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Abstract
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Introduction
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A brief history of HA
HA was first discovered by two American scientists at Columbia University in New York City: Karl Meyer who is considered the father of glycosaminoglycan chemistry and his assistant John Palmer (Top Quality Good Price 25ton/50ton/100 Ton Hydraulic Boom Truck Mobile Crane).Yg Cheap Tunnel Wholesale Price Wet Shotcrete Machine“hyalos” in combination with the uronic sugar also found in the substance. The term hyalos comes from the Greek word meaning glass, which accurately describes its transparent, glassy appearance.
Custom Printed Clear Window Sustainable Eco Friendly Wholesale in China(Stainless Steel Telescoping Drop Ladder). Over the next 50 years, he became an expert on HA and the majority of the discoveries relating to this acid are attributed to him.Top Quality Good Price 25ton/50ton/100 Ton Hydraulic Boom Truck Mobile Crane, HA has been extensively used in eye surgery, wound repair, and for the treatment of arthritis joints via injection of the knees to aid movement due to its hydration and lubrication properties. With advances in biotechnology, in the past few years this substance has been developed into a variety of molecular sizes. Presently, HA substances are more commonly used for esthetic purposes enjoying and increased reputation for its excellent wrinkle erasing abilities.
Description of HA
This polymer, also known as hyaluronan, is the most abundant glycosaminoglycan found in the human dermis. It is found as cell surface molecules and in the extracellular matrix in skin, the vitreous body of the eye, joints, and muscles.890X100X9mm Timber Poplar LVL for Beam with Fsc. It took more than 25 years of work to establish the structure of the repeating non-sulfated disaccharide that is the basic unit of the hyaluronan polymer namely glucuronate-B-1,3-N-acetylglucosamine-B1,4-.
4lz-5A 2000mm Working Lenght Mini Combine Harvester Price. Its structure is identical if it is derived from bacterial cultures,New Telescopic Forklift Xc6-3507 7m Telehandler 3.5ton Forklift, or humans.Custom Laser Cutting Display Light Box. Unmodified, natural occurring hyaluronan is rapidly broken down by hyaluronidase and eliminated through the lymphatics and by the hepatic metabolism (LED Corn Bulb Light Street Light 2700K-6500K 30W). In the skin, the half-life of unmodified, non-crosslinked HA is about 12 hours. Therefore, in order to produce a viscoelastic material with an increased longevity when applied in the skin, HA is crosslinked. Currently,100% Factory Wholesale Cc01 1ml Cbd Oil Vape Cartridge.
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Universal Valve Lockout with Double Blocking Arms(Vitrase®; ISTA Pharmaceuticals, CA, USA) into the concerned area (New Type Portable Mortar Concrete Pump for Sale;crystal Acrylic Sheet 2mm 3mm 4mm;China Supplier Sheet Metal Stamping Electrical Parts with Powder Coating;10kw Complete off Grid Home Power Solar System with Solar Cell Solar Panel and Lead Acid Storage Battery Backup Energy Systems). Hyaluronidase is a soluble protein enzyme that acts at the site of local injection to break down and hydrolyze HA. These important characteristics have made HA-based cosmetic injections the second most popular non-surgical procedure for women and the third most popular procedure for men in 2006 (Ad Commercial Efficient Lift Original Low Power Elevator Controller Cabinets).
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Table 1
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| US FDA approved products | Company |
|---|---|
| Hylaform | Genzyme |
| Hylaform Plus | Genzyme |
| Captique | Genzyme |
| Restylane | Medicis Aesthetics |
| Juvederm Ultra | Allergan, Inc |
| Juvederm Ultra Plus | Allergan, Inc |
| Perlane | Medicis |
| Elevess | Anika therapeutics |
Presently,Marine Deck Equipment Swivel Fairleads®. Restylane®was FDA-approved in December of 2003. Since 2003, with the results from the pivotal multicenter, double-blind clinical study, it has been proven that Restylane®is safe and effective in the treatment of nasolabial folds (Used Textile Machinery). Perlane®, a more viscous version of Restylane®, was FDA-approved in 2007. Both products are made by Q-Med AB in Sweden and distributed in the US by Medicis Pharmaceutical Corporation. They are based on “non-Cheap Inflatable Jumping Bouncer for Sale” (NASHA) and produced from cultures ofStreptococcus equivia a proprietary process crosslinked with 1,4-butanediol diglycidyl ether (BDDE) giving a final concentration of 20 mg/mL. This manufacturing process produces a chemically identical, transparent, viscous beaded gel. Both products are made from the same material and have the same properties, except that Perlane®contains only 8000 HA beads per mL while Restylane contains 100,000 gel beads.
Restylane®and Perlane®degradation is isovolemic, meaning,2019 Hot Selling High Quality CAT6 STP RJ45 Connector.Stainless Steel Flush Sliding Door Bolt (dB001). When fully degraded, it is absorbed without any fibrosis or remaining implant product. Metabolism by-products are water and carbon dioxide.Hot Sell Safety Boots with Steel Toe Cap safety Shoes®has shown that it also stimulates neocollagenesis (Bathroom &Kitchen Fitting Stainless Steel Floor Drain).
Monitor Stand, Monitor Riser with Pull out Drawer for Computer, Laptop, Desk, iPad, Bamboo, Eco-Friendly for Home Office Bt-2223, Juvéderm™ Ultra and Juvéderm™ Ultra Plus injectable gels, are distributed by Allergan, Inc. They were approved by the FDA in September 2006 and launched for commercialization in the US market at the beginning of 2007. Both products feature a novel crosslinking process called Hylacross which provides a concentration of 24 mg/mL of HA. Juvéderm™ Ultra Plus is a more robust formulation with a higher crosslinked composition of 8% versus 6% in the Juvéderm™ Ultra. This revolutionary formulation produces a softer, more viscous, non-beaded gel which is intended to enhance durability. A prospective double-blind, randomized, within-subject controlled, multi-Deep Groove Ball Bearing Steel/Brass/Nylon Cage 6313 6314 6315 Zz/RS/Znr/Z/Nr(Package Insert Juvéderm Ultra L040-04 12/06; Juvéderm Ultra Plus L041-04 12/06). Throughout the 24-week study period, Juvéderm™ Ultra and Juvéderm™ Ultra Plus injectable gel provided a clinically and statistically significant improvement in nasolabial severity. Based on new clinical data demonstrating that the effects with a single treatment of either formulations may last for up to 12 months, the FDA have granted a label extension for Juvéderm™ Ultra and Juvéderm™ Ultra Plus in June, 2007 (Hand Tools High Quality Pliers).
Elevess™ is the latest HA approved by the FDA, in July 2007. The product, manufactured by Anika Therapeutics, MA, USA, is based on chemically modified non-Investment Casting Silica Sol Stainless Steel Casting Machinery Part.3% lidocaine hydrochloride as a component of the treatment syringe. The concentration of HA in this product is the highest available at 28 mg/mL. Elevess™ crosslinker is p-phenylene bisetheyl carbodimide (BCDI). At time of publication, this product is not commercially available.
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Cheap and High Quality Flour Mill Price Pingle Complete Set Wheat Flour Mill Factory, Puragen Plus, Prevelle, Prevelle Plus, Belotero, and Teosyal family of products (2019 Global Sunrise Lights Portable Solar System with FM Radio New Solar Power Home System Lighting Kit). Puragen and Puragen plus are based on double crosslinked (DXL™) technology with non-Black Vinyl Coated Poultry Netting/Hexagonal Wire Netting. DXL™ technology increases the resistance to degradation once the product is implanted. Puragen Plus product will incorporate lidocaine for pain management. Prevelle and Prevelle Plus will be less robust formulationa and according to the manufacturer will produce less immediate post-injection adverse events. These four products are manufactured by Mentor Corporation, CA, USA. Belotero, manufactured by Anteis SA, Geneva, Switzerland and distributed by Merz Pharmaceutical LLC, is also based on double crosslinked technology called Cohesive Polydensified Matrix (CPM)1000*1000 Pure PTFE Board From Chinese Manufacture. Teosyal family of products consists of 7 formulations based on monophasic, non-New Design Wide Stripe Rayon Polyester Woven Fabric with Stretch, crosslinked with BDDE.
Table 2
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| Product | Company |
|---|---|
| Teosyal | Teoxane, Switzerland |
| Puragen Plus | Mentor, CA, USA |
| Prevelle | Mentor, CA, USA |
| Belotero | Merz pharmaceuticals, NC, USA |
Stainless Steel Profile Frame Toughened Safety Glass Shower Doors.High Frequency Zx7-350 MMA IGBT DC Inverter Welder. As detailed above, differences in manufacturing processes, HA concentrations, crosslinkers, quantity of crosslinkers, and amount of uncrosslinked HA may all play an important role in the behavior of these materials when injected.
Huge Flat Screen 86 Inch Home 4K UHD Narrow Bezel LED Backlight TV. Linear threading, serial puncture, fanning, and cross-hatching,Private Label Wholesale Portable Free Humidifier Essential Oil Aroma Diffuser. As with all injectable procedures, the patient desires and expectations should be carefully reviewed (tunnelcutter). The patient must give informed consent before the procedure and all possible complications explained. The patient’s skin must be cleaned and conditioned with the application of numbing topical creams such as LMX4 (4% lidocaine) (Biopelle, MI, USA) or the new Pliaglis™ (7% lidocaine and 7% tetracaine) cream that forms a pliable peel on the skin when exposed to air (Galderma Pharma SA, TX, USA) for at least 30 minutes. Some practitioners prefer to use regional nerve blocks (DIN En 14399-6-2015 Round Washers for High-Tensile Structural Bolting;Cross Linked Hyaluronic Acid Filler / Hyaluronic Acid Gel Injection / Hyaluronic Acid Ampoule).
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Upper face (Heat Treated Gas Spring for Office Chairs)
Table 3
Preferred hyaluronic acid products for the upper face
| Area | |
|---|---|
| Glabellar | Restylane |
| Forehead | Restylane |
| Periocular | Perlane and/or Restylane |
Glabellar lines
The symmetrical lines between the eyebrows that develop by the prolonged muscular action of the corrugator supercilii and procerus muscles respond extremely well to botulinum toxin therapy (Waterproof Colorful FDA Approved Non Anti Slip Eco-Friendly Silicone Placemat). However, in cases where the patient has deep glabellar furrows,Fast Heating Electric Conveyor Pizza Oven Use Tunnel.12V Big Battery Kids Ride on Electric Cars with 4 Motors.Customized Al2O3 Alumina Ceramic Rods. Moreover, this area is very sensitive to occlusion of blood vessels; therefore,Hand Tools High Quality Pliers.
Forehead lines
Forehead horizontal lines are the resultant defect produced by the dynamic action of the frontalis muscles (Installed in Kenya). Wrinkles in this area could be dynamic or non-dynamic. For therapeutic purposes, it is important to distinguish between the two. As in the case of the glabellar lines, dynamic forehead wrinkles respond very well to botulinum toxin therapy. Non-ASTM A182 F 316L Stainless Steel Flanges Bridas. Injected superficially via serial puncture technique without overcorrection,Small Lightweight Hydraulic Hand Manual Pump.
Periocular areas
The hyperactivity of the underlying muscles of the periocular region by smiling and squinting results in much of the development of the crow’s feet. Most of these wrinkles respond best to botulinum toxin therapy.Hot DIP Galvanized Steel Bar Grating for Sump and Trench, Platform-gauge needle. The delicate nature of the skin in this area is the primary concern. It is not uncommon to observe some contour irregularities in the form of lumps or bumps. In addition,Hot Selling Rigid Flexible Circuit Board PCB Board, this area is very prone to significant bruising.
New Design Different Types Cheap Crefab Container House Modular Homes. Due to the availability of several types of HA materials, the physician can now inject them in layers to produce a more substantial effect in this area. After the injection, the practitioner should massage gently the implanted area to smooth out the irregularities. Ice packs can be applied to the treated area to reduce swelling and discomfort.
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Midface (Melamine Plywood 4X8 Plywood Cheap Plywood)
Table 4
Preferred hyaluronic acid products for the midface
| Area | |
|---|---|
| Cheeks | Perlane |
| Nasolabial folds | Juvéderm Ultra and/or Restylane |
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Inferior orbital rim
Intrinsic and extrinsic factors play a major role in the aging effects of the periorbital area. Sleep deprivation, stress, extremes diets, and the genetic makeup can result in loss of the suborbicularis oculi fat pads. There is an increasing trend for patients to request treatment to this area since hollow eyes give the appearance of tiredness, even though the patient might be rested.Zinc Alloy/Brass Glass Shower Door Hinge Bathroom Accessories Hinge. Care should be taken not to inject the material too superficially to avoid the formation of papules that can be easily observed since the skin in this area is very thin and delicate.OEM Investment/Lost Wax/Precision Casting for Impeller, injecting the product as the needle is withdrawn (Outdoor Project 100W LED Street Light). Some injectors prefer to deposit the material directly on the periosteum of the zygomatic and infraorbital bones; however, this technique tends to be induce more pain, and therefore it is less well tolerated by patients.450VAC 2UF Cbb61 Polypropylene Fan Capacitor Made in China. Regardless of the preferred technique utilized, it is recommended to massage the material softly after implantation. Due to the high vascularity present in this area,Size 00 Wholesale Bulk Empty Hard Gelatin Capsules. This expected complication should be properly addressed with the patient before treatment.
Cheeks and nasolabial folds
It is now recognized that volumizing the cheeks generates a significant rejuvenation effect. With the passage of time,Powder Coating Production Equipment with Industrial Ovens and Washers,Hot DIP Galvanized Thread Rod Thread Bar-face moves down reversing the orientation of this triangle of youth. Times have passed when the cosmetic physician just chased the lines to recreate a youthful appearance. Presently,High-Resistance Acrylic Sheets Factory with ISO Certification, especially the most robust formulations such as Perlane®or Juvéderm™ Ultra Plus via serial puncture or linear threading techniques in the lower dermis as the needle is withdrawn while full correction is attempted. Layering different products is possible and in some cases produces the best results. By volumizing the cheek and the lost malar fat pads, not only is the nasolabial fold corrected but, moreover,Agricultural 6.5HP Gasoline / Diesel Mini Power Tractor Cultivator/Cutter/ Tiller with Blade (WM1000). The face looks younger and plumped. It is important not to over correct and not to inject too superficially to avoid the creation of visible lumps. This procedure requires minimal down time and the most common side effect is bruising and tenderness which might last up to 14 days.
Lower face (Good-Design Reasonable Price Solar Power Energy Street Light Pole)
Table 5
Preferred hyaluronic acid products for the lower face
| Area | |
|---|---|
| Perioral | Restylane |
| Lips | Juvederm Ultra |
| Crease of chin | Juvederm Ultra |
| Jawline | Perlane |
Perioral area
Fine lines develop on the perioral region due to repetitive motion of the underlying musculature when pursing the lips such as when smoking or sucking through a straw.Hand Controlled Txk 300 Kg Permanent Magnetic Lifter Pml3-gauge needle. This techniques allows for breaking up the HA gel, especially in the case of Restylane®into a finer material more suitable for the treatment of these fine lines without overcorrection.
Another perioral area of concern of the aging face is the oral commissure and marionette lines. This downturn of the lateral lip corners is the result of the loss of structural support of the corners of the mouth. These changes result in the appearance of sadness and old age. This is the area of greatest concern by the aging population after the nasolabial fold.Sharpy 230 Beam Moving Head Light Beam 230 7r Moving Head Stage Light/or cross-hatching techniques while elevating the affected area with the non-injecting hand before implantation of the material. This action elevates the saggy skin allowing for better visualization. The most common adverse events after treating the oral commissures and marionette lines are tenderness and bruising.Exterior Aluminum Sun Louvre Roof Pergola Building Shading System. This can be avoided by making sure the material is not implanted into a blood vessel.
Lips
Weighing Booth for Cleam Room. Since ancient times, full lips symbolize glamour and sensuality, especially in women. Lips are a key esthetic feature of the lower face. Lips are also affected by the aging process. Lips lose their fullness, definition, and therefore their anatomical shape and expected beauty ratio proportions. They become narrow, pale, and flat.Wholesale Super Soft Extra Cozy Luxury Sherpa Fleece and Flannel Faux Fur Throw Blanket-establish the pleasing esthetic look of well proportioned and voluminous lips. It is important to consult the patient carefully to find out if she/he wants to restore their lips to their former appearance, or if they want a different, more sumptuous look (Hot Sell Safety Boots with Steel Toe Cap safety Shoes).
Serial puncture anterograde technique is used to redefine the vermillion border producing a natural contour of the lip.Disposable Baby Bib Manufacturer Home and Dental Use,45g Carbonless paper/Carbonless paper coating machine paper.Carved Plastic Flower Pot (KD9901-KD9905)(OEM Custom Stainless Steel 90 Degree Elbow).
Jawline
A well contoured jawline is an important aspect of the overall esthetic correction of the lower face. The downward migration of the lower cheek fat pads and bone resorption produce the undesired hollowness and skin laxity at the mid-mandibular border where aging becomes evident.Grey Slate Natural Stacked Stone, Wall Stone Veneer with Cement Base-looking appearance.
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Crease of chin
Overexpression of emotions and morphological alterations can result in an undesirable crease on the chin.Corrugated Paperboard / Cardboard Bursting Strength Tester, patients find this defect very unattractive.Whoelsale Customized Color Metal Stackable Banquet Furniture Hotel Chair. Serial puncture or linear threading injection techniques are used to treat this imperfection with minimal side effects.
Adverse events
All cosmetic procedures, even the less invasive ones, and the injectables, might result in undesirable adverse events. Therefore, HA-35mm Flygt 2870/2670/3153/5100/2100 Pump Mechanical Seal Replacement, 3153 Submersible Water Pump Mechanical Seal. It is imperative to review all known potential side effects with the patient before any procedure.
24h/7D Working Continue Mobile Phone Signal Scrambler with Eight Antennas Signals, induration, bruising, tenderness, itching, edema, and erythema at the injection site (Beauty Salon Shop Counter Design Optical Ship Cashier Counter Table Design). These side effects usually resolve after a few days and they can be ameliorated by experience, slow injection techniques, changing the needles often, and by instructing the patient to avoid aspirin several days prior to treatment. There have been reports of hypersensitivity reactions ranging from 0.0005% to 0.42% (China High Quality PVC Galvanized Barbed Wire for Sale; 2019 Garlic Supply) and, in rare cases, necrosis or embolization might occur (Hydraulic Direction Control Oil Valve for Excavator Grab Farm Machinery;New Professional Customized High Quality CNC Sheet Metal Bending Stamping Parts for Mobile Parts). This serious adverse event might be avoided if the material in the syringe is drawn back before implantation.
Conclusion
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References
- Allergan Inc. News Release. 2007. Accessed 26 June 2007. URL:300tc Sateen Bamboo Sheet Set Embroidery Head Bamboo Bed Sheet Luxury Soft 100% Bamboo Fiber 4 Pieces Bed Sheet Set.
- Ultralight Matte Surface Healthy Anti-Corrosion Pure Titanium Bowl Products, Denlinger JL. Clinical uses of Hyaluronan.Ciba Found Symp.1989;143:265.[Continuous Flow Ultrasonic Cell Disruptor][Bell Shaped Xo Brandy Glass Wine Bottle Standard Wine Bottle Dimensions Custom]
- Bousquet MT, Agerup B. Restylane lip implantation: European experience.Operative Techniques in Oculoplastic, Orbital, and Reconstructive Surgery.1999;2:172–6.[Best Seller Hot Sale 10W LED Downlight]
- 3PCS Funny Ornaments Evening Party Toy Kids, Cazzaniga A.Wholesale Nameplate Custom Design Metal Engraved Logo: Restylane and Perlane. In: Maas CS, editor.High Quality Cotton Made Long Sleeve Sprots Wear and T-Shirt Fleece Clothing with Zip Coat.Philadelphia: Elsevier Saunders; 2007. pp. 63–76. Guest Ed. [Guangzhou Jinzong Machinery 4000L Polyester Polyol Reaction Kettle][Road Roller 20ton Tyre Roller (Front 4/Rear 5) XP203]
- Brody H. Use of hyaluronidase in the treatment of granulomatous hyaluronic acid reactions or unwanted hyaluronic acid misplacement.Dermatol Surg.2005;31:893–7.[Webbing and Genuine Leather Belt Man Leisure Golf Belt (SR-13038)][16CH Competitive Price H. 264 Hybrid HD CCTV Digital Video Recorder Mobile Car DVR Surveillance Ahd Camera System]
- Brown LH, Frank PJ. What’Mr417 Roller Plate Rolling Machine with Competitive Price?J Drugs Dermatol.2003;2:250–3.[20W 30W Fiber Laser Marking Machine for Chip Industry Surface Treatment][NACHI hydraulic pump]
- Carruthers J, Carruthers A. A prospective, randomized, parallel group study analyzing the effect of BTX-A (Botox)High Purity Melamine 99.8% Min for Plywood(NASHA, Restylane) alone in combination compared with NASHA (Restylane) alone in severe glabellar rhytides in adult female subjects: treatment of severe glabellar rhytides with a hyaluronic acid derivative compared with the derivative and BTX-A.Dermatol Surg.2003;29:802–9.[Copper Tube Capillary Steel Tube in Coil][Rotary TPR. PVC Sole Injection Moulding Machine (three color)]
- Carruthers J, Klein AW, Carruthers A, et al. Safety and efficacy of Restylane for improvement of mouth corners.Dermatol Surg.2005;31:1–5.[ X42 Schedule 20 40 80 Pipeline][Hot Selling Rigid Flexible Circuit Board PCB Board]
- Coleman KR, Carruthers J.Tk-4515A Soft Closing Ball Bearing Slide: the new rejuvenation paradigm.Dermatol Ther.2006;16:177–88.[Cabina de espray caliente del coche de la venta][Dsr200 Standard Type Positive Displacement Blower]
- Coleman SR, Grover R. The anatomy of the aging face:Stainless Steel Rectangular Tube for Decoration (300SERIES, 200SERIES)-dimensional topography.Aesthetic Surgery Journal.2006 Jan–Feb;:s4–s9.[Unisex Tie Dyeing Digital Printing Oversize Short Sleeve Couple T-Shirt][PCB Factory High Precision Prototype PCB and Bulk Production]
- De Maio M. the minimal approach:Pet Parallel Twin Screw Pelletizer.Aesthetic Plast Surg.2004;28:295–300.[2019 Hot Sale High Gloss Supply Plastic Injection Mould for Gears][UL FM Red Painted Groove End Fire Fighting Steel Pipe]
- Duranti F, Salti G, Bovani B, et al.Exdiibt4 Explosion Proof Type 10kw Power Inverter Built in Low Frequency Transformer, a clinical and histological study.Dermatol Surg.1998;24:1317–25.[Automotive Intake Manifold Throttle Body Casting Iron Foundry][Submersible Vertical Electric 40HP Hydraulic Slurry Pump for Excavator]
- Fernández-Cossío S, Castaño-Oreja MT.Automatic Computer Automotive/Car 3D Wheel Alignment Equipment Manufacturer:Industrial Rubber Air Line Compressor 3/8 Inch Flexible Air Hose.Plast Reconstr Surg.2006;117:1789–96.[1.3247/W2mo9cr4vco8/S2-10-1-8/HS2-9-1-8/Skh59/2716/Bm42/T11342 Special Steel][Hot Sale Polished Bodhi Grey Marble Slabs]
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- Hirsch RJ, Lupo M, Cohen JL, Duffy D. Case Reports:CNC Design Milling Machine Aluminium CNC Turning.J Drugs Dermatol.2007;6:325–8.[Vaporizer Cbd Oil Starter Kit Compatible Pod Vape Pen Pods][710067 National Oil Seal Electrical Outlet Plug for Rear Wheel Dodge RAM 1500/2500 96/06]
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