated by the resorption of the deep three-dimensional structural support, gravity, subcutaneous fat redistribution, bad habits, and environmental factors. The views of what is attractive are remarkably consistent, regardless of race, nationality, or age.9mm DC12V Waterproof High Quality Outdoor Exposed LED Pixel Light, contours, dimensions, and ratios are fulfilled in order to create harmony and produce an attractive face.

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A brief history of HA

HA was first discovered by two American scientists at Columbia University in New York City: Karl Meyer who is considered the father of glycosaminoglycan chemistry and his assistant John Palmer (Plastic PVC/PE (HDPE&LDPE) /PPR Electricity Conduit Tube/ Water Sewage& Pressure Pipe (profile) (extruder-winding) Extrusion &Extruding Production Line).Sweet Potato Tapioca Cassava Potato Starch Noodle Maker“hyalos” in combination with the uronic sugar also found in the substance. The term hyalos comes from the Greek word meaning glass, which accurately describes its transparent, glassy appearance.

American Style Supermarket Shop Gondola Grocery Convenience Store Retail Display Shelving(Plain Polished Stainless Steel Cold Drawn Tube). Over the next 50 years, he became an expert on HA and the majority of the discoveries relating to this acid are attributed to him.Nylon Hose PA6 Hose PA12 Tube, HA has been extensively used in eye surgery, wound repair, and for the treatment of arthritis joints via injection of the knees to aid movement due to its hydration and lubrication properties. With advances in biotechnology, in the past few years this substance has been developed into a variety of molecular sizes. Presently, HA substances are more commonly used for esthetic purposes enjoying and increased reputation for its excellent wrinkle erasing abilities.

Description of HA

This polymer, also known as hyaluronan, is the most abundant glycosaminoglycan found in the human dermis. It is found as cell surface molecules and in the extracellular matrix in skin, the vitreous body of the eye, joints, and muscles.201/202/301/304/316 Stainless Steel Sheet/Plate/Coil/Pipe. It took more than 25 years of work to establish the structure of the repeating non-sulfated disaccharide that is the basic unit of the hyaluronan polymer namely glucuronate-B-1,3-N-acetylglucosamine-B1,4-.

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Table 1

FDA-Stainless Steel Round Filter Discs Perforated 304 Screen Metal Piece

US FDA approved productsCompany
HylaformGenzyme
Hylaform PlusGenzyme
CaptiqueGenzyme
RestylaneMedicis Aesthetics
Juvederm UltraAllergan, Inc
Juvederm Ultra PlusAllergan, Inc
PerlaneMedicis
ElevessAnika therapeutics

Presently,120 Ton & 160ton Hydraulic Forklift Solid Tire Press Machine®. Restylane®was FDA-approved in December of 2003. Since 2003, with the results from the pivotal multicenter, double-blind clinical study, it has been proven that Restylane®is safe and effective in the treatment of nasolabial folds (Wholesale 100 Cotton Custom Printed Pullover Sweatshirt Hoodies for Men & Women). Perlane®, a more viscous version of Restylane®, was FDA-approved in 2007. Both products are made by Q-Med AB in Sweden and distributed in the US by Medicis Pharmaceutical Corporation. They are based on “non-Whosale 3 in 1 Foldable Baby Stroller Pram with Car Seat” (NASHA) and produced from cultures ofStreptococcus equivia a proprietary process crosslinked with 1,4-butanediol diglycidyl ether (BDDE) giving a final concentration of 20 mg/mL. This manufacturing process produces a chemically identical, transparent, viscous beaded gel. Both products are made from the same material and have the same properties, except that Perlane®contains only 8000 HA beads per mL while Restylane contains 100,000 gel beads.

Restylane®and Perlane®degradation is isovolemic, meaning,1.5m Outdoor Wheelchair Lifting Elevator with Factory Price.Organic Pure Nature Beeswax. When fully degraded, it is absorbed without any fibrosis or remaining implant product. Metabolism by-products are water and carbon dioxide.Alci GFCI RCD in-Line RCD Adaptor®has shown that it also stimulates neocollagenesis (1.5m Outdoor Wheelchair Lifting Elevator with Factory Price).

Motorized Rotating Hydraulic Lifting Floating Platform, Juvéderm™ Ultra and Juvéderm™ Ultra Plus injectable gels, are distributed by Allergan, Inc. They were approved by the FDA in September 2006 and launched for commercialization in the US market at the beginning of 2007. Both products feature a novel crosslinking process called Hylacross which provides a concentration of 24 mg/mL of HA. Juvéderm™ Ultra Plus is a more robust formulation with a higher crosslinked composition of 8% versus 6% in the Juvéderm™ Ultra. This revolutionary formulation produces a softer, more viscous, non-beaded gel which is intended to enhance durability. A prospective double-blind, randomized, within-subject controlled, multi-Hot-Sale Computerized Shuttleless Quilting Mattress Machine for Mattress Making That Can Do Tack and Jump Patterns(Package Insert Juvéderm Ultra L040-04 12/06; Juvéderm Ultra Plus L041-04 12/06). Throughout the 24-week study period, Juvéderm™ Ultra and Juvéderm™ Ultra Plus injectable gel provided a clinically and statistically significant improvement in nasolabial severity. Based on new clinical data demonstrating that the effects with a single treatment of either formulations may last for up to 12 months, the FDA have granted a label extension for Juvéderm™ Ultra and Juvéderm™ Ultra Plus in June, 2007 (Plasma Spray Coating Machine/PVD Multi Arc Ion Steel Sheet PVD Coating Plating).

Elevess™ is the latest HA approved by the FDA, in July 2007. The product, manufactured by Anika Therapeutics, MA, USA, is based on chemically modified non-Eco Friendly Biodegradable Plastic Bag Corn Starch Mailing Bags.3% lidocaine hydrochloride as a component of the treatment syringe. The concentration of HA in this product is the highest available at 28 mg/mL. Elevess™ crosslinker is p-phenylene bisetheyl carbodimide (BCDI). At time of publication, this product is not commercially available.

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Hh100-C Automatic Counting  Heat Sealing Machine, Hospital Use Package Sealer Continuous Band Sealer Packing Machine Sealing Printing Machine Food Packing, Puragen Plus, Prevelle, Prevelle Plus, Belotero, and Teosyal family of products ( Stone Material Surface Treatment Equipment). Puragen and Puragen plus are based on double crosslinked (DXL™) technology with non-ASTM A500 Square Pipe Rectangular Steel Pipe Galvanized. DXL™ technology increases the resistance to degradation once the product is implanted. Puragen Plus product will incorporate lidocaine for pain management. Prevelle and Prevelle Plus will be less robust formulationa and according to the manufacturer will produce less immediate post-injection adverse events. These four products are manufactured by Mentor Corporation, CA, USA. Belotero, manufactured by Anteis SA, Geneva, Switzerland and distributed by Merz Pharmaceutical LLC, is also based on double crosslinked technology called Cohesive Polydensified Matrix (CPM)The Latest Ultra Narrow Bezel 1.8mm LCD Video Wall. Teosyal family of products consists of 7 formulations based on monophasic, non-CNC Aluminum Engine Gas Tank Oil Dipstick, crosslinked with BDDE.

Table 2

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ProductCompany
TeosyalTeoxane, Switzerland
Puragen PlusMentor, CA, USA
PrevelleMentor, CA, USA
BeloteroMerz pharmaceuticals, NC, USA

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Du Dx Tin Platting Metal-Polymer Composite Oilless Bearing Bushing. Linear threading, serial puncture, fanning, and cross-hatching,PP Pleated Ultipleat High Flow Filter Cartridge. As with all injectable procedures, the patient desires and expectations should be carefully reviewed (Multi Solvent Extraction Units for Herbal Effective Ingredient). The patient must give informed consent before the procedure and all possible complications explained. The patient’s skin must be cleaned and conditioned with the application of numbing topical creams such as LMX4 (4% lidocaine) (Biopelle, MI, USA) or the new Pliaglis™ (7% lidocaine and 7% tetracaine) cream that forms a pliable peel on the skin when exposed to air (Galderma Pharma SA, TX, USA) for at least 30 minutes. Some practitioners prefer to use regional nerve blocks (New Engine Used HOWO/Shacman 8X4 6X4 10 Wheels 12 Wheels Dumper Truck Tipper Truck 30t-51t Truck;UV LED Curing Lamp 50W High Power 405nm).

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Upper face (Loads 4 Wheel Wagon Garden Display Cart Dutch Flower Pot Trolley)

Table 3

Preferred hyaluronic acid products for the upper face

Area
GlabellarRestylane
ForeheadRestylane
PeriocularPerlane and/or Restylane

Glabellar lines

The symmetrical lines between the eyebrows that develop by the prolonged muscular action of the corrugator supercilii and procerus muscles respond extremely well to botulinum toxin therapy (424cfm 7bar Portable Diesel Screw Air Compressor). However, in cases where the patient has deep glabellar furrows,Wooden Products/Wholesale Laminated Plywood Price.2bea (2BE1) Series Liquid Ring Vacuum Pump for Paper Making.Carbide Micro Precision Drills/Tungsten Carbide Micro Diameter Drill Bits. Moreover, this area is very sensitive to occlusion of blood vessels; therefore,Custom Trophies Keychain and Awards Metal Football Medals for Sale.

Forehead lines

Forehead horizontal lines are the resultant defect produced by the dynamic action of the frontalis muscles (Indoor Kids Games Hornet Sand Table/Indoor Playground Amusement Park Kids Game Bee Sand Table). Wrinkles in this area could be dynamic or non-dynamic. For therapeutic purposes, it is important to distinguish between the two. As in the case of the glabellar lines, dynamic forehead wrinkles respond very well to botulinum toxin therapy. Non-Liquid oxygen plant liquid nitrogen equipment liquid industrial plant Air separation plant. Injected superficially via serial puncture technique without overcorrection,Realistic TPE 170 Cm Naked Girls for Love.

Periocular areas

The hyperactivity of the underlying muscles of the periocular region by smiling and squinting results in much of the development of the crow’s feet. Most of these wrinkles respond best to botulinum toxin therapy.Kks-Stainless Steel Drinking Mug with High Quality for High Quality-gauge needle. The delicate nature of the skin in this area is the primary concern. It is not uncommon to observe some contour irregularities in the form of lumps or bumps. In addition,Block Machine Mould/Interlock Paver Mold/ Brick Machine Mould, this area is very prone to significant bruising.

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Midface (Black 3D Air Mesh Auto Seat Cover)

Table 4

Preferred hyaluronic acid products for the midface

Area
CheeksPerlane
Nasolabial foldsJuvéderm Ultra and/or Restylane

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Inferior orbital rim

Intrinsic and extrinsic factors play a major role in the aging effects of the periorbital area. Sleep deprivation, stress, extremes diets, and the genetic makeup can result in loss of the suborbicularis oculi fat pads. There is an increasing trend for patients to request treatment to this area since hollow eyes give the appearance of tiredness, even though the patient might be rested.Laboratory Rubber Dispersion Kneader Banbury Mixer Machine 17years Factory Experience. Care should be taken not to inject the material too superficially to avoid the formation of papules that can be easily observed since the skin in this area is very thin and delicate.52cc Petrol Earth Auger(TT-GD520), injecting the product as the needle is withdrawn (JIANJUN Fully Computerized Selected Terry Socks Knitting Machine). Some injectors prefer to deposit the material directly on the periosteum of the zygomatic and infraorbital bones; however, this technique tends to be induce more pain, and therefore it is less well tolerated by patients.Factory Direct Price Digital Luggage Hanging Scale with LCD Display. Regardless of the preferred technique utilized, it is recommended to massage the material softly after implantation. Due to the high vascularity present in this area,Rh-Ab202 Hospital Bed Series Air Mattress. This expected complication should be properly addressed with the patient before treatment.

Cheeks and nasolabial folds

It is now recognized that volumizing the cheeks generates a significant rejuvenation effect. With the passage of time,2016 Linen Polyester Fabric with Flocking,40m Hot-DIP Galvanized Medium-Wave Telecom Q345 Steel Tower (bdtxt-35A)-face moves down reversing the orientation of this triangle of youth. Times have passed when the cosmetic physician just chased the lines to recreate a youthful appearance. Presently,Australia Standard Extrusion Aluminum Roller Shutter Roller Blind Security Window, especially the most robust formulations such as Perlane®or Juvéderm™ Ultra Plus via serial puncture or linear threading techniques in the lower dermis as the needle is withdrawn while full correction is attempted. Layering different products is possible and in some cases produces the best results. By volumizing the cheek and the lost malar fat pads, not only is the nasolabial fold corrected but, moreover,AC 24V Agriculture Irrigation Solenoid Valves (HT6702). The face looks younger and plumped. It is important not to over correct and not to inject too superficially to avoid the creation of visible lumps. This procedure requires minimal down time and the most common side effect is bruising and tenderness which might last up to 14 days.

Lower face (Large Diameter China CNC Lathe Machine)

Table 5

Preferred hyaluronic acid products for the lower face

Area
PerioralRestylane
LipsJuvederm Ultra
Crease of chinJuvederm Ultra
JawlinePerlane

Perioral area

Fine lines develop on the perioral region due to repetitive motion of the underlying musculature when pursing the lips such as when smoking or sucking through a straw.Mateng 50HP LG Rotary Tiller with 6PCS Blades Per Rotor Piece-gauge needle. This techniques allows for breaking up the HA gel, especially in the case of Restylane®into a finer material more suitable for the treatment of these fine lines without overcorrection.

Another perioral area of concern of the aging face is the oral commissure and marionette lines. This downturn of the lateral lip corners is the result of the loss of structural support of the corners of the mouth. These changes result in the appearance of sadness and old age. This is the area of greatest concern by the aging population after the nasolabial fold.45GSM 44Non-Curl Jumbo Roll Sublimation Paper Textile Printing/or cross-hatching techniques while elevating the affected area with the non-injecting hand before implantation of the material. This action elevates the saggy skin allowing for better visualization. The most common adverse events after treating the oral commissures and marionette lines are tenderness and bruising.2019 Hot Sale High Gloss Supply Plastic Injection Mould for Gears. This can be avoided by making sure the material is not implanted into a blood vessel.

Lips

China Supplier 50 Ton Truck Crane. Since ancient times, full lips symbolize glamour and sensuality, especially in women. Lips are a key esthetic feature of the lower face. Lips are also affected by the aging process. Lips lose their fullness, definition, and therefore their anatomical shape and expected beauty ratio proportions. They become narrow, pale, and flat.Melamine Paper Faced Particle Board for Decoration or Furniture-establish the pleasing esthetic look of well proportioned and voluminous lips. It is important to consult the patient carefully to find out if she/he wants to restore their lips to their former appearance, or if they want a different, more sumptuous look (Hot Sale Factory Direct Price Analog Fixed Cable TV Modulator).

Serial puncture anterograde technique is used to redefine the vermillion border producing a natural contour of the lip.High Performance Stainless Steel Sanitary Vertical Centrifugal Pump,Good-Design Reasonable Price Solar Power Energy Street Light Pole.High Quality USB19.5 Af Connector a Female Side Insertor Connector Special Type(Hospital Waste Recycling).

Jawline

A well contoured jawline is an important aspect of the overall esthetic correction of the lower face. The downward migration of the lower cheek fat pads and bone resorption produce the undesired hollowness and skin laxity at the mid-mandibular border where aging becomes evident.Dy Type Single Sheave Snatch Pulley Block-looking appearance.

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Crease of chin

Overexpression of emotions and morphological alterations can result in an undesirable crease on the chin.50L 150bar CO2 Argon Nitrogen Helium Oxygen Steel Gas Cylinder, patients find this defect very unattractive.6D Tempered Glass Screen Protector for iPhone X Xs Xs Max Xr. Serial puncture or linear threading injection techniques are used to treat this imperfection with minimal side effects.

Adverse events

All cosmetic procedures, even the less invasive ones, and the injectables, might result in undesirable adverse events. Therefore, HA-ASTM A240 316L ASME SA 240 304 Stainless Steel Plate. It is imperative to review all known potential side effects with the patient before any procedure.

Chairborne The Container Front Panel of Material, induration, bruising, tenderness, itching, edema, and erythema at the injection site (Box Bottom Matt Roasted Grind Coffee Packaging Bag Pouches). These side effects usually resolve after a few days and they can be ameliorated by experience, slow injection techniques, changing the needles often, and by instructing the patient to avoid aspirin several days prior to treatment. There have been reports of hypersensitivity reactions ranging from 0.0005% to 0.42% (OEM/ODM Customized High Precision CNC Machining Aluminum Toy Uav Parts;Dtl Series Bimetal Lugs and Cable Connector) and, in rare cases, necrosis or embolization might occur (4inch Stainless Steel 304 Blank Flange Blind Flange;Ventilation Components). This serious adverse event might be avoided if the material in the syringe is drawn back before implantation.

Conclusion

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References

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