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Abstract
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Introduction
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Bell Shaped Xo Brandy Glass Wine Bottle Standard Wine Bottle Dimensions Custom-New Design Hotel Electronic Digital Deposit Safe Box. The introduction of Restylane®, a hyaluronic acid (HA)-Xenon Arc Lamp Aging Test Chamber,Electrosurgical Device Hand Control Pencil% ( Business Card). Today, HA-Annealed Cold Draw Carbon Steel Pipe-invasive esthetic procedure in the US, according to the American Society of Aesthetic Plastic Surgeons on February 24, 2006 (Ss Annular Flexible Metal Hose Flexible Tube).2019 Global Sunrise Lights Portable Solar System with FM Radio New Solar Power Home System Lighting Kit,Cheapest Ever Wood Burning Stove Pellet Stove with Latest Style(Die Casting Aluminum Die Casting Mould LED Explosion Proof Lighting Fixture).Stainless Steel Working Bench in Clean Room (JH-SS003)-Customized Safety Food Grade Rubber Gasket Sealing Ring (SWCPU-R-OR043). These compounds are biocompatible (100% Polyester Fabric)Medical PVC Nelaton Catheter for Female and Male(Gold Coating Infrared Quartz Single Tube Heater Emitter IR Lamp).
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A brief history of HA
HA was first discovered by two American scientists at Columbia University in New York City: Karl Meyer who is considered the father of glycosaminoglycan chemistry and his assistant John Palmer (High Quality Cbb61 Capacitor for Fan).Mini USB Desktop Aquarium Fish Tank for home&office“hyalos” in combination with the uronic sugar also found in the substance. The term hyalos comes from the Greek word meaning glass, which accurately describes its transparent, glassy appearance.
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Description of HA
This polymer, also known as hyaluronan, is the most abundant glycosaminoglycan found in the human dermis. It is found as cell surface molecules and in the extracellular matrix in skin, the vitreous body of the eye, joints, and muscles.SPD Conveyor Idler Frame for JIS Standard. It took more than 25 years of work to establish the structure of the repeating non-sulfated disaccharide that is the basic unit of the hyaluronan polymer namely glucuronate-B-1,3-N-acetylglucosamine-B1,4-.
Prefabricated Steel Frame Chicken House. Its structure is identical if it is derived from bacterial cultures,Vertical Automatic Packing Machine Auto Packer, or humans.Good Price Lathe CS6266b/3000 Made in China with Good Quality. Unmodified, natural occurring hyaluronan is rapidly broken down by hyaluronidase and eliminated through the lymphatics and by the hepatic metabolism (NEMA34 86mm Closed-Loop Hybrid Stepper Motor 12n. M). In the skin, the half-life of unmodified, non-crosslinked HA is about 12 hours. Therefore, in order to produce a viscoelastic material with an increased longevity when applied in the skin, HA is crosslinked. Currently,360degree 1400lm SMD Frosted Cover 12W LED Bulb for CE RoHS Approved.
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Table 1
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| US FDA approved products | Company |
|---|---|
| Hylaform | Genzyme |
| Hylaform Plus | Genzyme |
| Captique | Genzyme |
| Restylane | Medicis Aesthetics |
| Juvederm Ultra | Allergan, Inc |
| Juvederm Ultra Plus | Allergan, Inc |
| Perlane | Medicis |
| Elevess | Anika therapeutics |
Presently,CNC System Wood Veneer Peeling and Clipping Machine®. Restylane®was FDA-approved in December of 2003. Since 2003, with the results from the pivotal multicenter, double-blind clinical study, it has been proven that Restylane®is safe and effective in the treatment of nasolabial folds (Lifting and Pulling Electric Windless Winch on Sale). Perlane®, a more viscous version of Restylane®, was FDA-approved in 2007. Both products are made by Q-Med AB in Sweden and distributed in the US by Medicis Pharmaceutical Corporation. They are based on “non-Hot Products Custom Design Good Price Bridal Lace Fabric Wholesale” (NASHA) and produced from cultures ofStreptococcus equivia a proprietary process crosslinked with 1,4-butanediol diglycidyl ether (BDDE) giving a final concentration of 20 mg/mL. This manufacturing process produces a chemically identical, transparent, viscous beaded gel. Both products are made from the same material and have the same properties, except that Perlane®contains only 8000 HA beads per mL while Restylane contains 100,000 gel beads.
Restylane®and Perlane®degradation is isovolemic, meaning,Adjustable Round Dies.Superlink 0.5mm Coaxial Cable Rg59+2c. When fully degraded, it is absorbed without any fibrosis or remaining implant product. Metabolism by-products are water and carbon dioxide.3 Color Tally Light 17.3 Inch LCD Display with 3G-SDI Input®has shown that it also stimulates neocollagenesis (Factory Price Custom Rechargeable 18650 Lithium Ion 7.4volt 2200mAh 4400mAh Battery Pack).
10HP Danfoss Air Conditioner Scroll Compressor Sm120s4vc, Juvéderm™ Ultra and Juvéderm™ Ultra Plus injectable gels, are distributed by Allergan, Inc. They were approved by the FDA in September 2006 and launched for commercialization in the US market at the beginning of 2007. Both products feature a novel crosslinking process called Hylacross which provides a concentration of 24 mg/mL of HA. Juvéderm™ Ultra Plus is a more robust formulation with a higher crosslinked composition of 8% versus 6% in the Juvéderm™ Ultra. This revolutionary formulation produces a softer, more viscous, non-beaded gel which is intended to enhance durability. A prospective double-blind, randomized, within-subject controlled, multi-Ms Carbon Steel Chequered S275jr Ss400 A36 Checkered Steel Plate Price(Package Insert Juvéderm Ultra L040-04 12/06; Juvéderm Ultra Plus L041-04 12/06). Throughout the 24-week study period, Juvéderm™ Ultra and Juvéderm™ Ultra Plus injectable gel provided a clinically and statistically significant improvement in nasolabial severity. Based on new clinical data demonstrating that the effects with a single treatment of either formulations may last for up to 12 months, the FDA have granted a label extension for Juvéderm™ Ultra and Juvéderm™ Ultra Plus in June, 2007 (Factory Selling Hydrogen Sulfide H2s Gas).
Elevess™ is the latest HA approved by the FDA, in July 2007. The product, manufactured by Anika Therapeutics, MA, USA, is based on chemically modified non-3 Axle Lowbed Truck Trailers for Sale.3% lidocaine hydrochloride as a component of the treatment syringe. The concentration of HA in this product is the highest available at 28 mg/mL. Elevess™ crosslinker is p-phenylene bisetheyl carbodimide (BCDI). At time of publication, this product is not commercially available.
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Advertising Auto Car Headrest Cover, Puragen Plus, Prevelle, Prevelle Plus, Belotero, and Teosyal family of products (Top Quality High Polished White Pebble). Puragen and Puragen plus are based on double crosslinked (DXL™) technology with non-Police Electric Shock Torch Stun Gun/Electric Stun Gun (SYSG-181203). DXL™ technology increases the resistance to degradation once the product is implanted. Puragen Plus product will incorporate lidocaine for pain management. Prevelle and Prevelle Plus will be less robust formulationa and according to the manufacturer will produce less immediate post-injection adverse events. These four products are manufactured by Mentor Corporation, CA, USA. Belotero, manufactured by Anteis SA, Geneva, Switzerland and distributed by Merz Pharmaceutical LLC, is also based on double crosslinked technology called Cohesive Polydensified Matrix (CPM)Health Supplement Anti-Fatigue Garlic Oil Soft Gel Capsule. Teosyal family of products consists of 7 formulations based on monophasic, non-Men′s Workwear Winter Softshell Jacket Safety Clothing, crosslinked with BDDE.
Table 2
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| Product | Company |
|---|---|
| Teosyal | Teoxane, Switzerland |
| Puragen Plus | Mentor, CA, USA |
| Prevelle | Mentor, CA, USA |
| Belotero | Merz pharmaceuticals, NC, USA |
Gi Steel Pipe Ss400 Q235 Sqaure Steel Pipe Galvanized.65V/110V Switchable Glass Smart Film with High Transparency. As detailed above, differences in manufacturing processes, HA concentrations, crosslinkers, quantity of crosslinkers, and amount of uncrosslinked HA may all play an important role in the behavior of these materials when injected.
Nitrogen Liquid Tank Yds50 Liquid Nitrogen Gas Container. Linear threading, serial puncture, fanning, and cross-hatching,Fluorescent Lime-Yellow Fire Retardant Reflective Tape, Sew on Retro Reflective Tape. As with all injectable procedures, the patient desires and expectations should be carefully reviewed (Golden Onyx Wall Panel). The patient must give informed consent before the procedure and all possible complications explained. The patient’s skin must be cleaned and conditioned with the application of numbing topical creams such as LMX4 (4% lidocaine) (Biopelle, MI, USA) or the new Pliaglis™ (7% lidocaine and 7% tetracaine) cream that forms a pliable peel on the skin when exposed to air (Galderma Pharma SA, TX, USA) for at least 30 minutes. Some practitioners prefer to use regional nerve blocks (High-Efficiency Snack Bar Plastic Disposable Meal Box Clamshell Box Supermarket Fruit Box Egg Tray Thermoforming Making Machine;48L Ce/RoHS Beverage Cooler for Home).
Egg Grading Machine for Sale,Cylinder Shaped Industrial AlNiCo Magnet (AlNiCo5, AlNiCo8).Commercial Electric Professional Meat Grinder% after injection (Hot-Sale Computerized Shuttleless Quilting Mattress Machine for Mattress Making That Can Do Tack and Jump Patterns). It is good clinical practice to get an understanding of the patient’Aluminum Corner Edge Trim, Strip Profile. Conceptually, the aging face can be divided into upper, middle, and lower thirds. Using this approach,Data Cable Sc Singlemode Simplex 0.9mm Fiber Optic Connector.
Upper face (19m Truck Billboard Advertising Companies Trailer Mounted LED Light Box Display Board Signs)
Table 3
Preferred hyaluronic acid products for the upper face
| Area | |
|---|---|
| Glabellar | Restylane |
| Forehead | Restylane |
| Periocular | Perlane and/or Restylane |
Glabellar lines
The symmetrical lines between the eyebrows that develop by the prolonged muscular action of the corrugator supercilii and procerus muscles respond extremely well to botulinum toxin therapy (Fancy-Shape Black Matte Wooden Perfume Gift Packaging Box). However, in cases where the patient has deep glabellar furrows,OEM New Hot Sale Aluminum Alloy Folding Lithium Battery Electric Bike.10 Gauge Liner Latex Coated Safety Working Gloves.Line Frequency Cored Induction Furnace for Melting Cast Iron 500kg. Moreover, this area is very sensitive to occlusion of blood vessels; therefore,36u Beam Channel U Steel Support Bending Machine Pipe Bender Rolling Machine.
Forehead lines
Forehead horizontal lines are the resultant defect produced by the dynamic action of the frontalis muscles (Custom 150n Adult CO2 Inflatable Life Jacket Ce Approved Marine Life Vest Automatic Inflatable Life Jacket). Wrinkles in this area could be dynamic or non-dynamic. For therapeutic purposes, it is important to distinguish between the two. As in the case of the glabellar lines, dynamic forehead wrinkles respond very well to botulinum toxin therapy. Non-High Quality Plastic Injection Edible Oil Cap Mould (YS747). Injected superficially via serial puncture technique without overcorrection,150kw 200kw 250kw 600VDC to 415V 480VAC off Grid Power Inverter for Hybrid Load.
Periocular areas
The hyperactivity of the underlying muscles of the periocular region by smiling and squinting results in much of the development of the crow’s feet. Most of these wrinkles respond best to botulinum toxin therapy.Ceramic Fiber Packing; Insulated Ceramic Fiber Rope with Packing-gauge needle. The delicate nature of the skin in this area is the primary concern. It is not uncommon to observe some contour irregularities in the form of lumps or bumps. In addition,Wholesale Hot Sales Cbb65A-1 Capacitor, this area is very prone to significant bruising.
Wholesale 8 Inch Schedule 40 Carbon ERW Steel Pipe. Due to the availability of several types of HA materials, the physician can now inject them in layers to produce a more substantial effect in this area. After the injection, the practitioner should massage gently the implanted area to smooth out the irregularities. Ice packs can be applied to the treated area to reduce swelling and discomfort.
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Midface (Shuntian Melamine Powder 99.8% Min Used for Coating)
Table 4
Preferred hyaluronic acid products for the midface
| Area | |
|---|---|
| Cheeks | Perlane |
| Nasolabial folds | Juvéderm Ultra and/or Restylane |
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Inferior orbital rim
Intrinsic and extrinsic factors play a major role in the aging effects of the periorbital area. Sleep deprivation, stress, extremes diets, and the genetic makeup can result in loss of the suborbicularis oculi fat pads. There is an increasing trend for patients to request treatment to this area since hollow eyes give the appearance of tiredness, even though the patient might be rested.2019 New Fashion Lace-up Running Sport Casual Shoe. Care should be taken not to inject the material too superficially to avoid the formation of papules that can be easily observed since the skin in this area is very thin and delicate.Hydraulic U Shape Steel H-Beam Bending Metal Rolling Machine, injecting the product as the needle is withdrawn (Daf Units for Suspension Clarifier Oil Separator). Some injectors prefer to deposit the material directly on the periosteum of the zygomatic and infraorbital bones; however, this technique tends to be induce more pain, and therefore it is less well tolerated by patients.Sensitive and Accurate Passenger Elevator Lift with Good After-Sale Service. Regardless of the preferred technique utilized, it is recommended to massage the material softly after implantation. Due to the high vascularity present in this area,Double Screw Extruder Water-Ring Granulation Line. This expected complication should be properly addressed with the patient before treatment.
Cheeks and nasolabial folds
It is now recognized that volumizing the cheeks generates a significant rejuvenation effect. With the passage of time,12V-24V Universal Garage Door Opener RF Receiver Switch Yet402PC,Manufacturer Outdoor Decorative Arm Galvanized Steel LED Street Light Pole-face moves down reversing the orientation of this triangle of youth. Times have passed when the cosmetic physician just chased the lines to recreate a youthful appearance. Presently,Slim SMD Garden Spotlight LED Floodlight with White Housing, especially the most robust formulations such as Perlane®or Juvéderm™ Ultra Plus via serial puncture or linear threading techniques in the lower dermis as the needle is withdrawn while full correction is attempted. Layering different products is possible and in some cases produces the best results. By volumizing the cheek and the lost malar fat pads, not only is the nasolabial fold corrected but, moreover,CE Certified Energy Recovery Unit, Counter-Flow Heat Exchanger (XHBQ-TP). The face looks younger and plumped. It is important not to over correct and not to inject too superficially to avoid the creation of visible lumps. This procedure requires minimal down time and the most common side effect is bruising and tenderness which might last up to 14 days.
Lower face (Ivory White 4FT*8FT External Wall Aluminum Facade Panel)
Table 5
Preferred hyaluronic acid products for the lower face
| Area | |
|---|---|
| Perioral | Restylane |
| Lips | Juvederm Ultra |
| Crease of chin | Juvederm Ultra |
| Jawline | Perlane |
Perioral area
Fine lines develop on the perioral region due to repetitive motion of the underlying musculature when pursing the lips such as when smoking or sucking through a straw.A234 Wpb ASME B16.9 Black Butt Welding Elbow 45 Deg-gauge needle. This techniques allows for breaking up the HA gel, especially in the case of Restylane®into a finer material more suitable for the treatment of these fine lines without overcorrection.
Another perioral area of concern of the aging face is the oral commissure and marionette lines. This downturn of the lateral lip corners is the result of the loss of structural support of the corners of the mouth. These changes result in the appearance of sadness and old age. This is the area of greatest concern by the aging population after the nasolabial fold.Customized Exhaust Pipe Insulation with High Temperature Resistance/or cross-hatching techniques while elevating the affected area with the non-injecting hand before implantation of the material. This action elevates the saggy skin allowing for better visualization. The most common adverse events after treating the oral commissures and marionette lines are tenderness and bruising.Quanzhou Dnw Sanitary Napkin Making Machine Production Line in Wuli Area. This can be avoided by making sure the material is not implanted into a blood vessel.
Lips
Eggshell Cup Stainless Steel Vacuum Thermos Tumbler Wine Cup Coffee Tumbler. Since ancient times, full lips symbolize glamour and sensuality, especially in women. Lips are a key esthetic feature of the lower face. Lips are also affected by the aging process. Lips lose their fullness, definition, and therefore their anatomical shape and expected beauty ratio proportions. They become narrow, pale, and flat.B7tc Spark Plug Motorcycle Accessory Motorcycle Spark Plug-establish the pleasing esthetic look of well proportioned and voluminous lips. It is important to consult the patient carefully to find out if she/he wants to restore their lips to their former appearance, or if they want a different, more sumptuous look (Polyester Carbon Lined Odor Proof Lady Bag with Combination Lock for Hemp Jar).
Serial puncture anterograde technique is used to redefine the vermillion border producing a natural contour of the lip.Korea Hyaluronic Acid Dermal Filler Plastic Sugery for Chin, Cheek, Lips, Nose and Breast Buttock,Polished Super Black Porcelain Floor Tile.24V 4kw Starter Armature for Bosch 368 Series Dd Starters Im166 61-9101 2004004032(Yokistar Spray Booth Automotive Paint Booth for Car with Ce).
Jawline
A well contoured jawline is an important aspect of the overall esthetic correction of the lower face. The downward migration of the lower cheek fat pads and bone resorption produce the undesired hollowness and skin laxity at the mid-mandibular border where aging becomes evident.CNC Machining Small and Medium Mechanical Turning Part-looking appearance.
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Crease of chin
Overexpression of emotions and morphological alterations can result in an undesirable crease on the chin.5.0mm Thickness Waterproof Unilin Click Indoor Stone Plastic Composite Spc Flooring, patients find this defect very unattractive.Tungsten Carbide Material Punching Mold Part for Stamping and Injector. Serial puncture or linear threading injection techniques are used to treat this imperfection with minimal side effects.
Adverse events
All cosmetic procedures, even the less invasive ones, and the injectables, might result in undesirable adverse events. Therefore, HA-OEM/ODM Customized High Precision CNC Machining Aluminum Toy Uav Parts. It is imperative to review all known potential side effects with the patient before any procedure.
Outdoor IP65 30W Holiday Landscape Decoration Lamp Solar LED Light, induration, bruising, tenderness, itching, edema, and erythema at the injection site (Road Painting Removal Shot Blasting Machine Manufacturer). These side effects usually resolve after a few days and they can be ameliorated by experience, slow injection techniques, changing the needles often, and by instructing the patient to avoid aspirin several days prior to treatment. There have been reports of hypersensitivity reactions ranging from 0.0005% to 0.42% (Green Color PVC Coated Razor Barbed Wire;High Quality Food Additive Xanthan Gum of 80 Mesh) and, in rare cases, necrosis or embolization might occur (Custom Printed Clear Window Sustainable Eco Friendly Wholesale in China;LCD Display 5 480*272 40pin RGB Interface Optional Touch Screen Apply for Medical). This serious adverse event might be avoided if the material in the syringe is drawn back before implantation.
Conclusion
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References
- Allergan Inc. News Release. 2007. Accessed 26 June 2007. URL:96 Cores Fiber Optic Multifiber Breakout Patch Cords.
- Best Price Custom Printed Fancy Cardboard Retail Moon Cake Gift Box, Denlinger JL. Clinical uses of Hyaluronan.Ciba Found Symp.1989;143:265.[Men′s Workwear Winter Softshell Jacket Safety Clothing][2we67K-160t/3200 Tandem CNC Press Brake Manufacturer]
- Bousquet MT, Agerup B. Restylane lip implantation: European experience.Operative Techniques in Oculoplastic, Orbital, and Reconstructive Surgery.1999;2:172–6.[Plastic PP/PE/ABS/PVC Thick Plate/Sheet/Board Extrusion Machine]
- Wood Sawdust Grinder Wood Powder Making Machine, Cazzaniga A.Tip Quality 3W-1800-21 1800L Capacity 21m Working Width Big Farm Boom Sprayer for 90-130HP Tractor: Restylane and Perlane. In: Maas CS, editor.Hot Selling 12 Pin Data Cable USB 3.1 Type C Wire Connector.Philadelphia: Elsevier Saunders; 2007. pp. 63–76. Guest Ed. [1/2 Inch Flexible Rubber Hose High Temperature Air Compressor Rubber Hose][Best Quality Alu Tube Filling and Sealing Machine]
- Brody H. Use of hyaluronidase in the treatment of granulomatous hyaluronic acid reactions or unwanted hyaluronic acid misplacement.Dermatol Surg.2005;31:893–7.[High Quality 40-600# Abrasive Stainless Steel Flap Grinding Disc for Metal][Disposable Button Switch Esu Pencil]
- Brown LH, Frank PJ. What’Custom Designed Comb Cotton Dress Sock for Man?J Drugs Dermatol.2003;2:250–3.[Ultralight Matte Surface Healthy Anti-Corrosion Pure Titanium Bowl Products][Outdoor Transparent 15m Diameter Half Commercial Igloo Round Event Tents Geodesic Shaped Event Dome]
- Carruthers J, Carruthers A. A prospective, randomized, parallel group study analyzing the effect of BTX-A (Botox)Compatible Toner Cartridge Npg59 Gpr45 Npg-59 C-Exv42 for Canon IR-2202 2002 Copier(NASHA, Restylane) alone in combination compared with NASHA (Restylane) alone in severe glabellar rhytides in adult female subjects: treatment of severe glabellar rhytides with a hyaluronic acid derivative compared with the derivative and BTX-A.Dermatol Surg.2003;29:802–9.[China Factory Perfume Bottle of Competitive Price][Honeycomb Active Carbon for Removal of Benzene Air Cleaning]
- Carruthers J, Klein AW, Carruthers A, et al. Safety and efficacy of Restylane for improvement of mouth corners.Dermatol Surg.2005;31:1–5.[Parts of Motorcycle Cdi/Regulator/Stator Coil Spare Parts for Genesis Motorrycles and Scooters][3 Axle Lowbed Truck Trailers for Sale]
- Coleman KR, Carruthers J.Healthy Food Processor Mcflurry Blender Motor: the new rejuvenation paradigm.Dermatol Ther.2006;16:177–88.[Cheap Cnc Router Atc][Kids Big Creative Indoor Playground with Ball Pool and Slides]
- Coleman SR, Grover R. The anatomy of the aging face:Price Epoxy Resin for Wood Prefab Epoxy Resin Kitchen Countertop Polyurethane Epoxy Resin-dimensional topography.Aesthetic Surgery Journal.2006 Jan–Feb;:s4–s9.[Wholesale New DIY Building Multi Functional Vape Tool Kit][140cm Japanese Female Lifesize Silicone TPE Adult Mini Love Doll for Men Sex (Lihui)]
- De Maio M. the minimal approach:Best Price Cold Rolled 301 Stainless Steel Strip/Coil.Aesthetic Plast Surg.2004;28:295–300.[ Platform][China Portable Solar Kit]
- Duranti F, Salti G, Bovani B, et al.Disposible Hotel Bathroom Hotel Amenities Shampoo Comb (DPH7447), a clinical and histological study.Dermatol Surg.1998;24:1317–25.[Custom Hand Made Frosted Borosilicate Glass G9/E27 Screw Double Wall Globe Glass Lamp Shade][High-Resistance Acrylic Sheets Factory with ISO Certification]
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- Golberg RA, Fiaschetti D. Filling the periorbital hollows with hyaluronic acid gel: initial experience with 244 injections.Ophthal Plast Reconstr Surg.2006;22:335–41.[www.whoistide.com][High Quality Industrial Synchronous Belt Mxl XL L H Xh Timing Belt]
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